On the probability summation model for laser-damage thresholds

This paper explores the probability summation model in an attempt to provide insight to the model’s utility and ultimately its validity. The model is a statistical description of multiple-pulse (MP) damage trends. It computes the probability of n pulses causing damage from knowledge of the single-pulse dose–response curve. Recently, the model has been used to make a connection between the observed n−1∕4 trends in MP damage thresholds for short pulses (\u3c10 \u3eμs) and experimental uncertainties, suggesting that the observed trend is an artifact of experimental methods. We will consider the correct application of the model in this case. We also apply this model to the spot-size dependence of short pulse damage thresholds, which has not been done previously. Our results predict that the damage threshold trends with respect to the irradiated area should be similar to the MP damage threshold trends, and that observed spot-size dependence for short pulses seems to display this trend, which cannot be accounted for by the thermal models. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.21.1.015006

Developing Perfectly Matched Layer method to solve Heat Equation numerically

Perfectly Matched Layer (PML) techniques, although having been studied extensively to study systems with nonrestrictive boundaries in many physical fields, are not readily adaptable to the study of thermodynamic systems governed by the heat equation. Using the explicit finite difference method, we can easily describe systems with perfectly absorbing or reflecting boundaries. These, however, are highly idealized physical states, so we have begun extending our abilities to simulating more realistic physical situations by defining arbitrary spatial differential operators, which govern how heat at the boundaries of the system of interest propagates. As a first attempt, we transformed the linear spatial domain to a trigonometric domain to combat reflection from boundaries, but this is quite crude. We then approached the problem using Fourier Transforms in order to define the problem in a heat distribution\u27s frequency space, damp excessive heat past the boundaries, and transform back to position space. Initial results using the finite difference method verify the current computer simulation\u27s ability to solve problems with ideal circumstances, and the development of a PML method which accurately simulates nonrestrictive boundaries and can be easily translated into a computer algorithm is in progress

A Method for Coupling Monte Carlo Simulations of Photon Transport to Focused Gaussian Beam Propagation

We present a method for modeling focused Gaussian beams in turbid media. Compared to previous methods based on ray tracing, our method is simple and fast. Rather than sampling photon launch positions from the surface of the media, we directly sample launch positions from inside the sample volume using the probability distribution for the position that a ballistic photon will first interact with the tissue. The examples presented illustrate the importance of accounting for Gaussian beam optics when simulating a focused beam. Not doing so will give an artificially large irradiance at the beam waist position. Thermal models used to predict laser damage to tissue will predict temperature rises that are too large for samples containing the beam focus

BTEC Thermal Model

AFRL/RHDO has developed a configurable, laser-tissue interaction model that includes components from various areas of Biophysics. The model predicts heat transfer in biological tissue, in either one-dimension or two-dimensional cylindrical coordinates, and is coupled to an Arrhenius damage model. A simulation can be configured as a single run, or a damage-threshold search. Multiple models for describing the laser-tissue interaction are available, including linear absorption (1D, 2D), Monte Carlo scattering (2D) and Beam Propagation Methods using Finite Difference approximations or Hankel Transform methods (2D)

Infrared skin damage thresholds from 1319-nm continous-wave laser exposures

A series of experiments were conducted in vivo using Yucatan miniature pigs (Sus scrofa domestica) to determine thermal damage thresholds to the skin from 1319-nm continuous-wave Nd:YAG laser irradiation. Experiments employed exposure durations of 0.25, 1.0, 2.5, and 10 s and beam diameters of ∼0.6 and 1 cm. Thermal imagery data provided a time-dependent surface temperature response from the laser. A damage endpoint of fifty percent probability of a minimally visible effect was used to determine threshold for damage at 1 and 24 h postexposure. Predicted thermal response and damage thresholds are compared with a numerical model of opticalthermal interaction. Resultant trends with respect to exposure duration and beam diameter are compared with current standardized exposure limits for laser safety. Mathematical modeling agreed well with experimental data, predicting that though laser safety standards are sufficient for exposuress, they may become less safe for very long exposures. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.18.12.125002

The Probability Distribution of Binary Pulsar Coalescence Rates. I. Double Neutron Star Systems in the Galactic Field

Estimates of the Galactic coalescence rate (R) of close binaries with two neutron stars (NS-NS) are known to be uncertain by large factors (about two orders of magnitude) mainly due to the small number of systems detected as binary radio pulsars. We present an analysis method that allows us to estimate the Galactic NS-NS coalescence rate using the current observed sample and, importantly, to assign a statistical significance to these estimates and to calculate the allowed ranges of values at various confidence levels. The method involves the simulation of selection effects inherent in all relevant radio pulsar surveys and a Bayesian statistical analysis for the probability distribution of the rate. The most likely values for the total Galactic coalescence rate (R_peak) lie in the range 2-60 per Myr depending on different pulsar population models. For our reference model 1, where the most likely estimates of pulsar population properties are adopted, we obtain R_tot = 8_{-5}^{+9} per Myr at a 68% statistical confidence level. The corresponding range of expected detection rates of NS-NS inspiral are 3_{-2}^{+4}x10^{-3} per yr for the initial LIGO and 18_{-11}^{+21} per yr for the advanced LIGO.Comment: 28 pages including 7 figures, minor revisions, accepted for publication in the Astrophysical Journa

The Temporal Relationship Between the Coronavirus Disease 2019 (COVID-19) Pandemic and Preterm Birth

