Floppy modes and non-affine deformations in random fiber networks

We study the elasticity of random fiber networks. Starting from a microscopic picture of the non-affine deformation fields we calculate the macroscopic elastic moduli both in a scaling theory and a self-consistent effective medium theory. By relating non-affinity to the low-energy excitations of the network (``floppy-modes'') we achieve a detailed characterization of the non-affine deformations present in fibrous networks.Comment: 4 pages, 2 figures, new figure

Canonical quantization of a particle near a black hole

We discuss the quantization of a particle near an extreme Reissner-Nordstrom black hole in the canonical formalism. This model appears to be described by a Hamiltonian with no well-defined ground state. This problem can be circumvented by a redefinition of the Hamiltonian due to de Alfaro, Fubini and Furlan (DFF). We show that the Hamiltonian with no ground state corresponds to a gauge in which there is an obstruction at the boundary of spacetime requiring a modification of the quantization rules. The redefinition of the Hamiltonian a la DFF corresponds to a different choice of gauge. The latter is a good gauge leading to standard quantization rules. Thus, the DFF trick is a consequence of a standard gauge-fixing procedure in the case of black hole scattering.Comment: 13 pages, ReVTeX, no figure

Immunofunctional assay of human growth hormone (hGH) in serum: A possible consensus for quantitative hGH measurement

Confirmation of the diagnosis of GH deficiency in adults and children involves provocative testing for human (h) GH. Different commercially available immunoassays yield largely discrepant results in the measurement of GH levels in human serum. These discrepancies result in doubtful relevance of cut-off levels proposed for GH provocative testing. We have developed an immunofunctional assay method that allows quantitation of only those GH forms in circulation that possess both binding sites of the hormone for its receptor and thus can initiate a biological signal in target cells. An anti-hGH monoclonal antibody recognizing binding site 2 of hGH is immobilized and used to capture hGH from the serum sample. Biotin-labeled recombinant GH-binding protein in a second incubation step forms a complex with those hGH molecular isoforms that have both binding sites for the receptor. The signal is detected after a short third incubation step with labeled streptavidin. The assay is sensitive (detection range, 0.1-100 micrograms/L) and has average inter- and intraassay precisions of 10.3% and 7.3% respectively. Endogenous GH-binding protein does not interfere with the hGH result; placental lactogen slows no detectable cross-reaction in this immunofunctional assay. The degree of immunofunctionally active hGH forms in serum samples, calculated by comparison of immunofunctional assay and RIA results, varied between 52-93%. We propose this immunofunctional assay for GH measurement as a new reference method for hGH quantitation in serum. The immunofunction assay translates only hGH forms into an assay signal that are capable of dimerizing GH receptors and, thus, of initiating a biological effect in target cells

Conformal Theory of M2, D3, M5 and `D1+D5' Branes

The bosonic actions for M2, D3 and M5 branes in their own d-dimensional near-horizon background are given in a manifestly SO(p+1,2) x SO(d-p-1) invariant form (p=2,3,5). These symmetries result from a breakdown of ISO(d,2) (with d=10 for D3 and d=11 for M2 and M5) symmetry by the Wess-Zumino term and constraints. The new brane actions, reduce after gauge-fixing and solving constraints to (p+1) dimensional interacting field theories with a non-linearly realized SO(p+1,2) conformal invariance. We also present an interacting two-dimensional conformal field theory on a D-string in the near-horizon geometry of a D1+D5 configuration.Comment: 32 pages, two figures, Latex. A version to appear in JHEP. A comment is added on infinite dimensional Kac-Moody type symmetry of D1+D5 system observed by Brandt, Gomis, Sim'o

Quantum-to-classical transition for fluctuations in the early Universe

According to the inflationary scenario for the very early Universe, all inhomogeneities in the Universe are of genuine quantum origin. On the other hand, looking at these inhomogeneities and measuring them, clearly no specific quantum mechanical properties are observed. We show how the transition from their inherent quantum gravitational nature to classical behaviour comes about -- a transition whereby none of the successful quantitative predictions of the inflationary scenario for the present-day universe is changed. This is made possible by two properties. First, the quantum state for the spacetime metric perturbations produced by quantum gravitational effects in the early Universe becomes very special (highly squeezed) as a result of the expansion of the Universe (as long as the wavelength of the perturbations exceeds the Hubble radius). Second, decoherence through the environment distinguishes the field amplitude basis as being the pointer basis. This renders the perturbations presently indistinguishable from stochastic classical inhomogeneities.Comment: 9 pages, LATE

