Unusual bound or localized states

We summarize unusual bound or localized states in quantum mechanics. Our guide through these intriguing phenomena is the classical physics of the upside-down pendulum. Taking advantage of the analogy between the corresponding Newton's equation of motion and the time-independent Schr\"{o}dinger equation, we discuss the zero-energy ground state in a three-dimensional, spatially oscillating, potential. Moreover, we focus on the effect of the attractive quantum anti-centrifugal potential that only occurs in a two-dimensional situation.Comment: 11 pages, 4 figure

Women’s march on London: The importance of sister marches

Ali Cirone, LSE Fellow in Political Economy in the Department of Government, reflects on the Women’s March on London which took place on the 21 January 2017

Choose your own adventure: my time as a capstone supervisor

In essence, MPA Capstone projects match a group second-year students to a client organisation, with the goal of producing an analytically rigorous and innovative report on a real-world policy issue. Over the course of the year, students are expected to apply the empirical and public policy skills learned in the MPA core curriculum, as well as utilise the wealth of advisory and academic resources the LSE has to offer

Enhanced Estimation of a Noisy Quantum Channel Using Entanglement

We discuss the estimation of channel parameters for a noisy quantum channel - the so-called Pauli channel - using finite resources. It turns out that prior entanglement considerably enhances the fidelity of the estimation when we compare it to an estimation scheme based on separable quantum states.Comment: 4 pages, 2 figure

Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future

Constitutively activated prosurvival pathways render cancer cells addicted to their effects. Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy. Primary effusion lymphomas (PELs) are very aggressive non-Hodgkin’s B cell lymphomas, whose pathogenesis is strictly linked to Kaposi’s sarcoma herpesvirus (KSHV) infection. Here we summarized previous studies from our and other laboratories exploring the cytotoxic effect of drugs inhibiting the main prosurvival pathways activated in PEL cells. Moreover, the immunogenicity of cell death, in terms of dendritic cell (DC) activation and their potential side effect on DCs, is discussed

Hyperglycemia triggers HIPK2 protein degradation

Homeodomain interacting protein kinase-2 (HIPK2) is an evolutionary conserved kinase that modulates several key molecular pathways to restrain tumor growth and induce p53-depending apoptotic cell-death in response to anticancer therapies. HIPK2 silencing in cancer cells leads to chemoresistance and cancer progression, in part due to p53 inhibition. Recently, hyperglycemia has been shown to reduce p53 phosphorylation at serine 46 (Ser46), the target residue of HIPK2, thus impairing p53 apoptotic function. Here we asked whether hyperglycemia could, upstream of p53, target HIPK2. We focused on the effect of high glucose (HG) on HIPK2 protein stability and the underlying mechanisms. We found that HG reduced HIPK2 protein levels, therefore impairing HIPK2-induced p53 apoptotic activity. HG-triggered HIPK2 protein downregulation was rescued by both proteasome inhibitor MG132 and by protein phosphatase inhibitors Calyculin A (CL-A) and Okadaic Acid (OA). Looking for the phosphatase involved, we found that protein phosphatase 2A (PP2A) induced HIPK2 degradation, as evidenced by directly activating PP2A with FTY720 or by silencing PP2A with siRNA in HG condition. The effect of PP2A on HIPK2 protein degradation could be in part due to hypoxia-inducible factor-1 (HIF-1) activity which has been previously shown to induce HIPK2 proteasomal degradation through several ubiquitin ligases. Validation analysed performed with HIF-1α dominant negative or with silencing of Siah2 ubiquitin ligase clearly showed rescue of HG-induced HIPK2 degradation. These findings demonstrate how hyperglycemia, through a complex protein cascade, induced HIPK2 downregulation and consequently impaired p53 apoptotic activity, revealing a novel link between diabetes/obesity and tumor resistance to therapies

Nonlinear Relaxation in Population Dynamics

We analyze the nonlinear relaxation of a complex ecosystem composed of many interacting species. The ecological system is described by generalized Lotka-Volterra equations with a multiplicative noise. The transient dynamics is studied in the framework of the mean field theory and with random interaction between the species. We focus on the statistical properties of the asymptotic behaviour of the time integral of the i-th population and on the distribution of the population and of the local field.Comment: 11 pages, 4 figures, in press in Int. Journal of Fractals (2001