Information Requirements And Difficulties Experienced After Discharge In Day Surgery Patients: A Descriptive Cross-Sectional Survey

Objective: Day surgery procedures have increasingly been used nowadays as a result of improvements in surgical techniques, anesthesia and analgesia techniques and they are preferred for their benefits to the patient and to the healthcare system. However, it is known that day surgery patients may face many problems in the perioperative period. This research was conducted determin the difficulties experienced by day surgery patients and their information requirements. Material and Methods: The study was designed as a cross-sectional and descriptive survey. It was conducted in 2003 for a total of 12 months, with the participation of 230 patients who had surgery in urology, orthopedics, ear nose throat, ophthalmology, plastic surgery or general surgery clinics and were hospitalized in the day surgery unit of a university hospital in Ankara Province. Data were collected using "Patient's Personal Information and Knowledge Requirements" and "Difficulties Experienced After Hospital Discharge" forms. Results: The research results showed that day surgery patients had deficient knowledge regarding the day surgery process and they experienced problems after discharge at home especially within the first three postoperative days. Mainly, the problems were related to the surgical site and the respiratory, digestive, nervous, urinary and musculoskeletal systems. Conclusions: Day surgery patients experienced many problems in the postoperative period and their knowledge on the solution of these problems and the day surgery process was insufficient. Therefore, we recommend to give the patients and their relatives sufficiently detailed verbal and written information on the day surgery process.WoSScopu

Genetic Association Study Of Exfoliation Syndrome Identifies A Protective Rare Variant At Loxl1 And Five New Susceptibility Loci

Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A, have previously been associated with XFS. To further elucidate the genetic basis of XFS, we collected a global sample of XFS cases to refine the association at LOXL1, which previously showed inconsistent results across populations, and to identify new variants associated with XFS. We identified a rare protective allele at LOXL1 (p.Phe407, odds ratio (OR) = 25, P = 2.9 x 10(-14)) through deep resequencing of XFS cases and controls from nine countries. A genome-wide association study (GWAS) of XFS cases and controls from 24 countries followed by replication in 18 countries identified seven genome-wide significant loci (P < 5 x 10(-8)). We identified association signals at 13q12 (POMP), 11q23.3 (TMEM136), 6p21 (AGPAT1), 3p24 (RBMS3) and 5q23 (near SEMA6A). These findings provide biological insights into the pathology of XFS and highlight a potential role for naturally occurring rare LOXL1 variants in disease biology.Wo