Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma

Glioblastoma (GBM) is the most common and most aggressive intrinsic brain tumour in adults. Integrated transcriptomic and epigenomic analyses of glioblastoma initiating cells (GIC) in a mouse model uncovered a novel epigenetic regulation of EfnA5. In this model, Bmi1 enhances H3K27me3 at the EfnA5 locus and reinforces repression of selected target genes in a cellular context-dependent fashion. EfnA5 mediates Bmi1-dependent proliferation and invasion in vitro and tumour formation in an allograft model. Importantly, we show that this novel Polycomb feed-forward loop is also active in human GIC and we provide pre-clinical evidence of druggability of the EFNA5 signalling pathway in GBM xenografts overexpressing Bmi1

Transformers discover an elementary calculation system exploiting local attention and grid-like problem representation

Mathematical reasoning is one of the most impressive achievements of human intellect but remains a formidable challenge for artificial intelligence systems. In this work we explore whether modern deep learning architectures can learn to solve a symbolic addition task by discovering effective arithmetic procedures. Although the problem might seem trivial at first glance, generalizing arithmetic knowledge to operations involving a higher number of terms, possibly composed by longer sequences of digits, has proven extremely challenging for neural networks. Here we show that universal transformers equipped with local attention and adaptive halting mechanisms can learn to exploit an external, grid-like memory to carry out multi-digit addition. The proposed model achieves remarkable accuracy even when tested with problems requiring extrapolation outside the training distribution; most notably, it does so by discovering human-like calculation strategies such as place value alignment

Cause di stress e burnout negli insegnanti di educazione fisica

Il tema del burnout degli insegnanti \ue8 stato trattato in numerosi studi, ma solo poca attenzione \ue8 stata dedicata agli insegnanti di educazione fisica. In questo lavoro vengono presentati i risultati di una ricerca condotta in un campione di insegnanti di educazione fisica del Veneto, volta ad esplorare le principali cause di stress percepito e gli atteggiamenti nei confronti della propria professione. Conoscere le cause del burnout pu\uf2 permettere di individuare misure in grado di evitarlo

Il LOFOPT: una griglia di osservazione per l'attivit\uc3\ua0 fisica adattata con pazienti psichiatrici

Le attivit\ue0 fisiche stanno trovando sempre pi\uf9 spazio nei programmi terapeutici e riabilitativi per pazienti psichiatrici, purtroppo risultano sviluppati solo pochi strumenti per valutare l\u2019efficacia di queste attivit\ue0. In questo lavoro vengono presentate la versione italiana del Lofopt ed una esperienza clinica di utilizzo dello strumento. Il Lofopt (Louvain Observation Scale For Objectives in Psychomotor Therapy) \ue8 una griglia di osservazione, sviluppata all\u2019Universit\ue0 Cattolica di Lovanio in Belgio nel 1989, che appare particolarmente adattabile a diverse realt\ue0 operative e che mette in luce alcuni tra gli obiettivi pi\uf9 importanti delle terapia a mediazione corporea in psichiatria

Evaluation of a programme of adapted physical activity for eating disorders patients

The importance of work focused on body experience in the therapy of Eating Disorders is acknowledged by many authors. Nevertheless, only few researches have been devoted to this aspect of the therapy. The present work describes an experience of adapted physical activity out as part of a residential cure program for eating disorder patients, covering a sample of 96 patients. The chief aims of our adapted physical activity program concern four main areas: individual identity, relations with others, the body, and getting patients to build for themselves a correct image of physical activity. There is a wide variety of work tools, include both individual and group activities: movement exercise, adapted sports, dancing, expressive activities, relaxation. The following are used to evaluate results: individual and group talks, specific observation scales, and video recordings of some meetings. In common with other authors, the observations lead one to think that controlled physical activities would be a useful element for integrating into an eating disorders cure project