14 research outputs found
1990: Abilene Christian College Bible Lectures - Full Text
Get PDFLUKE: A GOSPEL FOR THE WORLD
Being the Abilene Christian University Annual Bible Lectures 1990
Published by ACU PRESS
1634 Campus Court Abilene, Texas 7960
Act now against new NHS competition regulations: an open letter to the BMA and the Academy of Medical Royal Colleges calls on them to make a joint public statement of opposition to the amended section 75 regulations.
Get PDFPrisiones e internados: una comparación de los establecimientos penales en América del Norte y América Latina
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A Tale of Two Wars: Public Opinion on the U.S. Military Interventions in Afghanistan and Iraq
No full textOptimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228
No full textMetallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-negative bacteria to all classes of β-lactam antibiotics, with the exception of monobactams, which are intrinsically stable to MBLs. However, existing first generation monobactam drugs like aztreonam have limited clinical utility against MBL-expressing strains because they are impacted by serine β-lactamases (SBLs), which are often co-expressed in clinical isolates. Here, we optimized novel monobactams for stability against SBLs, which led to the identification of LYS228 (compound 31). LYS228 is potent in the presence of all classes of β-lactamases and shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae (CRE)
