Black and pink. Single lesion or double diagnosis?

Fibroepithelioma of Pinkus (FeP) is an uncommon skin lesion considered to be a rare variant of basal cell carcinoma (BCC), even though some researchers have argued for its classifica- tion as a trichoblastoma. FeP appears frequently as a solitary, flesh-colored, well-demarcated plaque, typically localized on the lumbosacral area of patients aged 40 to 60 years. It often develops in patients with a history of BCC, most commonly in wome

IL-17 and its role in inflammatory, autoimmune, and oncological skin diseases. State of art

Recent data support the theory of the involvement of IL-17 in the pathogenesis of several chronic inflammatory skin diseases (psoriasis, atopic dermatitis, acne, hidradenitis suppurativa) and autoimmune skin diseases (alopecia areata, vitiligo, bullous diseases). Even if the role of IL-17 in inflammatory and autoimmune diseases has been reported extensively, its role in tumor is still controversial. Some reports show that Th17 cells eradicate tumors, while others reveal that they promote the initiation and early growth of tumors. Herein, we review the role of IL-17 in the involvement of some common dermatologic diseases: psoriasis, atopic dermatitis, hidradenitis suppurativa, acne, vitiligo, melanoma, and nonmelanoma skin cancers

Therapeutic options for the treatment of actinic keratosis with scalp and face localization

Actinic keratosis (AK) is a common skin disease related to ultraviolet chronic exposure, that is now considered a squamous cell carcinoma in situ. Primary skin cancer prevention strategies should be recommended for high risk patients. There is a wide spectrum of treatment options available for AKs, and several variables should be taken into account regarding the best therapeutic choice for each patient. The purpose of this article is to review the current treatment strategies for AKs localized on the face and scalp, with a focus on the practical point of view that could be useful for choosing the best therapeutic option. The two main therapeutic approaches will be distinguished first: lesion-directed and field-directed. Afterwards, the treatment based on clinical type and patient comorbidity will be discusse

Eruptive blue nevi of the scalp in a patient with mayer-rokitansky-küster-hauser syndrome during isotretinoin therapy

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Face and scalp basal cell carcinoma treatment. A review of the literature

Basal cell carcinoma (BCC) is the most frequent skin cancer and is characterized by slow growth, even if it can be locally invasive and rarely metastasizes. Many different phenotypic presentations and histopathologic subtypes have been described, and the current guidelines subdivide BCCs into low-risk (nodular and superficial) and high-risk subtypes (micronodular, infiltrating, and morphoeic BCC and those with squamous differentiation). Dermoscopy allows the identification of the features associated with these different subtypes. Compared with the low-risk forms of BCC, more aggressive ones tend to undergo more frequently incomplete surgical excision and perineural invasion, so the identification of these lesions before surgery is extremely important. The gold standard of treatment is surgery, particularly for the H region of the face and infiltrative lesions, but other options are available and selected according to many variables, including body area, age, comorbidities, and clinical, dermoscopic, and histopathological features of the lesion. Moreover, the possible complications of surgical approaches, namely healing defects, failure of skin grafts, and wound infection, should be considered. In this review we discuss the management of BCC localized on the face and scalp, according to the currently available treatment options

Transitory auricular nodules. A peculiar adverse reaction in actinic keratosis field treatment

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Accounting and the 'Art of Government': Margaret of Austria in Abruzzo (1539-86)

This paper analyses the accounting, accountability and disciplinary practices triggered by the Ordinances of 1571 in the feudal State of Abruzzo, whose sovereign was Margaret of Austria, daughter of Emperor Charles V. In a scenario stimulated by the ascent of mercantilist discourse and police schemes, new 'technologies of government' were forged to optimize the State's collection of receipts and to minimize fraud, rendering public officers accountable and their activities visible and controllable 'at a distance'. Using the 'governmentality' framework, this paper analyses the Ordinances that disciplined the activities of the primary finance/accounting and police officers in Abruzzo. The paper complements and extends the previous literature by illustrating the wide array of accounting- and non-accounting-based disciplinary techniques enforced by the sovereign in order to shape, align and even seduce the behaviour of officers/functionaries working in the State apparatus, and the general population. The analysis goes beyond the existing literature by unveiling the implementation of the hitherto undisclosed disciplinary double system of gratification-punishment advocated by Foucault, that also involved the population in the 'State control of the mechanisms of discipline'. In a related vein, the accounting system applied displays representational, translational and distributive properties, along with novel incentive schemes.