Acquired ptosis associated with oculomotor and contralateral facial nerve synkinesis: the first reported case

Evidence of oculomotor nerve (ON) synkinesis is a common occurrence following both acquired and congenital III nerve palsy. It is generally accepted that aberrant regeneration is the likely aetiology of synkinesis in acquired III nerve palsy, following intracranial aneurysm, trauma, compressive neoplasms, cavernous sinus thrombosis and basilar meningitis

Fat Tissue’s Graft in Osteoarthritis Treatment: Indications, Preparations, and Results

Osteoarthritis (OA) represents one of the most common causes of joint pain and disability with related changes in bone morphology. In last years, this pathology is steadily increasing due to the continuous increase in the average life expectancy and the rate of active population. In recent years, there have been many conservative treatments for symptomatic gonarthrosis in order to reduce pain and delay or avoid the implantation of a knee prosthesis. The most studied and used was infiltrating treatment. Our group has been paying attention to regenerative medicine for many years, focusing on the characteristics of adipose tissue and the presence of multipotent mesenchymal cells, particularly in the vascular stromal area. Mesenchymal stem cells (MSCs) of adipose tissue can commit toward the chondrogenic, osteogenic, adipogenic, myogenic, and neurogenic lineages. Our group has continued the studies in this field by submitting this to treatment patients with grade II–III arthrosis according to the scale of Kellgren-Lawrence or patients with IV degree of such scale inoperable for internal reasons. To date, with a 4-year follow-up, our results are satisfactory in terms of pain reduction, improvement in joint function, and recovery of daily and sports activities

An automated procedure for the detection of the Yarkovsky effect and results from the ESA NEO Coordination Centre

Context: The measurement of the Yarkovsky effect on near-Earth asteroids (NEAs) is common practice in orbit determination today, and the number of detections will increase with the developments of new and more accurate telescopic surveys. However, the process of finding new detections and identifying spurious ones is not yet automated, and it often relies on personal judgment. Aims: We aim to introduce a more automated procedure that can search for NEA candidates to measure the Yarkovsky effect, and that can identify spurious detections. Methods: The expected semi-major axis drift on an NEA caused by the Yarkovsky effect was computed with a Monte Carlo method on a statistical model of the physical parameters of the asteroid that relies on the most recent NEA population models and data. The expected drift was used to select candidates in which the Yarkovsky effect might be detected, according to the current knowledge of their orbit and the length of their observational arc. Then, a nongravitational acceleration along the transverse direction was estimated through orbit determination for each candidate. If the detected acceleration was statistically significant, we performed a statistical test to determine whether it was compatible with the Yarkovsky effect model. Finally, we determined the dependence on an isolated tracklet. Results: Among the known NEAs, our procedure automatically found 348 detections of the Yarkovsky effect that were accepted. The results are overall compatible with the predicted trend with the the inverse of the diameter, and the procedure appears to be efficient in identifying and rejecting spurious detections. This algorithm is now adopted by the ESA NEO Coordination Centre to periodically update the catalogue of NEAs with a measurable Yarkovsky effect, and the results are automatically posted on the web portal.Comment: Accepted for publication on A&

RUOLO DELLA MEDICINA RIGENERATIVA NEI PAZIENTI AFFETTI DA SCLERODERMIA

La sclerodermia è una malattia infiammatoria cronica del tessuto connettivo caratterizzata da fibrosi interessante la cute il sottocute, i vasi ed altri organi. L’obiettivo del nostro studio è valutare l’efficacia delle tecniche di medicina rigenerativa (lipofilling ed infiltrazione di cellule derivate dal grasso del paziente dette Adiposed-derived-stem cells) nel migliorare le sequele della malattia che spesso affliggono i pazienti sclerodermici. Ci proponiamo di ottenere un miglioramento del trofismo tissutale, di garantire una fisiologica apertura della bocca e infine di accelerare i processi di guarigione di ulcere digitali. Sono stati arruolati pazienti affetti da sclerodermia sistemica diffusa, sclerodermia localizzata morphea e sclerodermia localizzata lineare. Il prelievo del tessuto adiposo è stato effettuato tramite liposuzione. Per l’ottenimento delle ADSCs il prelievo è stato inviato ad un laboratorio dedicato. Dopo la coltura in vitro, le cellule sono state infiltrate nel paziente veicolate con acido ialuronico. Il follow-up è stato eseguito ad 1-3-6-9 mesi ed 1 anno. Già dopo 3 mesi dall’infiltrazione abbiamo ottenuto un notevole miglioramento del trofismo cutaneo, associato ad una notevole soddisfazione dei pazienti. Le tecniche di medicina rigenerativa sembrano essere una valida cura per il miglioramento dei difetti estetici e funzionali nei pazienti affetti da sclerodermia

Chapter 17. Imaging and surgical strategies for cutaneous neoplasm of scalp

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Suspected spinocellular carcinoma of the inferior eyelid resulted multiple chalazion.

Chalazion is a subacute granulomatous inflammation of the eyelid caused by retention of tarsal gland secretions1 and it's the most common inflammatory lesion of the eyelid. In cases of doubtful clinical presentation the diagnosis with a biopsy and a histopathological examination is important because it can orientate an appropriate surgical treatment. We report a case of a 64-years-old diabetic man, suspected for a spinocellular lesion of the inferior eyelid of the left eye, it resulted unexpectedly a chalazion. KEY WORDS: Chalazion, Diabetes, Eyelids, Neoplasm, Spinocellular carcinoma, Suspected lesion

Disfiguring facial hemangioma compromising labial functionality: a case report

Hemangiomas are proliferative lesions characterized by increased endothelial cell turnover. Lip hemangiomas can distort lip anatomy and are at increased risk of ulceration and/or bleeding, which lead to impaired function and disfigurement. Surgery can provide active treatment but it can be problematic because vermilion tissue is unique and not found elsewhere on the body. Since there is no similar tissue that can easily be used for reconstructing missing vermilion, its preservation is essential for a satisfactory cosmetic result. We present the case of a 74 year old woman suffering from a large hemangioma of the mid-face and particulary with an angiomatous ulcerated lesion at the level of the lower lip. We describe clinical management and surgical treatment of this pathology

1. Fat Tissue’s Graft in Osteoarthritis Treatment: Indications, Preparations and Results. Osteoarthritis Biomarkers and Treatments

Osteoarthritis (OA) represents one of the most common causes of joint pain and disability with related changes in bone morphology. In last years, this pathology is steadily increasing due to the continuous increase in the average life expectancy and the rate of active population. In recent years, there have been many conservative treatments for symptomatic gonarthrosis in order to reduce pain and delay or avoid the implantation of a knee prosthesis. The most studied and used was infiltrating treatment. Our group has been paying attention to regenerative medicine for many years, focusing on the characteristics of adipose tissue and the presence of multipotent mesenchymal cells, particularly in the vascular stromal area. Mesenchymal stem cells (MSCs) of adipose tissue can commit toward the chondrogenic, osteogenic, adipogenic, myogenic, and neurogenic lineages. Our group has continued the studies in this field by submitting this to treatment patients with grade II–III arthrosis according to the scale of Kellgren-Lawrence or patients with IV degree of such scale inoperable for internal reasons. To date, with a 4-year follow-up, our results are satisfactory in terms of pain reduction, improvement in joint function, and recovery of daily and sports activities