Finding an identity and meeting a standard : connecting the conflicting in teacher induction

This article has the apparently contradictory aims of describing a discourse of new teachers that is at odds with the policy-derived competence-based discourse of the professional standard for teachers, but of also seeking to find some points of connection that may help start a dialogue between policy and research. The experience of new teachers is conceptualized as personal stories of identity formation with a clear emotional-relational dimension and a sense of self and intrinsic purpose in which others, especially colleagues and children, are central - themes not visible in the standard. The empirical context is that of new teachers in Scotland but the argument is supported through a wider literature that extends beyond the traditional limits of teacher education, drawing on, for example, notions of self-identity, pure relationship and ontological security in the work of Giddens. Whether a more constructive dialogue can begin depends partly on the extent to which the formal standard can be expected to capture the complex, personal nature of the beginner's experience, and partly on the possibility of research identifying particular areas of competence, such as understanding difference, that connect in some way to the standard

Flows and uses of diaspora remittances by receiving households in Guyana

Este artigo é baseado em um caso de método misto mais amplo sobre as potencialidades e os desafios da migração e remessas para a economia da Guiana. Dados para o estudo foram coletados por meio de questionários, entrevistas, discussões em grupo, arquivos, e observações (direta e participante). Este artigo centra-se especificamente sobre os fluxos e uso das remessas monetárias e não monetárias pelas famílias guianenses que as recebem. O estudo também confirma uma dependência significativa de remessas por parte das famílias para satisfazer as suas necessidades básicas, o que confirma ainda mais a vulnerabilidade da economia da Guiana para responder a choques da economia dos países dos quais as remessas são remetidas. Apesar destes fluxos e da dependência evidente das remessa por parte das famílias que as recebem, uma política, que vise maximizar os benefícios para as famílias e a economia, ainda está para ser elaborada e implantada. Além de fazer sugestões esse respeito, indica-se futuros estudos, com a finalidade de fortalecer as políticas e a literatura existente sobre o fluxo, o uso e o impacto das remessas nas famílias guianenses

An Exploratory Study of Forces and Frictions affecting Large-Scale Model-Driven Development

In this paper, we investigate model-driven engineering, reporting on an exploratory case-study conducted at a large automotive company. The study consisted of interviews with 20 engineers and managers working in different roles. We found that, in the context of a large organization, contextual forces dominate the cognitive issues of using model-driven technology. The four forces we identified that are likely independent of the particular abstractions chosen as the basis of software development are the need for diffing in software product lines, the needs for problem-specific languages and types, the need for live modeling in exploratory activities, and the need for point-to-point traceability between artifacts. We also identified triggers of accidental complexity, which we refer to as points of friction introduced by languages and tools. Examples of the friction points identified are insufficient support for model diffing, point-to-point traceability, and model changes at runtime.Comment: To appear in proceedings of MODELS 2012, LNCS Springe

Continuum-electron interferometry for enhancement of photoelectron circular dichroism and measurement of bound, free, and mixed contributions to chiral response

We develop photoelectron interferometry based on laser-assisted extreme ultraviolet ionization for flexible and robust control of photoelectron circular dichroism in randomly oriented chiral molecules. A comb of XUV photons ionizes a sample of chiral molecules in the presence of a time-delayed infrared or visible laser pulse promoting interferences between components of the XUV-ionized photoelectron wave packet. In striking contrast to multicolor phase control schemes relying on pulse shaping techniques, the magnitude of the resulting chiral signal is here controlled by the time delay between the XUV and laser pulses. Furthermore, we show that the relative polarization configurations of the XUV and IR fields allows for disentangling the contributions of bound and continuum states to the chiral response. Our proposal provides a simple, robust and versatile tool for the control of photoelectron circular dichroism and experimentally feasible protocol for probing the individual contributions of bound and continuum states to the PECD in a time-resolved manner

A panchromatic view of PKS 0558-504: an ideal laboratory to study the disk-jet link

PKS 0558-504 is the brightest radio-loud Narrow-Line Seyfert 1 galaxy at X-ray energies. Here we present results from the radio, optical, UV, and X-ray bands obtained with Swift, XMM, and ATCA during a 10-day monitoring campaign in September 2008. The simultaneous coverage at several wavelengths makes it possible to investigate in detail the broadband spectral energy distribution (SED) and the energetic of this source. The main results can be summarized as follows. The ATCA reveals the presence of an extended radio emission in PKS 0558-504 with two lobe-like structures at ~7" from the bright central source. The extended radio structure and the low value of the radio-loudness similar to radio-quiet Seyfert galaxies coupled with constraints from higher energy bands argue against a jet-dominated emission. The study of the SED, which is dominated by a nearly constant optical-UV emission, supports the conclusion that PKS 0558-504 is accreting at super-Eddington rate. This conclusion was reached assuming M_BH=2.5e8 M_sun, which was obtained with a new scaling method based on X-ray spectral variability results. A comparison between the accretion luminosity and the kinetic power associated with the jet suggests that in this source the accretion power dominates in agreement with the results obtained from Radiation-MHD simulations of Galactic black holes (GBHs) accreting at the Eddington rate. The combined findings from this panchromatic investigation strongly suggest that PKS 0558-504 is a large-scale analog of GBHs in their highly accreting intermediate state. Importantly, PKS 0558-504 may also be the prototype of the parent population of the very radio-loud NLS1s recently detected at gamma-ray energies.Comment: 11 pages, 5 figures, 3 tables, accepted for publication in Ap

Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity:a protocol for an adaptive recall by genotype study

