29,901 research outputs found
The AdHOC study of older adults’ adherence to medication in 11 countries
BACKGROUND: Compared with the resources expended developing, evaluating
and making clinical decisions about prescribing medication, we know little about
what determines whether people take it. Older adults are prescribed more
medication than any other group. Poor adherence is a common reason for nonresponse
to medication.
OBJECTIVES: To investigate cross-nationally the impact of demographic,
psychiatric (including cognitive), physical health, behavioural and medication factors
on adherence to medication in older adults.
METHODS: Researchers interviewed 3881 people over 65 who receive home
care services using a structured interview at participants’ places of residence in
eleven countries. The main outcome measure was the percentage participants not
adherent to medication.
RESULTS: 12.5% (n= 456) of people reported they were not fully adherent to
medication. Non-adherence was predicted by problem drinking (OR=3.6), not having
a doctor review medication (OR=3.3), dementia (OR=1.4 for every one point
increase in impairment), good physical health (OR=1.2), resisting care (OR=2.1)
being married (OR=2.3) and living in the Czech Republic (OR=4.7) or Germany
(OR=1.4).
CONCLUSION: People, who screen positive for problem drinking and with
dementia, often undiagnosed are less likely to adhere to medication. Therefore
doctors should consider dementia and problem drinking when prescribing for older
adults. Interventions to improve adherence in older adults might be more effective if
4
targeted at these groups. It is possible that medication review enhances adherence,
by improving the patient-doctor relationship, or by emphasising the relevance of
medications
Improved +He potentials by inversion, the tensor force and validity of the double folding model
Improved potential solutions are presented for the inverse scattering problem
for +He data. The input for the inversions includes both the data of
recent phase shift analyses and phase shifts from RGM coupled-channel
calculations based on the NN Minnesota force. The combined calculations provide
a more reliable estimate of the odd-even splitting of the potentials than
previously found, suggesting a rather moderate role for this splitting in
deuteron-nucleus scattering generally. The approximate parity-independence of
the deuteron optical potentials is shown to arise from the nontrivial
interference between antisymmetrization and channel coupling to the deuteron
breakup channels. A further comparison of the empirical potentials established
here and the double folding potential derived from the M3Y effective NN force
(with the appropriate normalisation factor) reveals strong similarities. This
result supports the application of the double folding model, combined with a
small Majorana component, to the description even of such a loosely bound
projectile as the deuteron. In turn, support is given for the application of
iterative-perturbative inversion in combination with the double folding model
to study fine details of the nucleus-nucleus potential. A -He tensor
potential is also derived to reproduce correctly the negative Li quadrupole
moment and the D-state asymptotic constant.Comment: 22 pages, 12 figures, in Revte
The Importance of DNA Repair in Tumor Suppression
The transition from a normal to cancerous cell requires a number of highly
specific mutations that affect cell cycle regulation, apoptosis,
differentiation, and many other cell functions. One hallmark of cancerous
genomes is genomic instability, with mutation rates far greater than those of
normal cells. In microsatellite instability (MIN tumors), these are often
caused by damage to mismatch repair genes, allowing further mutation of the
genome and tumor progression. These mutation rates may lie near the error
catastrophe found in the quasispecies model of adaptive RNA genomes, suggesting
that further increasing mutation rates will destroy cancerous genomes. However,
recent results have demonstrated that DNA genomes exhibit an error threshold at
mutation rates far lower than their conservative counterparts. Furthermore,
while the maximum viable mutation rate in conservative systems increases
indefinitely with increasing master sequence fitness, the semiconservative
threshold plateaus at a relatively low value. This implies a paradox, wherein
inaccessible mutation rates are found in viable tumor cells. In this paper, we
address this paradox, demonstrating an isomorphism between the conservatively
replicating (RNA) quasispecies model and the semiconservative (DNA) model with
post-methylation DNA repair mechanisms impaired. Thus, as DNA repair becomes
inactivated, the maximum viable mutation rate increases smoothly to that of a
conservatively replicating system on a transformed landscape, with an upper
bound that is dependent on replication rates. We postulate that inactivation of
post-methylation repair mechanisms are fundamental to the progression of a
tumor cell and hence these mechanisms act as a method for prevention and
destruction of cancerous genomes.Comment: 7 pages, 5 figures; Approximation replaced with exact calculation;
Minor error corrected; Minor changes to model syste
Dual Response Models for the Fractional Quantum Hall Effect
It is shown that the Jain mapping between states of integer and fractional
quantum Hall systems can be described dynamically as a perturbative
renormalization of an effective Chern-Simons field theory. The effects of
mirror duality symmetries of toroidally compactified string theory on this
system are studied and it is shown that, when the gauge group is compact, the
mirror map has the same effect as the Jain map. The extrinsic ingredients of
the Jain construction appear naturally as topologically non-trivial field
configurations of the compact gauge theory giving a dynamical origin for the
Jain hierarchy of fractional quantum Hall states.Comment: 8 pages LaTe
Hall effect and conduction anisotropy in the organic conductor TMTSF2PF6
Long missing basic experiments in the normal phase of the anisotropic
electron system of TMTSF2PF6 were performed. Both the Hall effect and the
ab'-plane conduction anisotropy are directly addressing the unconventional
electrical properties of this Bechgaard salt. We found that the dramatic
reduction of the carrier density deduced from recent optical data is not
reflected in an enhanced Hall-resistance. The pressure- and temperature
dependence of the b'-direction resitivity reveal isotropic relaxation time and
