3 research outputs found
Interactions of morphine and isoflurane in horses
- Author
- Amadon RS
- Combie J
- Combie J
- Combie JD
- Di Fazio CA
- Doherty TJ
- Eger EI II
- Eisele JH
- Eugene P. Steffey
- J. Desmond Baggot
- John H. Eisele
- Kalpravidh M
- Kamerling S
- Kamerling SG
- Lake CL
- Matthews NS
- Muir WW
- Muir WW III
- Murphy MR
- Pascoe PJ
- Pascoe PJ
- Saidman LJ
- Steffey EP
- Steffey EP
- Steffey EP
- Steffey EP
- Steffey EP
- Steffey EP
- Steffey EP
- Tobin T
- Tobin T
- Tobin T.
- Whitehair KJ
- Publication venue
- 'American Veterinary Medical Association (AVMA)'
- Publication date
- Field of study
Pharmacokinetic/pharmacodynamic integration in drug development and dosage-regimen optimization for veterinary medicine
- Author
- A Källen
- A Sharma
- A Yacobi
- AS Nies
- BG Reigner
- BL Blagburn
- CC Peck
- CC Peck
- CE Hop
- CJ VanBoxtel
- DB Campbell
- DE Mager
- DG Bennett
- DR Stanski
- DW Knapp
- E Fuseau
- G Levy
- G Levy
- GL Qiao
- H Derendorf
- H Derendorf
- H Mattie
- J Dingemanse
- J Zhi
- JD Baggot
- JD Combie
- JD Unadkat
- JE Riviere
- JJ MacKichan
- JJ Reilly
- JV Gobburu
- JW Black
- KA Arrington
- KM Rassnick
- L Aarons
- LB Sheiner
- LB Sheiner
- M Danhof
- M Hammarlund-Udenaes
- M Rowland
- M Sawyer
- MA Botrel
- MC Allen
- MD Barnhart
- MF Landoni
- MF Landoni
- MF Landoni
- MF Landoni
- MN Martinez
- MO Karlsson
- NH Holford
- NH Holford
- NHG Holford
- NHG Holford
- NL Dayneka
- P Lees
- P Rolan
- Pierre-Louis Toutain
- PL Toutain
- PL Toutain
- PL Toutain
- PL Toutain
- PL Toutain
- QA McKellar
- R Temple
- RC Schoemaker
- RL Page
- SL Shafer
- T Kenakin
- T Martin-Jimenez
- TG Filloon
- TP Kenakin
- WA Colburn
- WJ Jusko
- WJ Jusko
- Publication venue
- Springer-Verlag
- Publication date
- Field of study
Pharmacokinetic (PK)/pharmacodynamic (PD) modeling is a scientific tool to help developers select a rational dosage regimen for confirmatory clinical testing. This article describes some of the limitations associated with traditional dose-titration designs (parallel and crossover designs) for determining an appropriate dosage regimen. It also explains how a PK/PD model integrates the PK model (describing the relationship between dose, systemic drug concentrations, and time) with the PD model (describing the relationship between systemic drug concentration and the effect vs time profile) and a statistical model (particularly, the intra- and interindividual variability of PK and/or PD origin). Of equal importance is the utility of these models for promoting rational drug selection on the basis of effectiveness and selectivity. PK/PD modeling can be executed using various approaches, such as direct versus indirect response models and parametric versus nonparametric models. PK/PD concepts can be applied to individual dose optimization. Examples of the application of PK/PD approaches in veterinary drug development are provided, with particular emphasis given to nonsteroidal anti-inflammatory drugs. The limits of PK/PD approaches include the development of appropriate models, the validity of surrogate endpoints, and the acceptance of these models in a regulatory environment
Organolead Compounds
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- T Ishii
- T Katou
- T Leipert
- T Li
- T Li
- T Matsui
- T Midgley
- T Midgley
- T Midgley Jr
- T Mori
- T Myvanishi
- T Niculescu
- T Nielsen
- T Nielsen
- T Nielsen
- T Nielsen
- T Nishishita
- T Okada
- T Schroeder
- T Schroeder
- T SmI
- T Tsuruta
- T Wartik
- T Wilkowa
- T-M Li
- T.H. Pearson
- TA Boyd
- TA Boyd
- TAK Al-Allaf
- TAK Al-Allaf
- TCS Ruo
- TG Pearson
- TG Pearson
- TG Pearson
- TG Pearson
- TH Coffield
- THM Manasev
- TJ Chow
- TJ Chow
- TK Hanson
- TL Cottrell
- TL Shkorbatova
- TL Shkorbatova
- TM Sugden
- TM Vickrey
- TM Vickrey
- TO Aulfield
- TP Kashcheeva
- TP Kashcheeva
- TP Korolenko
- TR Robinson
- TR Robinson
- TR Robinson
- TV Krishnan
- TV Krishnan
- U Ambanelli
- U Backes
- U Backes
- U Belluco
- U Belluco
- U Belluco
- U Belluco
- U Belluco
- U Kunze
- U Lippi
- U Prösch
- U Prösch
- V Arunachalam
- V Bade
- V Berenguer
- V Cantuti
- V Cantuti
- V Cosic
- V Emel’yanov
- V Emel’yanov
- V Foá
- V Gavrilov
- V Gavrilov
- V Genta
- V Genta
- V Genta
- V Giuliani
- V Giuliani
- V Giuliani
- V Giuliani
- V Hiev
- V Hiev
- V Hlavacek
- V Hlavacek
- V Kabaivanov
- V Kabaivanov
- V Kuppu Rao
- V Prever
- V Scarinci
- V Scarinci
- V Veljkovic
- V Vesely
- VA Green
- VA Khrustaleva
- VA Khrustaleva
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Shushunov
- VA Smith
- VC Demel Jr.