BACKGROUND: Pain is a complex polygenic trait whose common genetic underpinnings are relatively ill-defined due in part to challenges in measuring pain as a phenotype. Pain sensitivity can be quantified, but this is difficult to perform at the scale required for genome wide association studies (GWAS). Existing GWAS of pain have identified surprisingly few loci involved in nociceptor function which contrasts strongly with rare monogenic pain states. This suggests a lack of resolution with current techniques. We propose an adaptive methodology within a recall-by-genotype (RbG) framework using detailed phenotyping to screen minor alleles in a candidate ‘nociceptor’ gene in an attempt to estimate their genetic contribution to pain. METHODS/DESIGN: Participants of the Avon Longitudinal Study of Parents and Children will be recalled on the basis of genotype at five common non-synonomous SNPs in the ‘nociceptor’ gene transient receptor potential ankylin 1 (TRPA1). Those homozygous for the common alleles at each of the five SNPs will represent a control group. Individuals homozygous for the minor alleles will then be recruited in a series of three sequential test groups. The outcome of a pre-planned early assessment (interim) of the current test group will determine whether to continue recruitment or switch to the next test group. Pain sensitivity will be assessed using quantitative sensory testing (QST) before and after topical application of 10% cinnamaldehyde (a TRPA1 agonist). DISCUSSION: The design of this adaptive RbG study offers efficiency in the assessment of associations between genetic variation at TRPA1 and detailed pain phenotypes. The possibility to change the test group in response to preliminary data increases the likelihood to observe smaller effect sizes relative to a conventional multi-armed design, as well as reducing futile testing of participants where an effect is unlikely to be observed. This specific adaptive RbG design aims to uncover the influence of common TRPA1 variants on pain sensation but can be applied to any hypothesis-led genotype study where costly and time intensive investigation is required and / or where there is large uncertainty around the expected effect size. Trial registration: ISRCTN, ISRCTN16294731. Retrospectively registered 25th November 2021. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-022-01156-5

Conceptualizing cultures of violence and cultural change

The historiography of violence has undergone a distinct cultural turn as attention has shifted from examining violence as a clearly defined (and countable) social problem to analysing its historically defined 'social meaning'. Nevertheless, the precise nature of the relationship between 'violence' and 'culture' is still being established. How are 'cultures of violence' formed? What impact do they have on violent behaviour? How do they change? This essay examines some of the conceptual aspects of the relationship between culture and violence. It brings together empirical research into nineteenth-century England with recent research results from other European contexts to examine three aspects of the relationship between culture and violence. These are organised under the labels 'seeing violence', 'identifying the violent' and 'changing violence'. Within a particular society, narratives regarding particular kinds of behaviour shape cultural attitudes. The notion 'violence' is thus defined in relation to physically aggressive acts as well as by being connected to other kinds of attitudes and contexts. As a result, the boundaries between physical aggression which is legitimate and that which is illegitimate (and thus 'violence') are set. Once 'violence' is defined, particular cultures form ideas about who is responsible for it: reactions to violence become associated with social arrangements such as class and gender as well as to attitudes toward the self. Finally, cultures of violence make efforts to tame or eradicate illegitimate forms of physical aggression. This process is not only connected to the development of new forms of power (e.g., new policing or punishment strategies) but also to less tangible cultural influences which aim at changing the behaviour defined as violence (in particular among the social groups identified as violent). Even if successful, this three-tiered process of seeing violence, identifying the violent and changing violence continues anew, emphasising the ways that cultures of violence develop through a continuous process of reevaluation and reinvention

Surface Brightness Profiles of Composite Images of Compact Galaxies at z~4-6 in the HUDF

The Hubble Ultra Deep Field (HUDF) contains a significant number of B, V and i'-band dropout objects, many of which were recently confirmed to be young star-forming galaxies at z~4-6. These galaxies are too faint individually to accurately measure their radial surface brightness profiles. Their average light profiles are potentially of great interest, since they may contain clues to the time since the onset of significant galaxy assembly. We separately co-add V, i' and z'-band HUDF images of sets of z~4,5 and 6 objects, pre-selected to have nearly identical compact sizes and the roundest shapes. From these stacked images, we are able to study the averaged radial structure of these objects at much higher signal-to-noise ratio than possible for an individual faint object. Here we explore the reliability and usefulness of a stacking technique of compact objects at z~4-6 in the HUDF. Our results are: (1) image stacking provides reliable and reproducible average surface brightness profiles; (2) the shape of the average surface brightness profiles show that even the faintest z~4-6 objects are resolved; and (3) if late-type galaxies dominate the population of galaxies at z~4-6, as previous HST studies have shown, then limits to dynamical age estimates for these galaxies from their profile shapes are comparable with the SED ages obtained from the broadband colors. We also present accurate measurements of the sky-background in the HUDF and its associated 1-sigma uncertainties.Comment: 10 pages, 9 figures, 2 tables, emulateapj; Accepted for publication in The Astronomical Journa

Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation

The cyclic AMP-specific phosphodiesterase PDE8 has been shown to play a pivotal role in important processes such as steroidogenesis, T cell adhesion, regulation of heart beat and chemotaxis. However, no information exists on how the activity of this enzyme is regulated. We show that under elevated cAMP conditions, PKA acts to phosphorylate PDE8A on serine 359 and this action serves to enhance the activity of the enzyme. This is the first indication that PDE8 activity can be modulated by a kinase, and we propose that this mechanism forms a feedback loop that results in the restoration of basal cAMP levels. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserve