Evaluation préclinique d’inhibiteurs de TYK2 pour la protection des cellules beta du pancréas dans le diabète de type 1

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Checks and Balances-The Limits of Beta Cell Endurance to ER Stress.

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Stearoyl-coenzyme A desaturase regulation by PI3-kinase is essential for human fibroblast response to PDGF

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Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.

Type 1 diabetes (T1D) is an autoimmune disease characterized by the progressive destruction of pancreatic beta cells. Interferon-α (IFNα), an antiviral cytokine, is expressed in the pancreatic islets in early T1D, which may be secondary to viral infections. However, not all patients harboring a type I IFN signature present signals of viral infection, suggesting that this response might be initiated by other "danger signals". Accumulation of mitochondrial double-stranded RNA (mtdsRNA; a danger signal), secondary to silencing of members of the mitochondrial degradosome, PNPT1 and SUV3, has been described to activate the innate immune response.info:eu-repo/semantics/publishe

Different exercise training protocols protect human pancreatic beta cells against endoplasmic reticulum stress-induced apoptosis

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Pre-clinical evaluation of TYK2 inhibitors for beta cell protection in type 1 diabetes

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HBP1 is a new target of FOXO down-regulated by growth factor signaling

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HBP1: a new regulator of cell proliferation downstream of AKT and FOXO

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Interferon-alpha mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes.

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Différents protocoles d'entraînement physique protègent les cellules bêta pancréatiques humaines contre l'apoptose induite par le stress du réticulum endoplasmique

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