Enhanced Vision Flight Deck Technology for Commercial Aircraft Low-Visibility Surface Operations

NASA Langley Research Center and the FAA collaborated in an effort to evaluate the effect of Enhanced Vision (EV) technology display in a commercial flight deck during low visibility surface operations. Surface operations were simulated at the Memphis, TN (FAA identifier: KMEM) air field during nighttime with 500 Runway Visual Range (RVR) in a high-fidelity, full-motion simulator. Ten commercial airline flight crews evaluated the efficacy of various EV display locations and parallax and mini cation effects. The research paper discusses qualitative and quantitative results of the simulation experiment, including the effect of EV display placement on visual attention, as measured by the use of non-obtrusive oculometry and pilot mental workload. The results demonstrated the potential of EV technology to enhance situation awareness which is dependent on the ease of access and location of the displays. Implications and future directions are discussed

Natural History of Tuberculosis: Duration and Fatality of Untreated Pulmonary Tuberculosis in HIV Negative Patients: A Systematic Review

Background The prognosis, specifically the case fatality and duration, of untreated tuberculosis is important as many patients are not correctly diagnosed and therefore receive inadequate or no treatment. Furthermore, duration and case fatality of tuberculosis are key parameters in interpreting epidemiological data. Methodology and Principal Findings To estimate the duration and case fatality of untreated pulmonary tuberculosis in HIV negative patients we reviewed studies from the pre-chemotherapy era. Untreated smear-positive tuberculosis among HIV negative individuals has a 10-year case fatality variously reported between 53% and 86%, with a weighted mean of 70%. Ten-year case fatality of culture-positive smear-negative tuberculosis was nowhere reported directly but can be indirectly estimated to be approximately 20%. The duration of tuberculosis from onset to cure or death is approximately 3 years and appears to be similar for smear-positive and smear-negative tuberculosis. Conclusions Current models of untreated tuberculosis that assume a total duration of 2 years until self-cure or death underestimate the duration of disease by about one year, but their case fatality estimates of 70% for smear-positive and 20% for culture-positive smear-negative tuberculosis appear to be satisfactory

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Crew State Monitoring and Line-Oriented Flight Training for Attention Management

Loss of control –inflight (LOC-I) has historically represented the largest category of commercial aviation fatal accidents. A review of worldwide transport airplane accidents (2001-2010) indicated that loss of airplane state awareness (ASA) was responsible for the majority of the LOC-I fatality rate. The Commercial Aviation Safety Team (CAST) ASA study identified12 major themes that were indicated across the ASA accident and incident events. One of the themes was crew distractionorineffective attention management, which was found to be involved in all 18 events including flight crew channelized attention, startle/surprise, diverted attention, and/or confirmation bias. Safety Enhancement(SE)-211, “Training for Attention Management” was formed to conduct research to develop and assess commercial airline training methods and realistic scenarios that can address these attention-related human performance limitations. This paper describes NASA SE-211 research for new design approaches and validation of line-oriented flight training (LOFT)

Mangos / Rosemary Clooney, chant ; Avec Franck Comstock et son orchestre. Pet me poppa / Rosemary Clooney, chant ; Avec Ray Conniff et son orchestre. Who dot mon, mom / Rosemary Clooney, chant. Hello young lovers : du film "Le roi et moi" / Rosemary Clooney, chant ; Avec Wally Stott et son orchestre

Comprend : Mangos / Rosemary Clooney, chant ; Avec Franck Comstock et son orchestre ; Pet me poppa / Rosemary Clooney, chant ; Avec Ray Conniff et son orchestre ; Who dot mon, mom / Rosemary Clooney, chant ; Hello young lovers / Rosemary Clooney, chant ; Avec Wally Stott et son orchestreBnF-Partenariats, Collection sonore - BelieveContient une table des matière

Insights into the molecular mechanisms underlying diversified wing venation among insects

Insect wings are great resources for studying morphological diversities in nature as well as in fossil records. Among them, variation in wing venation is one of the most characteristic features of insect species. Venation is therefore, undeniably a key factor of species-specific functional traits of the wings; however, the mechanism underlying wing vein formation among insects largely remains unexplored. Our knowledge of the genetic basis of wing development is solely restricted to Drosophila melanogaster. A critical step in wing vein development in Drosophila is the activation of the decapentaplegic (Dpp)/bone morphogenetic protein (BMP) signalling pathway during pupal stages. A key mechanism is the directional transport of Dpp from the longitudinal veins into the posterior crossvein by BMP-binding proteins, resulting in redistribution of Dpp that reflects wing vein patterns. Recent works on the sawfly Athalia rosae, of the order Hymenoptera, also suggested that the Dpp transport system is required to specify fore- and hindwing vein patterns. Given that Dpp redistribution via transport is likely to be a key mechanism for establishing wing vein patterns, this raises the interesting possibility that distinct wing vein patterns are generated, based on where Dpp is transported. Experimental evidence in Drosophila suggests that the direction of Dpp transport is regulated by prepatterned positional information. These observations lead to the postulation that Dpp generates diversified insect wing vein patterns through species-specific positional information of its directional transport. Extension of these observations in some winged insects will provide further insights into the mechanisms underlying diversified wing venation among insects