Promoting Environments that Measure Outcomes: Partnerships for Change

This paper describes the development of the PrEMO© (Promoting Environments that Measure Outcomes) program. PrEMO© is an innovative model promoting evidence-based practice (EBP) while developing capacity and quality of Level II fieldwork placements. The PrEMO© program is described from initiation to completion, including development of site-specific learning objectives, the twelve week schedule and the role of faculty mentorship. Occupational therapy (OT) students, and university OT program faculty including academic fieldwork coordinators, partner with fieldwork educators at the site to implement EBP using a data-driven decision making (DDDM) process to guide the development of evidence-based practices. PrEMO© appears to be a useful strategy for building Level II fieldwork capacity and enhancing student and fieldwork educators’ knowledge and skills about EBP and outcome measurement in routine OT practice

Ecological Impacts of the 2015/16 El Niño in the Central Equatorial Pacific

The authors thank Cisco Werner (NOAA/NMFS) for proposing this special issue and encouraging our submission. We thank each of the editors, Stephanie Herring, Peter Stott, and Nikos Christidis, for helpful guidance and support throughout the submittal process. We also thank each of the anonymous external reviewers for thoughtful guidance and suggestions to improve the manuscript. REB, TO, RV, AH, and BVA are grateful for support from the NOAA Coral Reef Conservation Program. AC acknowledges support from the National Science Foundation for the following awards: OCE 1537338, OCE 1605365, and OCE 1031971. This is PMEL contribution no. 4698. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. government. The views expressed in the article are not necessarily those of the U.S. government. (NOAA Coral Reef Conservation Program; OCE 1537338 - National Science Foundation; OCE 1605365 - National Science Foundation; OCE 1031971 - National Science Foundation

Strategies for a Successful PhD Program: Words of Wisdom From the \u3cem\u3eWJNR\u3c/em\u3e Editorial Board

Nursing doctoral programs prepare students for research-focused careers within academic settings. The purpose of this Editorial Board Special Article is to provide PhD students and advisors with suggestions for making the most of their doctoral experience. Editorial Board members provide their individual insights on the skills and attributes students must acquire during the course of their doctoral education in order to succeed. The authors provide practical tips and advice on how to excel in a PhD program, including how to select an advisor and a dissertation committee, the importance of attending conferences to increase visibility and develop a network of colleagues, presenting and publishing research while still a student, and balancing work and personal life. Students who take full advantage of the opportunities available to them during the course of their doctoral programs will graduate well prepared to take on the multiple responsibilities of research, teaching, and leadership

P4‐564: Short‐Term Outcomes Of A Randomized Controlled Trial Of Amyloid Pet Results Disclosure In Mild Cognitive Impairment

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152786/1/alzjjalz201908111.pd

A novel role for the transcriptional modulator NusA in DNA repair/damage tolerance pathways in Escherichia coli

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2009.Includes bibliographical references.All organisms must contend with the consequences of DNA damage, induced by a variety of both endogenous and exogenous sources. Mechanisms of DNA repair and DNA damage tolerance are crucial for cellular survival after DNA damage. Translesion DNA synthesis (TLS) is one such mechanism of DNA damage tolerance which utilizes a specialized translesion DNA polymerase capable of catalyzing DNA synthesis on imperfect templates. There are two TLS polymerases present in Escherichia coli encoded by the dinB (Pol IV) and umuDC (Pol V) gene products. While TLS polymerases provide a variety of benefits to the cell, it is important that they are properly regulated as they have reduced fidelity on undamaged DNA compared to replicative DNA polymerases. Here I present evidence that the essential transcriptional modulator NusA associates with TLS polymerases in E. coli both physically, as noted for DinB, and genetically, with DinB and the umuDC gene products. Mutation of nusA renders cells sensitive to DNA damaging agents and produces phenotypes reminiscent of mutants with altered DNA processing. Moreover, I report that the nusAll mutation completely eliminates the formation of adaptive mutants, revealing that nusA+ function is required for cells to adapt and mutate in response to stress. Though the phenomenon of adaptive mutagenesis also requires dinB+, my data suggest that the role for nusA in adaptive mutagenesis extends beyond an interaction with DinB.(cont.) Furthermore, I report that NusA in addition to having a role in transcription elongation is also important for promoting survival after DNA damage. Phenotypes of nusA mutants are more exaggerated than those of TLS polymerase mutants. Genetic interactions of nusA+ with the nucleotide excision repair pathway suggest that nusA+ may play a role in a new class of NusA-dependent transcription coupled repair. Moreover, I have isolated RNA polymerase mutants with altered ability to survive after DNA damage, and this altered ability is absolutely dependent on nusA+ and uvrA+. The completion of translesion DNA synthesis requires both the insertion of a nucleotide opposite the adducted template base and extension from that position by several subsequent nucleotide additions. We present evidence that DinB is specialized to perform strikingly proficient extension after insertion opposite an N2-dG lesion. Our data indicate that cellular survival is coupled to completion of TLS and regulation of these precise steps in vivo is genetically complex and involves the toxin-antitoxin module MazEF and the iron import protein TonB.by Susan E. Cohen.Ph.D

