The dawn of CAMP volcanism and its bearing on the end-Triassic carbon cycle disruption

The cause-and-effect relationship between the c. 201 Ma eruption of the Central Atlantic magmatic province (CAMP) and the end-Triassic abrupt climate change and mass extinction is at present based on controversial temporal correlations. Upper Triassic sedimentary strata underlying CAMP basalts in Morocco illustrate a clear mineralogical and geochemical fingerprint of early CAMP basaltic eruptions, namely unusually high contents of MgO (10-32 wt%) and of mafic clay minerals (11-84%). In the same rocks a coincident negative carbon-isotope excursion (CIE) is present, equivalent to the so-called 'initial negative CIE' recorded worldwide shortly before the Triassic-Jurassic boundary. The new data show that the onset of CAMP activity preceded the end-Triassic carbon cycle disruption and that the initial negative CIE is unequivocally synchronous with CAMP volcanism. The results of this study strongly support the hypothesis that the culmination of pollution of atmosphere and seawater by CAMP-derived volcanic gases was the proximate cause of the end-Triassic mass extinction. © 2014 The Geological Society of London

Role of specimen US for predicting resection margin status in breast conserving therapy

Aim. To assess the diagnostic accuracy of specimen ultrasound (US) for predicting resection margin status in women undergoing breast conserving therapy for US-detected cancer, having the histological findings as the reference standard. Patients and methods. A total of 132 consecutive patients (age range, 34-87 years; mean, 51 years) underwent breast-conserving surgery for US-detected invasive breast cancer. All surgical specimens underwent US examination. The presence of lesion within the specimen and its distance from the specimen margins were assessed considering a threshold distance between the lesion and specimen margins of 10 mm. US findings were then compared with the pathological ones and specimen US. Sensitivity, specificity, diagnostic accuracy, positive (PPV) and negative predictive values (NPV) for predicting histological margin status were evaluated, having the histological findings as the reference standard. Results. The histological examination detected invasive ductal carcinoma in 96/132 (73%) cases, invasive lobular carcinoma in 32/132 (24%), mucinous carcinoma in 4/132 (3%). The pathological margin analysis revealed 96/132 (73%) negative margins and 36 (27%) close/positive margins. US examination detected all 132 breast lesions within the surgical specimens. 110 (83%) negative margins and 22 (17%) positive margins were found on US. Sensitivity, specificity, diagnostic accuracy, PPV and NPV of 44%, 94%, 80%, 73% and 82%, respectively, were found for specimen US. Conclusions. Specimen US represents a time and cost saving imaging tool for evaluating the presence of US detected-breast lesion within surgical specimen and for predicting the histological margin status