Efficacy and safety of deep brain stimulation for treatment-refractory anorexia nervosa: a systematic review and meta-analysis

Background: Several pioneering studies investigated deep brain stimulation (DBS) in treatment-refractory anorexia nervosa (AN) patients, but overall effects remain yet unclear. Aim of this study was to obtain estimates of efficacy of DBS in AN-patients using meta-analysis. Methods: We searched three electronic databases until 1st of November 2021, using terms related to DBS and AN. We included trials that investigated the clinical effects of DBS in AN-patients. We obtained data including psychiatric comorbidities, medication use, DBS target, and study duration. Primary outcome was Body Mass Index (BMI), secondary outcome was quality of life, and the severity of psychiatric symptoms, including eating disorder, obsessive-compulsive, depressive, and anxiety symptoms. We assessed the risk of bias using the ROBINS-I tool. Results: Four studies were included for meta-analysis, with a total of 56 patients with treatment-refractory AN. Follow-up ranged from 6–24 months. Random effects meta-analysis showed a significant increase in BMI following DBS, with a large effect size (Hedges’s g = 1 ∙ 13; 95% CI = 0 ∙ 80 to 1 ∙ 46; Z-value = 6 ∙ 75; P < 0 ∙ 001), without heterogeneity (I2= 0 ∙ 00, P = 0 ∙ 901). Random effects meta-analysis also showed a significant increase in quality of life (Hedges’s g = 0 ∙ 86; 95% CI = 0 ∙ 44 to 1 ∙ 28; Z-value = 4 ∙ 01, P < 0 ∙ 001). Furthermore, DBS decreased the severity of psychiatric symptoms (Hedges’s g = 0 ∙ 89; 95% CI = 0 ∙ 57 to 1 ∙ 21; Z-value = 5 ∙ 47; P < 0 ∙ 001, I2= 4 ∙ 29, P = 0 ∙ 371). Discussion: In this first meta-analysis, DBS showed statistically large beneficial effects on weight restoration, quality of life, and reduction of psychiatric symptoms in patients with treatment-refractory AN. These outcomes call for more extensive naturalistic studies to determine the clinical relevance for functional recovery. This study is preregistered in PROSPERO,CRD42022295712

Zesje: Web-based paper exam grading system

Grading can be a very time-consuming activity for teachers. For this reason, numerous tools exist to aid teachers in grading. One of these tools is Zesje, a web application that allows electronic grading of paper-based exams. A major drawback of Zesje was that teachers were required to create their exams with LaTeX, a popular document typesetting language. Having to use LaTeX meant two things: not being able to use other software to create exams and poor performance when compiling the LaTeX source. This report outlines the research, development, and evaluation of a project that involves the deprecation of the LaTeX template from the software stack of Zesje.Bachelor End ProjectComputer Scienc

New radiometric ages and seismic data from Fuerteventura (Canary Islands), Maio (Cape Verde Islands), and Sao Tome (Gulf of Guinea)

The early magmatic phase on the islands of Fuerteventura, Maio and Sao Tome ranges from Eocene to Middle Miocene. This conclusion is based on K-Ar datings, field observations and reflection seismic data which are all in good agreement. The three islands occur in different geological settings. The magmatic events are roughly synchronous and appear related in time to major unconformities on the continental margin of western Africa. They are also contemporaneous with major alpine orogenic events and cannot be connected with early opening stages of the Atlantic. A change in stress regime along the West African margin is probably in causal relationship with the collision of African and Eurasian continental masses. Deep-seated crustal deformation may have triggered off the early magmatic phase

Efficacy and safety of deep brain stimulation for treatment-refractory anorexia nervosa: a systematic review and meta-analysis

Background: Several pioneering studies investigated deep brain stimulation (DBS) in treatment-refractory anorexia nervosa (AN) patients, but overall effects remain yet unclear. Aim of this study was to obtain estimates of efficacy of DBS in AN-patients using meta-analysis. Methods: We searched three electronic databases until 1st of November 2021, using terms related to DBS and AN. We included trials that investigated the clinical effects of DBS in AN-patients. We obtained data including psychiatric comorbidities, medication use, DBS target, and study duration. Primary outcome was Body Mass Index (BMI), secondary outcome was quality of life, and the severity of psychiatric symptoms, including eating disorder, obsessive-compulsive, depressive, and anxiety symptoms. We assessed the risk of bias using the ROBINS-I tool. Results: Four studies were included for meta-analysis, with a total of 56 patients with treatment-refractory AN. Follow-up ranged from 6–24 months. Random effects meta-analysis showed a significant increase in BMI following DBS, with a large effect size (Hedges’s g = 1 ∙ 13; 95% CI = 0 ∙ 80 to 1 ∙ 46; Z-value = 6 ∙ 75; P < 0 ∙ 001), without heterogeneity (I2= 0 ∙ 00, P = 0 ∙ 901). Random effects meta-analysis also showed a significant increase in quality of life (Hedges’s g = 0 ∙ 86; 95% CI = 0 ∙ 44 to 1 ∙ 28; Z-value = 4 ∙ 01, P < 0 ∙ 001). Furthermore, DBS decreased the severity of psychiatric symptoms (Hedges’s g = 0 ∙ 89; 95% CI = 0 ∙ 57 to 1 ∙ 21; Z-value = 5 ∙ 47; P < 0 ∙ 001, I2= 4 ∙ 29, P = 0 ∙ 371). Discussion: In this first meta-analysis, DBS showed statistically large beneficial effects on weight restoration, quality of life, and reduction of psychiatric symptoms in patients with treatment-refractory AN. These outcomes call for more extensive naturalistic studies to determine the clinical relevance for functional recovery. This study is preregistered in PROSPERO,CRD42022295712

Longitudinal and Temporal Evolution of the Tectonic Style Along the Cyprus Arc System, Assessed Through 2-D Reflection Seismic Interpretation

International audienceThe Cyprus Arc system constitutes a major active plate boundary in the eastern Mediterranean region. This structure is directly linked with the northward convergence of the African and Eurasian plates since the Late Cretaceous. Two‐dimensional reflection seismic data were utilized, which image the main plate structures and their lateral evolution south of the island of Cyprus. Interpretation of these data allowed the identification of nine tectono‐sedimentary packages in three different crustal domains south of the Cyprus Arc system: (1) the Levant Basin (attenuated continental crust), (2) the Eratosthenes microcontinent (continental crust), and (3) the Herodotus Basin (oceanic crust). Within these domains, numerous tectonic structures were documented and analyzed in order to understand the mechanism and timing of deformation. In the north, south verging thrusting commenced in early Miocene along the Larnaca and Margat ridges, whereas no activity was identified before middle Miocene along the Latakia Ridge. Thus, the deformation front migrated southward and was accompanied by the development of flexural basins and stratigraphic onlaps as in the Cyprus Basin. The acme of deformation occurred in mid‐late Miocene. A regional unconformity of Pliocene age marks the end of the first deformation sequence. In Plio‐Pleistocene time, the westward escape of the Anatolian microplate resulted in the reactivation of existing structures. The evolution of deformation along the plate boundary is identified from the creation of positive flower structures revealing transpressive movements along the Larnaca and Latakia Ridges (eastern domains), whereas in the Eratosthenes domain a flexural basin highlights a compressive regime