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    Is slower early growth beneficial for long-term cardiovascular health?

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    Background - Accelerated neonatal growth increases the later propensity to cardiovascular disease (CVD) in animals, whereas slower growth is thought to have a beneficial effect. To test this hypothesis in humans, we measured flow-mediated endothelium-dependent dilation (FMD) in a population subject to slower early growth and in healthy controls.Methods and Results - High-resolution vascular ultrasound was used to measure the change in brachial artery diameter in response to reactive hyperemia in adolescents age 13 to 16 years who were either part of a cohort born preterm and followed up prospectively (n = 216) or controls born at term ( n = 61). Greater weight gain or linear growth in the first 2 weeks postnatally was associated with lower FMD at adolescence ( regression coefficient, - 0.026-mm change in mean arterial diameter per 100-g increase in weight; 95% CI, - 0.040 to - 0.012 mm; P = 0.0003) independent of birthweight and potential confounding factors. Mean FMD in the half of the preterm population with the lowest rates of early growth was higher than in both the half with the greatest growth ( P = 0.001) and subjects born at term ( P = 0.03).Conclusions - FMD was 4% lower in adolescents with the highest compared with the lowest rate of weight gain in the first 2 weeks after birth, a substantial negative effect similar to that for insulin-dependent diabetes mellitus or smoking in adults. Our findings are consistent with the adverse effects of accelerated neonatal growth on long-term cardiovascular health and suggest that postnatal growth patterns could explain the previously reported association between birthweight and later CVD

    Velocity bias in a LCDM model

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    We use N-body simulations to study the velocity bias of dark matter halos, the difference in the velocity fields of dark matter and halos, in a flat low- density LCDM model. The high force, 2kpc/h, and mass, 10^9Msun/h, resolution allows dark matter halos to survive in very dense environments of groups and clusters making it possible to use halos as galaxy tracers. We find that the velocity bias pvb measured as a ratio of pairwise velocities of the halos to that of the dark matter evolves with time and depends on scale. At high redshifts (z ~5) halos move generally faster than the dark matter almost on all scales: pvb(r)~1.2, r>0.5Mpc/h. At later moments the bias decreases and gets below unity on scales less than r=5Mpc/h: pvb(r)~(0.6-0.8) at z=0. We find that the evolution of the pairwise velocity bias follows and probably is defined by the spatial antibias of the dark matter halos at small scales. One-point velocity bias b_v, defined as the ratio of the rms velocities of halos and dark matter, provides a more direct measure of the difference in velocities because it is less sensitive to the spatial bias. We analyze b_v in clusters of galaxies and find that halos are ``hotter'' than the dark matter: b_v=(1.2-1.3) for r=(0.2-0.8)r_vir, where r_vir is the virial radius. At larger radii, b_v decreases and approaches unity at r=(1-2)r_vir. We argue that dynamical friction may be responsible for this small positive velocity bias b_v>1 found in the central parts of clusters. We do not find significant difference in the velocity anisotropy of halos and the dark matter. The dark matter the velocity anisotropy can be approximated as beta(x)=0.15 +2x/(x^2+4), where x is measured in units of the virial radius.Comment: 13 pages, Latex, AASTeXv5 and natbi

    Chemical abundances in LMC stellar populations. II. The bar sample

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    This paper compares the chemical evolution of the Large Magellanic Cloud (LMC) to that of the Milky Way (MW) and investigates the relation between the bar and the inner disc of the LMC in the context of the formation of the bar. We obtained high-resolution and mid signal-to-noise ratio spectra with FLAMES/GIRAFFE at ESO/VLT and performed a detailed chemical analysis of 106 and 58 LMC field red giant stars (mostly older than 1 Gyr), located in the bar and the disc of the LMC respectively. We measured elemental abundances for O, Mg, Si, Ca, Ti, Na, Sc, V, Cr, Co, Ni, Cu, Y, Zr, Ba, La and Eu. We find that the {\alpha}-element ratios [Mg/Fe] and [O/Fe] are lower in the LMC than in the MW while the LMC has similar [Si/Fe], [Ca/Fe], and [Ti/Fe] to the MW. As for the heavy elements, [Ba,La/Eu] exhibit a strong increase with increasing metallicity starting from [Fe/H]=-0.8 dex, and the LMC has lower [Y+Zr/Ba+La] ratios than the MW. Cu is almost constant over all metallicities and about 0.5 dex lower in the LMC than in the MW. The LMC bar and inner disc exhibit differences in their [{\alpha}/Fe] (slightly larger scatter for the bar in the metallicity range [-1,-0.5]), their Eu (the bar trend is above the disc trend for [Fe/H] > -0.5 dex), their Y and Zr, their Na and their V (offset between bar and disc distributions). Our results show that the chemical history of the LMC experienced a strong contribution from type Ia supernovae as well as a strong s-process enrichment from metal-poor AGB winds. Massive stars made a smaller contribution to the chemical enrichment compared to the MW. The observed differences between the bar and the disc speak in favour of an episode of enhanced star formation a few Gyr ago, occurring in the central parts of the LMC and leading to the formation of the bar. This is in agreement with recently derived star formation histories.Comment: 22 pages, 20 figures; Accepted for publication in A&
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