do not require explanations beyond the Fermi liquid theory. Our results allow a
coherent-diffusive transition in the interchain carrier propagation, however
the possible crossover to Luttinger liquid behavior is placed to an energy
scale above room temperature.Comment: 5 pages, 5 figures, to be published in Phys. Rev. Let
Adapting robot paths for automated NDT of complex structures using ultrasonic alignment
Automated inspection systems using industrial robots have been available for several years. The IntACom robot inspection system was developed at TWI Wales and utilizes phased array ultrasonic probes to inspect complex geometries, in particular aerospace composite components. To increase inspection speed and accuracy, off-line path planning is employed to define a series of robotic movements following the surface of a component. To minimize influences of refraction at the component interface and effects of anisotropy, the ultrasonic probe must be kept perpendicular to the surface throughout the inspection. Deviations between the actual component and computer model used for path-planning result in suboptimal alignment and a subsequent reduction in the quality of the ultrasonic echo signal. In this work we demonstrate methods for using the ultrasonic echo signals to adapt a robotic path to achieve a minimal variation in the reflected surface echo. The component surface is imaged using phased array probes to calculate a sparse 3D point cloud with estimated normal directions. This is done through a preliminary alignment path covering approximately 25% of the total surface to minimize the impact on overall inspection time. The data is then compared to the expected geometry and deviations are minimized using least-squares optimization. Compared to manual alignment techniques, this method shows a reduction in surface amplitude variation of up to 32%, indicating that the robot is following the surface of the component more accurately
Nuclear magnetic resonance probes for the Kondo scenario for the 0.7 feature in semiconductor quantum point contact devices
We propose a probe based on nuclear relaxation and Knight shift measurements
for the Kondo scenario for the "0.7 feature" in semiconductor quantum point
contact (QPC) devices. We show that the presence of a bound electron in the QPC
would lead to a much higher rate of nuclear relaxation compared to nuclear
relaxation through exchange of spin with conduction electrons. Furthermore, we
show that the temperature dependence of this nuclear relaxation is very
non-monotonic as opposed to the linear-T relaxation from coupling with
conduction electrons. We present a qualitative analysis for the additional
relaxation due to nuclear spin diffusion (NSD) and study the extent to which
NSD affects the range of validity of our method. The conclusion is that nuclear
relaxation, in combination with Knight shift measurements, can be used to
verify whether the 0.7 feature is indeed due to the presence of a bound
electron in the QPC.Comment: Published version. Appears in a Special Section on the 0.7 Feature
and Interactions in One-Dimensional Systems. 16 page
Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release
© 2015 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)This study was funded by the British Heart Foundation (RG/09/002/2642 to F.M.M.-B.) and the Medical Research Council of the UK (G0901084 to F.M.M.-B.). ImageStream X was funded by the Wellcome Trust (101604/Z/13/Z). This work forms part of the research themes contributing to the translational research portfolio of Barts and the London Cardiovascular Biomedical Research Unit, which is supported and funded by the National Institute of Health Research
Convergence of the Optimized Delta Expansion for the Connected Vacuum Amplitude: Zero Dimensions
Recent proofs of the convergence of the linear delta expansion in zero and in
one dimensions have been limited to the analogue of the vacuum generating
functional in field theory. In zero dimensions it was shown that with an
appropriate, -dependent, choice of an optimizing parameter \l, which is an
important feature of the method, the sequence of approximants tends to
with an error proportional to . In the present paper we
establish the convergence of the linear delta expansion for the connected
vacuum function . We show that with the same choice of \l the
corresponding sequence tends to with an error proportional to . The rate of convergence of the latter sequence is governed by
the positions of the zeros of .Comment: 20 pages, LaTeX, Imperial/TP/92-93/5
The Importance of Satellite Quenching for the Build-Up of the Red Sequence of Present Day Galaxies
In the current paradigm, red sequence galaxies are believed to have formed as
blue disk galaxies that subsequently had their star formation quenched. Since
red-sequence galaxies typically have an early-type morphology, the transition
from the blue to the red sequence also involves a morphological transformation.
In this paper we study the impact of transformation mechanisms that operate
only on satellite galaxies, such as strangulation, ram-pressure stripping and
galaxy harassment. Using a large galaxy group catalogue constructed from the
SDSS, we compare the colors and concentrations of satellites galaxies to those
of central galaxies of the same stellar mass, adopting the hypothesis that the
latter are the progenitors of the former. On average, satellites are redder and
more concentrated than central galaxies of the same stellar mass.
Central-satellite pairs that are matched in both stellar mass and color,
however, show no average concentration difference, indicating that the
transformation mechanisms affect color more than morphology. The color and
concentration differences of matched central-satellite pairs are completely
independent of the halo mass of the satellite galaxy, indicating that
satellite-specific transformation mechanisms are equally efficient in haloes of
all masses. This strongly favors strangulation as the main quenching mechanism
for satellite galaxies. Finally, we determine the relative importance of
satellite quenching for the build-up of the red sequence. We find that roughly
70 percent of red sequence satellite galaxies with a stellar mass of 10^9 Msun
had their star formation quenched as satellites. This drops rapidly to zero
with increasing stellar mass, indicating that a significant fraction of red
satellites were already quenched before they became a satellite.Comment: 14 pages, 10 figures. Submitted for publication in MNRA
- …