- VD Efimova
- VE Emel’yanov
- VF Mironov
- VF Mironov
- VF Mironov
- VF Traven
- VG Gurevich
- VG Kuleshov
- VG Kuleshov
- VG Kuleshov
- VG Tsvetkov
- VH Dibeler
- VH Dibeler
- VH Dibeler
- VI Faerman
- VI Tel’noi
- VI Tel’noi
- VI Tel’noi
- VI Tel’noi
- VI Tel’noi
- VK Khairullin
- VK Khairullin
- VK Khanina
- VN Ipatieff
- VN Ipatieff
- VN Ipatieff
- VN Ipatieff
- VN Ipat’ev
- VP Finelonov
- VP Muzychenko
- VS Azev
- VS Azev
- VS Azev
- VS Azev
- VS Azev
- VS Trievskii
- VV Bushin
- VV Bushin
- VV Bushin
- VV Bushin
- VV Bushin
- VV Korshak
- VV Korshak
- VV Korshak
- VV Korshak
- VV Ovchinnikov
- W Bai
- W Bai
- W Bai
- W Biltz
- W Bolanowska
- W Bolanowska
- W Bolanowska
- W Bolanowska
- W Bolanowska
- W Bolanowska
- W Bolanowska
- W Chlupacek
- W Cornelius
- W Dabeistein
- W Dahlig
- W Dulinski
- W Enning
- W Glatte
- W Grimme
- W Haubold
- W Haubold
- W Herz
- W Hubis
- W Jonghe De
- W Jost
- W Kabaivanov
- W Katz
- W Kern
- W Langenbeck
- W Laves
- W Linne
- W Machle
- W Meine
- W Mielenz
- W Niklowitz
- W Schlenk
- W Strohmeier
- W Strohmeier
- W Strohmeier
- W Ulrich
- W Wirth
- WA Aue
- WA Aue
- WA Aue
- WA Brown
- WA Brown
- WA Nugent
- WA Nugent
- WA Partridge
- WA Schulze
- WB Engelbrecht
- WD Good
- WD Good
- WD Good
- WD Good
- WD Good
- WD Harkins
- WD Harkins
- WE Becker
- WE Catlin
- WE Morris
- WE Morris
- WE Vaughan
- WF Anzilotti
- WF Lautsch
- WF Lautsch
- WF Lautsch
- WF Lautsch
- WF Lautsch
- WF Lautsch
- WF Machle
- WF Schmidt
- WF Schoen
- WG Agnew
- WH Charch
- WH Howell
- WH Hubner
- WH Thomas
- WH Thomas
- WH Thomas
- WH Zartman
- WI Throw
- WI Throw
- WI Zang
- WIL Throw
- WJ Mitchell
- WJ Niklowitz
- WJ Niklowitz
- WJ Niklowitz
- WJ Pitz
- WJ Settineri
- WL Richardson
- WL Richardson
- WL Richardson
- WL Richardson
- WL Richardson
- WL Richardson
- WL Richardson
- WN Ipatiew
- WN Ipatiew
- WN Ipatiew
- WR Law
- WR Ormandy
- WR Wade
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRA Jonghe De
- WRF Notten
- WS Levine
- WT Lyn
- WT Sturges
- WV Steele
- WW Parker
- WW Parker
- WW Parker
- WW Woessner
- X Liebl
- X Xiaoding
- X Xiaoding
- X Xiaoding
- Y Aleksandrov
- Y Kaneko
- Y Marumo
- Y Mayor
- Y Miah
- Y Miah
- Y Mizoi
- Y Sayato
- Y Shao
- Y Ta
- Y Ta
- Y Ta
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Tanaka
- Y Vasilenko
- Y Wakuri
- Y Yamamoto
- Y Yamamura
- Y Yamamura
- Y Yamamura
- Y Yonekawa
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Aleksandrov
- YA Alexandrov
- YA Alexandrov
- YD Semchikov
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YK Chau
- YM Zinov’ev
- YM Zinov’ev
- YS Drugov
- YV Zhigailo
- Z Aneva
- Z Drabent
- Z Drabent
- Z Drabent
- Z Florjanczyk
- Z Forycki
- Z Karny
- Z Kowalski
- Z Kozarzewska
- Z Turlakiewicz
- Z Turlakiewicz
- Z Turlakiewicz
- Z Turlakiewicz
- Z Turlakiewicz
- ZK Lynkina
- ZM Manulkin
- ZM Manulkin
- ZM Manulkin
- ZM Manulkin
- ZV Veksler
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1989
- Field of study