The mother of all endocytosis

Massive endocytosis is initiated by a series of steps that involve a sudden influx of calcium ions, changes in mitochondria, and modification of surface proteins by lipids. A better understanding of this process could lead to new approaches to reducing the tissue damage that is caused by heart attacks

Sperm BerserKers

Human sperm cells rely on an unusual type of potassium ion channel

Empowering Girls with Chemistry, Exercise and Physical Activity

Research suggests that a girl\u27s career interests in the areas of science, technology, engineering and mathematics (STEM) declines between grades 6 and 8. Similarly, in middle school, there is a decrease in physical activity among girls. Researchers at the University of Rhode Island (URI) conducted a chemistry-based science camp that took place over the public school spring break with the goal of increasing girls\u27 interest in chemistry and physical activity. The camp included 42 middle school age girls in grades 6 through 8 from schools throughout Rhode Island. Interdisciplinary curricula were created to link chemistry with physical activity concepts used in physical education classes. Overall, the girls enjoyed the interdisciplinary curriculum and found the connection between science and physical activity to be interesting; as a result, similar science-based interdisciplinary curricula may have the capacity to promote physical activity as well as STEM career interests in girls

Calcium release from the nucleus by InsP3 receptor channels

AbstractThe nucleus is surrounded by a double membrane separating it from the cytoplasm. The perinuclear space is continuous with endoplasmic reticulum, and the nuclear outer membrane shares many features with the reticular membrane. We now show that inositol 1,4,5-trisphosphate (InsP3) receptors associated with the ] nucleus release Ca2+ from isolated Xenopus laevis oocyte nuclei. Electrophysiological measurements of the intracellular InsP3 receptor in its native membrane have not been possible on the fine filamentous endoplasmic reticulum. In this paper, we directly measure InsP3-dependent receptor channels in isolated nuclei. The nuclear InsP3 receptor is activated by InsP3 and modulated by Ca2+. The channel is weakly regulated by ATP, is mildly voltage dependent, and has a greater conductance with monovalent cations than with divalent cations

Effects of a Physical Education Supportive Curriculum and Technological Devices on Physical Activity

The purpose of this study was to examine the effects of a physical education supportive curriculum and technological devices, heart rate monitor (HRM) and pedometer (PED), on physical activity. A single-subject ABAB research design was used to examine amount and level of participation in physical activity among 106 suburban fourth and fifth graders during physical education class. A curriculum, which was pedagogically centered on the use of the technological devices, was also developed and studied. Six children from each group and the physical education teacher were interviewed. The results of a one-way ANCOVA indicated group differences between the supportive curriculum and technology for HRMs, PEDs, and increased physical activity

Talking Trash: Ethics, Sustainability, And Organizational Trust

In 1960 Americans generated 88.1 million tons (2.68 lbs./person/day) of municipal solid waste (MSW), by 2012 municipal solid waste increased to 250.9 million tons (4.38 lbs./person/day). The good news is that of the total MSW 5.6 million tons was recycled in 1960 and by 2012 the amount surged to 86.6 million tons. This real-world case (to protect privacy, names have been changed) chronicles the development of a strategic supply chain decision within a heavily regulated industry that is characterized by hybrid public/private organizations. It illustrates the importance of contract compliance and quality control assessment. In addition, it is heavily imbedded within the sustainability conversation. Finally, integral elements of the case are ethics and organizational trust, which, regardless of contract obligations, is essential in reciprocal relationships and community/customer support