An Anxiety Toolkit for Educators: A Guide for Working with Students at Risk for Generalized Anxiety Disorder

Generalized anxiety disorder (GAD) is one of the most common anxiety disorders and is characterized by excessive anxiety and worry, occurring more days than not, about several events or activities. For children and youth, anxiety disorders, including GAD, are the most frequent mental health problem experienced, which can seriously impair their ability to be successful at school and in their relationships with peers. Additionally, educators have reported having limited access to mental health supports and professional development opportunities tailored at effectively supporting students with mental health issues, such as increased anxiety. Therefore, the purpose of the current research project was to develop a handbook that provided useful and practical information, a set of educational sessions, activities, as well as strategies, and other resources aimed at assisting educators and practitioners with the means to support school-aged children at risk for GAD. With the voluntarily contributions of five educators who have experience supporting children with anxiety, along with the influence of Bandura’s (1986a) social cognitive theory, An Anxiety Toolkit for Educators: A Guide for Working with Students at Risk for Generalized Anxiety Disorder was developed. Once this handbook was complete, the same five educators used an evaluative questionnaire, which further assisted in determining the handbook’s level of effectiveness, practicality, and usefulness in educational settings. Lastly, implications of the present research for both theory and practice, as well as the current project’s limitations and suggestions for further research, were discussed

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Concurrent Session, Prescription for Success: Using ePortfolio to Job Prep Non-traditional Students

This session will describe the Prescription for Success program; a model to integrate three high impact strategies. Using ePortfolio, the program encompasses Writing across the Curriculum and Service Learning in a community college. The overall goal is to improve students\u27 information literacy, technology and writing skills in a pre-licensure associate degree program. Focused on making student learning visible, the program has developed a multilayered, multipronged approach to enhance student learning and prepare them to compete in the 21st century job market. This presentation will provide an overview of the integrative curriculum with both student and faculty workshops

Synthesis and reactivity of platinum(II) triphenylphosphino complexes with aromatic aldoximes

trans-[Pt(μ-Cl)Cl(PPh3)]2 reacted with arylaldoximes in 1,2-dichloroethane to afford [PtCl2(PPh3){N(OH)=CHAr}] (Ar = 3,4-dimethoxyphenyl, 1-naphthyl, 9-anthryl) where aldoxime ligands are N-coordinated to platinum. The obtained complexes are soluble in chlorinated solvents, where they afford equilibrium mixtures of cis,trans and/or (E),(Z) isomers. Equilibria in solution were studied by 31P-NMR spectroscopy and solid state structural data were obtained by single crystal X ray diffraction studies. The reactivity of [PtCl2(PPh3){N(OH)=CHAr}] complexes with basic aqueous solutions was studied, under liquid-liquid phase transfer catalysis conditions. The outcome of the reaction depends on the stereochemistry of the precursors: cis,(Z)-isomers promptly undergo cyclization to the corresponding dinuclear derivatives [Pt{μ-(2-N,O)}- {N(O)=CHAr}Cl(PPh3)]2, where two aldoximate ligands symmetrically bridge two metal centers

Platinum(II) Complexes Bearing Triphenylphosphine and Chelating Oximes: Antiproliferative Effect and Biological Profile in Resistant Cells

Platinum(II) complexes of the type [Pt(Cl)(PPh3){(κ2-N,O)-(1{C(R)=N(OH)-2(O)C6H4})}] with R=Me, H, (1 and 2) were synthesized and characterized. Single-crystal X-ray diffraction confirmed the proposed (SP4-3) configuration for 1. Study of the antiproliferative activity, performed on a panel of human tumor cell lines and on mesothelial cells, highlighted complex 2 as the more effective. In particular, it showed a remarkable cytotoxicity in ovarian carcinoma cells (A2780) and interestingly, a significant antiproliferative effect on cisplatin resistant cells (A2780cis). Investigation into the intracellular mechanism of action demonstrated that 2 had a lower ability to platinate DNA than did cisplatin, which was taken as reference, and a notably higher uptake in resistant cells. A significant accumulation in mitochondria, along with the ability to induce concentration-dependent mitochondrial membrane depolarization and intracellular reactive oxygen species production, allowed us to propose a mitochondrion-mediated pathway as responsible for the interesting cytotoxic profile of complex 2

Supported tris-triazole ligands for batch and continuous-flow copper-catalyzed huisgen 1,3-dipolar cycloaddition reactions

The lack of supported versions of the tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA) ligand, suitable for flow-chemistry applications at scale, prompted us to develop a new route for the immobilization of such tris-triazole chelating units on highly cross-linked polystyrene resins. With this aim, the preparation of the known TBTA-type monomer 3 was optimized to develop a high-yield synthetic sequence, devoid of chromatographic purifications at any stage. Then, bead-type (P7) and monolithic (M7) functional resins were obtained by the easy and scalable suspension-or mold-copolymerization of 3 with divinylbenzene. Both types of materials were found to possess a highly porous morphology and specific surface area in the dry state and could be charged with substantial amounts of Cu(I) or Cu(II) salts. After treatment of the latter with a proper reducing agent, the corresponding supported Cu(I) complexes were tested in the copper-catalyzed alkyne-azide cycloaddition reaction (CuAAC). The immobilized catalysts proved active at room temperature and, in batch and with catalyst loadings as low as 0.6 mol%, afforded quantitative conversions within 20 h. Independent of the alkyne structure, extended use of the supported catalyst in flow was also possible. In the reaction of benzylazide and propargyl alcohol, this allowed a total turnover number larger than 400 to be reached