Recent Advances in RNA Structure Determination by NMR

Despite recent advances in the solution of NMR structures of RNA and RNA‐ligand complexes, the rate limiting step remains the gathering of a large number of NOE and torsion restraints. Additional sources of information for structure determination of larger RNA molecules have recently become available, and it is possible to supplement NOE and J‐coupling data with the measurement of dipolar couplings and cross‐correlated relaxation rates in high‐resolution NMR spectroscopy.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153177/1/cpnc0707.pd