4,909 research outputs found
Facing the Beast Apart Together: Fear in Boys and Girls after Processing Information about Novel Animals Individually or in a Duo
In this experimental study, we made an attempt to examine gender-related peer influences on childhood fear. Nine- to 12-year-old boys and girls were provided with ambiguous and positive information about novel animals and then asked to provide a subjective fear rating of the animals under two conditions: fear of one animal was assessed individually by the child on its own, whereas fear of the other animal was measured after a brief discussion on fear-related issues with a same-gender peer. Results indicated that children who completed the FBQ after a discussion with a same-gender peer displayed lower fear beliefs scores than children who completed the questionnaire fully on their own. This fear-suppression effect was mainly evident in boys after hearing ambiguous information about the novel animals. The implications of these findings are briefly discussed
Photofission and Quasi-Deuteron-Nuclear State as Mixing of Bosons and Fermions
The empirical-phenomenological quasi-deuteron photofission description is
theoretically justified within the semiclassical, intermediate statistics
model. The transmutational fermion (nucleon) - boson (quasi-deuteron) potential
plays an essential role in the present context and is expressed in terms of
thermodynamical and of microscopical quantities, analogous to those commonly
used in the superfluid nuclear model.Comment: 7 pages, RevTex, to appear in Zeit. f. Phys.
Photofission of heavy nuclei at energies up to 4 GeV
Total photofission cross sections for 238U, 235U, 233U, 237Np, 232Th, and
natPb have been measured simultaneously, using tagged photons in the energy
range Egamma=0.17-3.84 GeV. This was the first experiment performed using the
Photon Tagging Facility in Hall B at Jefferson Lab. Our results show that the
photofission cross section for 238U relative to that for 237Np is about 80%,
implying the presence of important processes that compete with fission. We also
observe that the relative photofission cross sections do not depend strongly on
the incident photon energy over this entire energy range. If we assume that for
237Np the photofission probability is equal to unity, we observe a significant
shadowing effect starting below 1.5 GeV.Comment: 4 pages of RevTex, 6 postscript figures, Submitted to Phys. Rev. Let
Belga B-trees
We revisit self-adjusting external memory tree data structures, which combine
the optimal (and practical) worst-case I/O performances of B-trees, while
adapting to the online distribution of queries. Our approach is analogous to
undergoing efforts in the BST model, where Tango Trees (Demaine et al. 2007)
were shown to be -competitive with the runtime of the best
offline binary search tree on every sequence of searches. Here we formalize the
B-Tree model as a natural generalization of the BST model. We prove lower
bounds for the B-Tree model, and introduce a B-Tree model data structure, the
Belga B-tree, that executes any sequence of searches within a
factor of the best offline B-tree model algorithm, provided .
We also show how to transform any static BST into a static B-tree which is
faster by a factor; the transformation is randomized and we
show that randomization is necessary to obtain any significant speedup
Exploring passenger rail markets using new station catchment size and shape metrics
This paper presents a novel spatial market segmentation method to determine key user groups of a train station (such as gender, age and access mode), based on the size and shape of the station catchment area of each group. Two new indices–area ratio and composite ratio–are developed to quantify the importance of user groups for a train station. This method is applied to identify key user groups at seven train stations in Perth, Western Australia. The study offers a new way to explore the travel behaviour of train users and provides insights for rail transport planning and marketing
Neonatal-onset multisystem inflammatory disease responsive to interleukin-1 beta inhibition
BACKGROUND:Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation. Many patients have mutations in the cold-induced autoinflammatory syndrome 1 (CIAS1) gene, encoding cryopyrin, a protein that regulates inflammation.METHODS:We selected 18 patients with neonatal-onset multisystem inflammatory disease (12 with identifiable CIAS1 mutations) to receive anakinra, an interleukin-1-receptor antagonist (1 to 2 mg per kilogram of body weight per day subcutaneously). In 11 patients, anakinra was withdrawn at three months until a flare occurred. The primary end points included changes in scores in a daily diary of symptoms, serum levels of amyloid A and C-reactive protein, and the erythrocyte sedimentation rate from baseline to month 3 and from month 3 until a disease flare.RESULTS:All 18 patients had a rapid response to anakinra, with disappearance of rash. Diary scores improved (P<0.001) and serum amyloid A (from a median of 174 mg to 8 mg per liter), C-reactive protein (from a median of 5.29 mg to 0.34 mg per deciliter), and the erythrocyte sedimentation rate decreased at month 3 (all P<0.001), and remained low at month 6. Magnetic resonance imaging showed improvement in cochlear and leptomeningeal lesions as compared with baseline. Withdrawal of anakinra uniformly resulted in relapse within days; retreatment led to rapid improvement. There were no drug-related serious adverse events.CONCLUSIONS:Daily injections of anakinra markedly improved clinical and laboratory manifestations in patients with neonatal-onset multisystem inflammatory disease, with or without CIAS1 mutations
