Aldosterone excretion from infancy to adult life

A method is described for collecting and processing urine from infants for analysis of its content of steroids. Recovery experiments indicate an accuracy of 70 to 90 per cent. A range of normal values for urinary excretion of aldosterone by infants, children and young adults is recorded.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32111/1/0000161.pd

METABOLIC STUDIES OF CHLORPROPAMIDE IN NORMAL MEN AND IN DIABETIC SUBJECTS

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72472/1/j.1749-6632.1959.tb39585.x.pd

Some characteristics of the insulin augmentation phenomenon

A serum protein fraction possessing the capacity to augment insulin action on adipose tissue in vitro has been isolated and studied. Factors responsible for augmentation have been found to be nondialyzable and susceptible to destruction by ethanol, alkali and heat. The augmentation phenomenon is probably dependent upon the presence of a protein moiety.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31985/1/0000027.pd

Further studies on insulin augmentation capacities of various serum proteins

The ability of human serum protein to augment the action of crystalline insulin on the epididymal fat pad has been further evaluated. Serum proteins were fractionated by elution from DEAE cellulose and the capacity of individual fractions to augment insulin action determined. The property was found to be present in all fractions, but concentrated to a slightly greater extent in the fastermoving gamma globulins and beta globulins. The augmentation effect has again been found to be deficient in diabetes mellitus.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32000/1/0000042.pd

The effect of frozen storage on serum insulin-like activity

Storage of serum at -20 C. is associated with an increase of its insulin-like activity in as short a period as 3 weeks. Separated serum proteins also show an increase under similar conditions. This is of practical importance for workers who make such measurements. The possibility that these observations result from alterations in a serum insulin moiety is discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33483/1/0000888.pd

Studies on the natural history of asymptomatic diabetes in young people

Forty-five young patients with chemical diabetes have been followed for 1-16 yr. Among 21 of them aged 9-17 yr, 4 have developed insulin-dependent diabetes mellitus. None of the 24 aged 18-25 yr have decompensated. Delayed and subnormal insulin response to oral glucose was noted in those with chemical diabetes compared to normals, except for one nonobese patient who had hyperinsulinemia. Considerable fluctuation in glucose and/or insulin responses and their relationship was noted in repeated testing. These observations emphasize that validation of diagnostic criteria for glucose tolerance test interpretation need not depend on a high rate of progression to more severe hyperglycemia, and that the slow progression of latent diabetes permits consideration of prophylactic measures.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33960/1/0000230.pd

METABOLIC EFFECTS OF SULFONYLUREAS IN NORMAL MEN and IN VARIOUS TYPES OF DIABETIC PATIENTS

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73037/1/j.1749-6632.1957.tb54592.x.pd

INTERMITTENT ALDOSTERONISM IN PERIODIC PARALYSIS : DEPENDENCE OF ATTACKS ON RETENTION OF SODIUM, AND FAILURE TO INDUCE ATTACKS BY RESTRICTION OF DIETARY SODIUM

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32503/1/0000591.pd

CHARACTERISTICS OF THE INCREASED ADRENOCORTICAL FUNCTION OBSERVED IN MANY OBESE PATIENTS *

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75360/1/j.1749-6632.1965.tb34805.x.pd