Biologia reprodutiva de Rourea induta Planch. (Connaraceae), uma espécie heterostílica de cerrado do Brasil Central.

(Biologia reprodutiva de Rourea induta Planch. (Connaraceae), uma espécie heterostílica de cerrado do Brasil Central). A heterostilia é um polimorfismo floral geralmente associado a sistemas genéticos de intramorfo incompatibilidade. Nós avaliamos aspectos reprodutivos da heterostilia de uma população de Rourea induta Planch. em uma área de cerrado de Brasília, DF. Foram conduzidos estudos sobre sua biologia floral, sistema reprodutivo, produção e maturação de frutos, germinação de sementes, fenologia reprodutiva e visitantes florais. As flores são pequenas (11 mm de diâmetro), com morfologia simples e possuem dois grupos de cinco estames de comprimentos diferentes e cinco pistilos. O comprimento médio de estames e pistilos diferiu significativamente entre o morfo brevistilo e o longistilo. No entanto, não houve hercogamia recíproca completa entre os dois morfos florais. Os dois morfos são intramorfo incompatíveis, mas o morfo brevistilo é completamente auto-incompatível enquanto o longistilo é parcialmente autocompatível. Apesar das diferenças na morfologia floral e no sistema reprodutivo entre os morfos, estes apresentam igual sucesso reprodutivo em condições naturais, uma vez que a produção e a maturação de frutos por planta e a taxa de germinação das sementes não diferiram significativamente. A população de R. induta apresentou floração tipo “pulsed bang” com alta sincronia intra-individual e inter-individual de floração. Grande variedade de insetos, principalmente pequenas abelhas sociais, foi observada visitando as flores. Nossos resultados sugerem que a auto-incompatibilidade parcial, a incompatibilidade intramorfo e as diferenças nas alturas dos verticilos reprodutivos entre os dois morfos reduzem os níveis de autogamia em R. induta. Em última análise, a maior produção de frutos por polinização intermorfo, promoveu a razão isoplética na população estudada e indicou que R. induta é dependente dos polinizadores para a reprodução sexuada

Telecentric F-theta fisheye lens for space applications

A very wide angle lens with a field of view of 360°x180° - a fisheye lens - has been designed to be used in a space environment. As a case study, the lens is assumed to be mounted on a spinning probe passing through a comet’s tail. The lens, rotating with the probe passing through the comet coma, may map the entire sky as viewed from the interior tail, providing unprecedented data on the spatial distribution of plasma and dust. Considering the foreseen space applications for the lens, radiation hardened glass has been taken into account for the design. A key feature of the lens is the “angular scale” uniformity (F-theta) of the sky distribution map projected on the focal plane allowing to obtain a reliable whole sky reconstruction. Care has also been taken to obtain an almost telecentric design, in order to permit filters placed on the focal plane to work properly. A telecentric fisheye operating with a pixel-limited resolution in the waveband from 500 nm up to 770 nm and with an F-theta distortion is presented in this paper

The fisheye of the comet interceptor's EnVisS camera

Entire Visible Sky (EnVisS) camera is one of the payload proposed for the ESA selected F-Class mission Comet Interceptor. The main aim of the mission is the study of a dynamic new comet, or an interstellar object, entering the inner solar system for the first time. The Comet Interceptor mission is conceived to be composed of three spacecraft: a parent spacecraft A and two, spacecraft B1 and B2, dedicated to a close and risky fly-by. EnVisS will be mounted on spacecraft B2, which is foreseen to be spin-stabilized. The EnVisS camera is designed to capture the entire sky in some visible wavelength bands while the spacecraft pass through the comet's coma. EnVisS optical head is composed of a fisheye lens with a field of view of 180° x 40° coupled with an imaging detector equipped with both band-pass and polarimetric filters. The design of fisheye lenses requires to take into account some issues typical of very wide-angle lenses. The fundamental origin of the optical problems resides on the entrance pupil shift at large angle, where the paraxial approximation is no more valid: chief rays angles on the object side are not preserved passing through the optics preceding the aperture stop (fore-optics). This effect produces an anamorphic deformation of the image on the focal plane, i.e. the focal length is changing along the elevation angles. Tracing the rays appropriately requires some effort by the designer. It has to be considered that distortion, including anamorphism, is an aberration that does not affect the quality of a point source image, thus it can be present also in well corrected lenses. In this paper the optical design of the fisheye lens, that will be mounted on the EnVisS camera for the ESA F-class "Comet Interceptor" mission, will be presented together with the initial optical requirements and the final expected optical performances

Development and validation of a composite disease activity score for juvenile idiopathic arthritis

Objective. To develop and validate a composite disease activity score for juvenile idiopathic arthritis (JIA), the Juvenile Arthritis Disease Activity Score (JADAS). Methods. The JADAS includes 4 measures: physician global assessment of disease activity, parent/patient global assessment of well-being, active joint count, and erythrocyte sedimentation rate. These variables are part of the American College of Rheumatology (ACR) Pediatric 30 (Pedi 30), Pedi 50, and Pedi 70 criteria for improvement. Validation analyses were conducted on >4,500 patients and included assessment of construct validity, discriminant validity, and responsiveness to change. Three versions of the JADAS were tested based on 71-joint (range 0 \u2013101), 27-joint (range 0 \u201357), or 10-joint (range 0 \u2013 40) counts. Statistical performances of the JADAS were compared with those of 2 rheumatoid arthritis composite scores, the Disease Activity Score in 28 joints (DAS28) and the Clinical Disease Activity Index (CDAI). Results. The JADAS demonstrated good construct validity, yielding strong correlations with JIA activity measures not included in the score and moderate correlations with the Childhood Health Assessment Questionnaire. Correlations obtained for the 3 JADAS versions were comparable, but superior to those yielded by the DAS28 and CDAI. The area under the curve of the JADAS predicted long-term disease outcome, measured as radiographic progression over 3 years. In 2 clinical trials, the JADAS discriminated well between ACR Pedi 30, Pedi 50, and Pedi 70 response and revealed strong responsiveness to clinical change. Conclusion. The JADAS was found to be a valid instrument for assessment of disease activity in JIA and is potentially applicable in standard clinical care, observational studies, and clinical trials

Disease activity states, reasons for discontinuation and adverse events in 1038 Italian children with juvenile idiopathic arthritis treated with etanercept

The advent of biologic medications has increased considerably the potential for treatment benefit in juvenile idiopathic arthritis (JIA), with clinical remission being now achievable in a substantial proportion of patients. However, there is a need of data from the real world of clinical practice to evaluate thoroughly the efficacy and safety profile of the biologic agents currently approved