Cardiovascular Events in Patients With Fabry Disease Natural History Data From the Fabry Registry

ObjectivesThese analyses were designed to determine the incidence of major cardiovascular (CV) events and the natural history of CV complications in patients with Fabry disease.BackgroundFabry disease, a genetic disorder caused by deficiency of alpha-galactosidase A activity, is associated with CV dysfunction.MethodsMajor CV events (myocardial infarction, heart failure, or cardiac-related death) were analyzed in 2,869 Fabry Registry patients during the natural history period (i.e., before enzyme replacement therapy or among patients who never received therapy). Multivariate logistic regression analyses were performed to identify significant predictors of CV events.ResultsEighty-three of 1,424 men (5.8%) and 54 of 1,445 women (3.7%) experienced CV events at mean ages of 45 and 54 years, respectively. Heart failure was the most common first CV event, reported by 50 men (3.5%) and 33 women (2.3%). Hypertension and left ventricular hypertrophy were the risk factors most strongly associated with CV events. When these parameters were used as covariates in logistic regression analyses, the odds ratio (OR) for hypertension in men was 7.8 (95% confidence interval [CI]: 2.1 to 28.6, p = 0.0019), and the OR for hypertension in women was 4.5 (95% CI: 1.6 to 12.3, p = 0.0037). The OR for left ventricular hypertrophy was 4.8 in men (95% CI: 1.03 to 22.2, p = 0.0463) and 8.2 in women (95% CI: 2.6 to 26.0, p = 0.0003).ConclusionsMajor CV events occurred in approximately 5% of Fabry Registry patients during the natural history period. All patients with Fabry disease should be monitored for possible CV risk factors, particularly hypertension and left ventricular hypertrophy

Public sentiment on the enactment of the saiban??in (jury) system in Japan

On May 21, 2009 Japan enacted the Saiban 'in (Jury) System where citizens were\ud required to be active participants in the criminal judicial system as jurors. The shift from\ud having no jury system to having the citizens participate directly in the criminal justice\ud system was an incredible leap that some were excited for some were uncertain about, and many were not prepared for.\ud By researching public opinion and polls, this thesis studies public sentiment\ud before and after the enactment of the saiban 'in system. At the beginning, it was a\ud concept too different from the past and the public???s initial response was unpopular.\ud However, the public shifted their opinion on their new societal roles once the new system was launched. When the new procedure was established, the implementation of the saiban 'in system was a success

Impact of Mechanical Stress on Total-Dose Effects in Bipolar Transistors

International audienceExperiments conducted at high and low dose rates show that the total dose response of bipolar linear integrated circuits is influenced by mechanical stress. The role of mechanical stress on enhanced low dose rate sensitivity is discussed

Impact of Mechanical Stress on Total-Dose Effects in Bipolar Transistors

International audienc