A behavioral comparison of male and female adults with high functioning autism spectrum conditions

Autism spectrum conditions (ASC) affect more males than females in the general population. However, within ASC it is unclear if there are phenotypic sex differences. Testing for similarities and differences between the sexes is important not only for clinical assessment but also has implications for theories of typical sex differences and of autism. Using cognitive and behavioral measures, we investigated similarities and differences between the sexes in age- and IQ-matched adults with ASC (high-functioning autism or Asperger syndrome). Of the 83 (45 males and 38 females) participants, 62 (33 males and 29 females) met Autism Diagnostic Interview-Revised (ADI-R) cut-off criteria for autism in childhood and were included in all subsequent analyses. The severity of childhood core autism symptoms did not differ between the sexes. Males and females also did not differ in self-reported empathy, systemizing, anxiety, depression, and obsessive-compulsive traits/symptoms or mentalizing performance. However, adult females with ASC showed more lifetime sensory symptoms (p = 0.036), fewer current socio-communication difficulties (p = 0.001), and more self-reported autistic traits (p = 0.012) than males. In addition, females with ASC who also had developmental language delay had lower current performance IQ than those without developmental language delay (p<0.001), a pattern not seen in males. The absence of typical sex differences in empathizing-systemizing profiles within the autism spectrum confirms a prediction from the extreme male brain theory. Behavioral sex differences within ASC may also reflect different developmental mechanisms between males and females with ASC. We discuss the importance of the superficially better socio-communication ability in adult females with ASC in terms of why females with ASC may more often go under-recognized, and receive their diagnosis later, than males

Relation between eating evoked by lateral hypothalamic stimulation and tail pinch in different rat strains

The similarity between the behaviors evoked by tail pinch (TP) and electrical stimulation of the lateral hypothalamus (ESLH) has been noted by many investigators. Evidence is presented for a possible inverse relationship between the probability that ESLH would evoke eating and the readiness to eat in response to TP in six different rat populations (High and Low lines of the LC1 and LC2 Hebrew University Strains, Sprague--Dawley, and Long--Evans). Discussion of these results emphasizes differences in intensity between ESLH and TP stimulation and differences in emotionality among rat populations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24047/1/0000296.pd

Language and social/emotional problems identified at a universal developmental assessment at 30 months

Non peer reviewedPublisher PD

Secrets of Successful Short Grant Applications

Nursing doctoral programs prepare students for research-focused careers within academic settings. The purpose of this Editorial Board Special Article is to provide PhD students and advisors with suggestions for making the most of their doctoral experience. Editorial Board members provide their individual insights on the skills and attributes students must acquire during the course of their doctoral education in order to succeed. The authors provide practical tips and advice on how to excel in a PhD program, including how to select an advisor and a dissertation committee, the importance of attending conferences to increase visibility and develop a network of colleagues, presenting and publishing research while still a student, and balancing work and personal life. Students who take full advantage of the opportunities available to them during the course of their doctoral programs will graduate well prepared to take on the multiple responsibilities of research, teaching, and leadership