51 research outputs found
Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers
Introduction: Linezolid is a last-resort antibiotic for infections caused by multidrug-resistant microorganisms. It is widely used for off-label indications and for longer than recommended treatment durations, exposing patients at higher risk of adverse drug reactions (ADRs), notably thrombocytopenia. This study aimed to investigate ADR incidence and risk factors, identify thrombocytopenia-related trough levels based on treatment duration, and evaluate the performance of predictive scores for ADR development.Methods: Adult in- and outpatients undergoing linezolid therapy were enrolled in three hospitals and ADRs and linezolid trough levels prospectively monitored over time. A population pharmacokinetic (pop-PK model) was used to estimate trough levels for blood samples collected at varying times.Results: A multivariate analysis based on 63 treatments identified treatment duration ≥10 days and trough levels >8 mg/L as independent risk factors of developing thrombocytopenia, with high trough values correlated with impaired renal function. Five patients treated for >28 days did not develop thrombocytopenia but maintained trough values in the target range (<8 mg/L). The Buzelé predictive score, which combines an age-adjusted Charlson comorbidity index with treatment duration, demonstrated 77% specificity and 67% sensitivity to predict the risk of ADR.Conclusion: Our work supports the necessity of establishing guidelines for dose adjustment in patients with renal insufficiency and the systematic use of TDM in patients at-risk in order to keep trough values ≤8 mg/L. The Buzelé predictive score (if ≥7) may help to detect these at-risk patients, and pop-PK models can estimate trough levels based on plasma samples collected at varying times, reducing the logistical burden of TDM in clinical practice
Reply to: ‘Clinical efficacy and safety of cefiderocol in the treatment of acute bacterial infections: a systematic review and meta-analysis of randomised controlled trials’
SCOPUS: le.jinfo:eu-repo/semantics/publishe
Pacemaker-related endocarditis inducing tricuspid stenosis
SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Comparative trends of brucellosis serological testing and confirmed brucellosis cases suggest inappropriate prescription habits
info:eu-repo/semantics/publishe
Infectious mononucleosis complicated by transverse myelitis: Detection of the viral genome by polymerase chain reaction in the cerebrospinal fluid [2]
SCOPUS: le.jinfo:eu-repo/semantics/publishe
Toxoplasma gondii septicemia without organ involvement in a toxo-seronegative AIDS patient
info:eu-repo/semantics/nonPublishe
Tyrothricin-containing oral tablets causing Clostridium difficile-associated diarrhea [1]
SCOPUS: le.jinfo:eu-repo/semantics/publishe
Intralesional injections of meglumine antimoniate to treat complex facial leishmania infantum acquired in Spain: a case report
SCOPUS: le.jinfo:eu-repo/semantics/publishe
COVID-19–Associated Fusobacterium nucleatum Bacteremia, Belgium
info:eu-repo/semantics/publishe
West Nile Virus Neuroinvasive Disease Accelerating Probable Dementia With Lewy Bodies.
We describe a case of dementia with Lewy bodies immediately following encephalitis due to West Nile virus (WNV). The patient had rapid eye movement-sleep behavior disorder and constipation before the onset of encephalitis, which suggests that he would have ultimately developed dementia with Lewy bodies even without WNV infection. Our case illustrates the interactions between α-synuclein and WNV, as observed in mouse models, wherein synuclein expression augments after WNV infection and protects neurons against the virus.info:eu-repo/semantics/publishe
- …