From vertex detectors to inner trackers with CMOS pixel sensors

The use of CMOS Pixel Sensors (CPS) for high resolution and low material vertex detectors has been validated with the 2014 and 2015 physics runs of the STAR-PXL detector at RHIC/BNL. This opens the door to the use of CPS for inner tracking devices, with 10-100 times larger sensitive area, which require therefore a sensor design privileging power saving, response uniformity and robustness. The 350 nm CMOS technology used for the STAR-PXL sensors was considered as too poorly suited to upcoming applications like the upgraded ALICE Inner Tracking System (ITS), which requires sensors with one order of magnitude improvement on readout speed and improved radiation tolerance. This triggered the exploration of a deeper sub-micron CMOS technology, Tower-Jazz 180 nm, for the design of a CPS well adapted for the new ALICE-ITS running conditions. This paper reports the R&D results for the conception of a CPS well adapted for the ALICE-ITS.Comment: 4 pages, 4 figures, VCI 2016 conference proceeding

Quantum Gravitational Contributions to the CMB Anisotropy Spectrum

We derive the primordial power spectrum of density fluctuations in the framework of quantum cosmology. For this purpose we perform a Born-Oppenheimer approximation to the Wheeler-DeWitt equation for an inflationary universe with a scalar field. In this way we first recover the scale-invariant power spectrum that is found as an approximation in the simplest inflationary models. We then obtain quantum gravitational corrections to this spectrum and discuss whether they lead to measurable signatures in the CMB anisotropy spectrum. The non-observation so far of such corrections translates into an upper bound on the energy scale of inflation.Comment: 4 pages, v3: sign error in Eq. (5) and its consequences correcte

Quantization of maximally-charged slowly-moving black holes

We discuss the quantization of a system of slowly-moving extreme Reissner-Nordstrom black holes. In the near-horizon limit, this system has been shown to possess an SL(2,R) conformal symmetry. However, the Hamiltonian appears to have no well-defined ground state. This problem can be circumvented by a redefinition of the Hamiltonian due to de Alfaro, Fubini and Furlan (DFF). We apply the Faddeev-Popov quantization procedure to show that the Hamiltonian with no ground state corresponds to a gauge in which there is an obstruction at the singularities of moduli space requiring a modification of the quantization rules. The redefinition of the Hamiltonian a la DFF corresponds to a different choice of gauge. The latter is a good gauge leading to standard quantization rules. Thus, the DFF trick is a consequence of a standard gauge-fixing procedure in the case of black hole scattering.Comment: Corrected errors in the gauge-fixing procedur

Origin of the inflationary Universe

We give a consistent description of how the inflationary Universe emerges in quantum cosmology. This involves two steps: Firstly, it is shown that a sensible probability peak can be obtained from the cosmological wave function. This is achieved by going beyond the tree level of the semiclassical expansion. Secondly, due to decoherence interference terms between different semiclassical branches are negligibly small. The results give constraints on the particle content of a unified theory.Comment: LATEX, 6 pages, selected for honorable mention in the 1999 Essay Competition of the Gravity Research Foundation. To appear in Mod. Phys. Lett.

Twenty five year follow-up for breast cancer incidence and mortality of the Canadian national breast screening study: randomised screening trial

Annual mammography in women aged 40-59 does not reduce mortality from breast cancer beyond that of physical examination or usual care when adjuvant therapy for breast cancer is freely available. Abstract Objective: To compare breast cancer incidence and mortality up to 25 years in women aged 40-59 who did or did not undergo mammography screening. Design: Follow-up of randomised screening trial by centre coordinators, the study’s central office, and linkage to cancer registries and vital statistics databases. Setting: 15 screening centres in six Canadian provinces,1980-85 (Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia). Participants: 89 835 women, aged 40-59, randomly assigned to mammography (five annual mammography screens) or control (no mammography). Interventions: Women aged 40-49 in the mammography arm and all women aged 50-59 in both arms received annual physical breast examinations. Women aged 40-49 in the control arm received a single examination followed by usual care in the community. Main outcome measure: Deaths from breast cancer. Results: During the five year screening period, 666 invasive breast cancers were diagnosed in the mammography arm (n=44 925 participants) and 524 in the controls (n=44 910), and of these, 180 women in the mammography arm and 171 women in the control arm died of breast cancer during the 25 year follow-up period. The overall hazard ratio for death from breast cancer diagnosed during the screening period associated with mammography was 1.05 (95% confidence interval 0.85 to 1.30). The findings for women aged 40-49 and 50-59 were almost identical. During the entire study period, 3250 women in the mammography arm and 3133 in the control arm had a diagnosis of breast cancer, and 500 and 505, respectively, died of breast cancer. Thus the cumulative mortality from breast cancer was similar between women in the mammography arm and in the control arm (hazard ratio 0.99, 95% confidence interval 0.88 to 1.12). After 15 years of follow-up a residual excess of 106 cancers was observed in the mammography arm, attributable to over-diagnosis. Conclusion: Annual mammography in women aged 40-59 does not reduce mortality from breast cancer beyond that of physical examination or usual care when adjuvant therapy for breast cancer is freely available. Overall, 22% (106/484) of screen detected invasive breast cancers were over-diagnosed, representing one over-diagnosed breast cancer for every 424 women who received mammography screening in the trial