Serotonin tranporter methylation and response to cognitive behaviour therapy in children with anxiety disorders
Anxiety disorders that are the most commonly occurring psychiatric disorders in childhood, are associated with a range of social and educational impairments and often continue into adulthood. Cognitive behaviour therapy (CBT) is an effective treatment option for the majority of cases, although up to 35-45% of children do not achieve remission. Recent research suggests that some genetic variants may be associated with a more beneficial response to psychological therapy. Epigenetic mechanisms such as DNA methylation work at the interface between genetic and environmental influences. Furthermore, epigenetic alterations at the serotonin transporter (SERT) promoter region have been associated with environmental influences such as stressful life experiences. In this study, we measured DNA methylation upstream of SERT in 116 children with an anxiety disorder, before and after receiving CBT. Change during treatment in percentage DNA methylation was significantly different in treatment responders vs nonresponders. This effect was driven by one CpG site in particular, at which responders increased in methylation, whereas nonresponders showed a decrease in DNA methylation. This is the first study to demonstrate differences in SERT methylation change in association with response to a purely psychological therapy. These findings confirm that biological changes occur alongside changes in symptomatology following a psychological therapy such as CBT
A Participatory Health Promotion Mobile App Addressing Alcohol Use Problems (The Daybreak Program): Protocol for a Randomized Controlled Trial
BACKGROUND: At-risk patterns of alcohol use are prevalent in many countries with significant costs to individuals, families, and society. Screening and brief interventions, including with Web delivery, are effective but with limited translation into practice to date. Previous observational studies of the Hello Sunday Morning approach have found that their unique Web-based participatory health communication method has resulted in a reduction of at-risk alcohol use between baseline and 3 months. The Hello Sunday Morning blog program asks participants to publicly set a personal goal to stop drinking or reduce their consumption for a set period of time, and to record their reflections and progress on blogs and social networks. Daybreak is Hello Sunday Morning's evidence-based behavior change program, which is designed to support people looking to change their relationship with alcohol. OBJECTIVE: This study aims to systematically evaluate different versions of Hello Sunday Morning's Daybreak program (with and without coaching support) in reducing at-risk alcohol use. METHODS: We will use a between groups randomized control design. New participants enrolling in the Daybreak program will be eligible to be randomized to receive either (1) the Daybreak program, including peer support plus behavioral experiments (these encourage and guide participants in developing new skills in the areas of mindfulness, connectedness, resilience, situational strategies, and health), or (2) the Daybreak program, including the same peer support plus behavioral experiments, but with online coaching support. We will recruit 467 people per group to detect an effect size of f=0.10. To be eligible, participants must be resident in Australia, aged =18 years, score =8 on the alcohol use disorders identification test (AUDIT), and not report prior treatment for cardiovascular disease. RESULTS: The primary outcome measure will be reduction in the AUDIT-Consumption (AUDIT-C) scores. Secondary outcomes include mental health (Kessler's K-10), days out of role (Kessler), alcohol consumed (measured with a 7-day drinking diary in standard 10 g drinks), and alcohol-related harms (CORE alcohol and drug survey). We will collect data at baseline and 1, 3, and 6 months and analyze them with random effects models, given the correlated data structure. CONCLUSIONS: A randomized trial is required to provide robust evidence of the impact of the online coaching component of the Daybreak program, including over an extended period
Trapped electron coupled to superconducting devices
We propose to couple a trapped single electron to superconducting structures
located at a variable distance from the electron. The electron is captured in a
cryogenic Penning trap using electric fields and a static magnetic field in the
Tesla range. Measurements on the electron will allow investigating the
properties of the superconductor such as vortex structure, damping and
decoherence. We propose to couple a superconducting microwave resonator to the
electron in order to realize a circuit QED-like experiment, as well as to
couple superconducting Josephson junctions or superconducting quantum
interferometers (SQUIDs) to the electron. The electron may also be coupled to a
vortex which is situated in a double well potential, realized by nearby pinning
centers in the superconductor, acting as a quantum mechanical two level system
that can be controlled by a transport current tilting the double well
potential. When the vortex is trapped in the interferometer arms of a SQUID,
this would allow its detection both by the SQUID and by the electron.Comment: 13 pages, 5 figure
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