OBJECTIVE: To evaluate whether preterm birth rates changed in relation to the onset of the coronavirus disease 2019 (COVID-19) pandemic and whether any change depended on socioeconomic status. METHODS: This is an observational cohort study of pregnant individuals with a singleton gestation who delivered in the years 2019 and 2020 at 1 of 16 U.S. hospitals of the Maternal-Fetal Medicine Units Network. The frequency of preterm birth for those who delivered before the onset of the COVID-19 pandemic (ie, in 2019) was compared with that of those who delivered after its onset (ie, in 2020). Interaction analyses were performed for people of different individual- and community-level socioeconomic characteristics (ie, race and ethnicity, insurance status, Social Vulnerability Index (SVI) of a person\u27s residence). RESULTS: During 2019 and 2020, 18,526 individuals met inclusion criteria. The chance of preterm birth before the COVID-19 pandemic was similar to that after the onset of the pandemic (11.7% vs 12.5%, adjusted relative risk 0.94, 95% CI 0.86-1.03). In interaction analyses, race and ethnicity, insurance status, and the SVI did not modify the association between the epoch and the chance of preterm birth before 37 weeks of gestation (all interaction P \u3e.05). CONCLUSION: There was no statistically significant difference in preterm birth rates in relation to the COVID-19 pandemic onset. This lack of association was largely independent of socioeconomic indicators such as race and ethnicity, insurance status, or SVI of the residential community in which an individual lived

Encoding and maintaining reference in oral discourse.

International audienceThis study deals with information management and reference encoding modes in oral discourse production. Three potentially influential factors were the distance between the first occurrence of an item and its later occurrences, a topic change that takes the focus off that item, and the span of the conceptual information available for verbalization. French-speaking adult subjects were asked to tell stories from comic strips to a listener who was unfamiliar with them. The frames in each strip were presented simultaneously or in succession. Four versions were generated for each comic strip: a given version was either short (three frames) or long (eight frames), and either did or did not have a topic change. The results showed that the target character was usually marked as a given, regardless of the version. This was more often true, however, when the topic did not change. When the character was treated as a given, referent accessibility marking was dependent on (1) topic change alone when the frames were presented simultaneously, and (2) topic change and comic strip length when the frames were presented in succession. The discussion analyzes the results in terms of the allocation of cognitive resources to maintaining coreference and to assisting addressees in their processing

How Differences in Property Taxes within Cities Affect Urban Sprawl?

This article attempts a formal analysis of the connection between the differentiated property tax rates within urban areas and urban spatial pattern in U.S. cities. We first develop a duocentric-city model where the Central Business District (CBD) is located at the origin while the Suburban Business District (SBD) is at the other end of the city. We show that the ratio between the property tax in the suburbs and in the center has an ambiguous impact on the size of the city. We then test this model empirically to determine this sign by using a dataset of effective property tax rates we developed using GIS techniques for central cities and suburbs in 445 urbanized areas. The empirical analysis estimates the link between these two variables by controlling for variables such as population, income, agricultural rent, commuting cost, climate, crime, and employment structure. Results from the empirical analyses suggest that a lower property tax rate in the suburbs in comparison to the central city is associated with more expansive urban growth and greater level of decentralization of population and employment

Breeding progress and preparedness for mass‐scale deployment of perennial lignocellulosic biomass crops switchgrass, miscanthus, willow and poplar

UK: The UK‐led miscanthus research and breeding was mainly supported by the Biotechnology and Biological Sciences Research Council (BBSRC), Department for Environment, Food and Rural Affairs (Defra), the BBSRC CSP strategic funding grant BB/CSP1730/1, Innovate UK/BBSRC “MUST” BB/N016149/1, CERES Inc. and Terravesta Ltd. through the GIANT‐LINK project (LK0863). Genomic selection and genomewide association study activities were supported by BBSRC grant BB/K01711X/1, the BBSRC strategic programme grant on Energy Grasses & Bio‐refining BBS/E/W/10963A01. The UK‐led willow R&D work reported here was supported by BBSRC (BBS/E/C/00005199, BBS/E/C/00005201, BB/G016216/1, BB/E006833/1, BB/G00580X/1 and BBS/E/C/000I0410), Defra (NF0424) and the Department of Trade and Industry (DTI) (B/W6/00599/00/00). IT: The Brain Gain Program (Rientro dei cervelli) of the Italian Ministry of Education, University, and Research supports Antoine Harfouche. US: Contributions by Gerald Tuskan to this manuscript were supported by the Center for Bioenergy Innovation, a US Department of Energy Bioenergy Research Center supported by the Office of Biological and Environmental Research in the DOE Office of Science, under contract number DE‐AC05‐00OR22725. Willow breeding efforts at Cornell University have been supported by grants from the US Department of Agriculture National Institute of Food and Agriculture. Contributions by the University of Illinois were supported primarily by the DOE Office of Science; Office of Biological and Environmental Research (BER); grant nos. DE‐SC0006634, DE‐SC0012379 and DE‐SC0018420 (Center for Advanced Bioenergy and Bioproducts Innovation); and the Energy Biosciences Institute. EU: We would like to further acknowledge contributions from the EU projects “OPTIMISC” FP7‐289159 on miscanthus and “WATBIO” FP7‐311929 on poplar and miscanthus as well as “GRACE” H2020‐EU.3.2.6. Bio‐based Industries Joint Technology Initiative (BBI‐JTI) Project ID 745012 on miscanthus.Peer reviewedPostprintPublisher PD