Further Development and Testing of the Combined U-Thdisequilibrium/ U-Pb and (U-Th)/He Zircon Dating Method and its Application to Quaternary Volcanic Rocks

Volcanic eruptions that are <1 Ma are significant for geological and archaeological investigations, however these eruptions can be challenging to date. Zircon double-dating (ZDD) is one of the few techniques that can be used to date young volcanic rocks, and combines the (U-Th)/He method with individual zircon crystallisation ages to yield eruption ages. This thesis presents several methodological improvements to the ZDD methodology and applies it to two case studies

MS-150-10-f02-012: Letter from Connemara, 1898

1 handwritten letter, 4 pages.Letter from [Lord] Connemara [Robert Bourke] dated Nov. 27, [1897]. Concerning the missing of a reception due to his wife being ill [Lady Gertrude Connemara]

MS-150-10-f02-010: Letter from Connemara

1 handwritten letter, 2 pages.Letter from [Lord] Connemara [Robert Bourke], dated May 23, [no year]. Inviting Arnold to dinner with Indian friend

MS-150-10-f02-011: Letter from Connemara, 1897

1 handwritten letter, 1 page.Letter from [Lord] Connemara [Robert Bourke] dated Nov. 27, [1897]. Concerning the missing of a reception due to his wife being ill [Lady Gertrude Connemara]

MS-150-10-f02-013: Letter from Connemara, n.d.

1 handwritten letter, 1 page.Letter from [Lord] Connemara [Robert Bourke], dated Dec.? 27, thanking him for his prompt attention to his reques

Network-targeted combination therapy : a new concept in cancer treatment

Toxicity is a major concern for anti-neoplastic drugs, with much of the existing pharmacopoeia being characterized by a very narrow therapeutic index. 'Network-targeted' combination therapy is a promising new concept in cancer therapy, whereby therapeutic index might be improved by targeting multiple nodes in a cell's signaling network, rather than a single node. Here, we examine the potential of this novel approach, illustrating how therapeutic benefit could be achieved with smaller doses of the necessary agents