Elastic stress concentration at radial crossholes in pressurised thick cylinders

Results of a parametric finite element analysis investigation of stress concentration at radial crossholes in pressurized cylinders are presented in numerical and graphical form. The analysis shows that the location of maximum stress does not generally occur at the junction between the bores, as is commonly supposed, but at some small distance up the crosshole from the junction. Maximum stress concentration factors (SCFs) are defined on the basis of the maximum principal stress, von Mises equivalent stress, and stress intensity. Three-dimensional plots of the SCF against the cylinder radius ratio b/a and the crosshole-to-main-bore-radius ratio c/a are presented. The SCFs were found to vary across the range of geometries considered with local minima identified within the parameter range in most cases. The results therefore allow designers to select optimum b/a and c/a ratios to minimize stress concentration in real problems

High cycle fatigue analysis in the presence of autofrettage compressive residual stress

An experimental and numerical investigation of the effect of residual compressive stress on the high cycle fatigue life of notched low carbon steel test specimens is presented. Experimentally determined cyclic stress strain curves for S355 low carbon steel are utilized in a Finite Element Analysis plasticity modelling framework incorporating a new cyclic plasticity material model representative of cyclic hardening and softening, cyclic mean stress relaxation and ratcheting behaviors. Fatigue test results are presented for standard tensile fatigue test specimens and novel double notch specimens. Double notch specimens are tested with and without compressive residual stress prior-induced through tensile overload. It is shown that cyclic plasticity phenomena have a significant influence on the induced residual stress distribution and also on material behavior when fatigue tested in the high cycle regime. It is observed that higher initial compressive residual stresses magnitude does not necessarily lead to a longer fatigue life. Finite Element Analysis using the new cyclic plasticity material model shows this behavior is due to combined residual stress redistribution under fatigue test cyclic loading and cyclic hardening effects. A fatigue life methodology based on the stress-life approach augmented by a critical distance method is proposed and shown to give good agreement with experimental results for test specimens with no induced residual stress. The results obtained for specimens with induced residual stress are more conservative but the degree of conservatism is significantly lower than that in the conventional stress life approach. The proposed methodology is therefore suitable for analysis and design assessment of components with pre-service induced compressive residual stress, such as autofrettaged pressure components

LEADER 5: prevalence and cardiometabolic impact of obesity in cardiovascular high-risk patients with type 2 diabetes mellitus: baseline global data from the LEADER trial

Background: Epidemiological data on obesity are needed, particularly in patients with type 2 diabetes mellitus (T2DM) and high cardiovascular (CV) risk. We used the baseline data of liraglutide effect and action in diabetes: evaluation of CV outcome results—A long term Evaluation (LEADER) (a clinical trial to assess the CV safety of liraglutide) to investigate: (i) prevalence of overweight and obesity; (ii) relationship of the major cardiometabolic risk factors with anthropometric measures of adiposity [body mass index (BMI) and waist circumference (WC)]; and (iii) cardiometabolic treatment intensity in relation to BMI and WC. Methods: LEADER enrolled two distinct populations of high-risk patients with T2DM in 32 countries: (1) aged ≥50 years with prior CV disease; (2) aged ≥60 years with one or more CV risk factors. Associations of metabolic variables, demographic variables and treatment intensity with anthropometric measurements (BMI and WC) were explored using regression models (ClinicalTrials.gov identifier: NCT01179048). Results: Mean BMI was 32.5 ± 6.3 kg/m2 and only 9.1 % had BMI <25 kg/m2. The prevalence of healthy WC was also extremely low (6.4 % according to International Joint Interim Statement for the Harmonization of the Metabolic Syndrome criteria). Obesity was associated with being younger, female, previous smoker, Caucasian, American, with shorter diabetes duration, uncontrolled blood pressure (BP), antihypertensive agents, insulin plus oral antihyperglycaemic treatment, higher levels of triglycerides and lower levels of high-density lipoprotein cholesterol. Conclusions: Overweight and obesity are prevalent in high CV risk patients with T2DM. BMI and WC are related to the major cardiometabolic risk factors. Furthermore, treatment intensity, such as insulin, statins or oral antihypertensive drugs, is higher in those who are overweight or obese; while BP and lipid control in these patients are remarkably suboptimal. LEADER confers a unique opportunity to explore the longitudinal effect of weight on CV risk factors and hard endpoints

Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes

BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to -0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P = 0.98). There were no significant between-group differences in rates of acute pancreatitis (P = 0.07) or pancreatic cancer (P = 0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events

Use of thermography to calibrate fusion welding procedures in virtual fabrication applications

The application of infrared thermography to the measurement of transient temperature fields generated by fusion welding of ship structures is described. The purpose is to capture real data from practical welding situations, which can then be used as input to computational simulation of welding manufacturing operations (virtual fabrication). Workpiece distortion due to thermal mismatch strains constitutes a major technological and economic problem in welding fabrication, and there is worldwide research interest in simulation techniques that facilitate off-line investigation of methods to reduce distortion in real applications. The effectiveness of such methods depends critically on the thermal input stage, where the complex effects of variable arc energy transfer, non-linear material properties, and workpiece / fixture heat-sink variables are present in a practical case. Thermography provides a unique method to measure such parameters on a whole-field basis. The paper presents measurement comparisons made on large welded plate structural components between whole-field thermographic data, thermocouple data, finite-element thermal analysis, and analytical approaches. The paper also addresses relevant thermal imagery problems in this context, such as emissivity calibration and compensation methods for lens distortion. Thermography is shown to be an ideal way to identify the outcomes of practical features such as thermal discontinuities in the workpiece and the effects of weld preparation and process variables on the thermal transfer efficiency of the welding process electrical energy.peer-reviewe

Finite element analysis of out-of-plane distortion in plates due to double-sided fillet-welded attachments

Paper examining the finite element analysis of out-of-plane distortion in plates due to double-sided fillet-welded attachments. Focuses on the industrial scale fillet welding of a single stiffener