Revealing Res Publica: The Architecture of Democracy

A town hall and square for Georgetown The Intention of this thesis is to explore how ideas of democracy can be revealed in architecture. Issues concerning the manner in which a democracy or representative government represents itself, as opposed to that of the autocratic structured government are central to beginning thesis study. This thesis will demonstrate that form is, indeed, informed by content in this opposition

Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes

Despite extensive analysis of pRB phosphorylation in vitro, how this modification influences development and homeostasis in vivo is unclear. Here, we show that homozygous Rb∆K4 and Rb∆K7 knock-in mice, in which either four or all seven phosphorylation sites in the C-terminal region of pRb, respectively, have been abolished by Ser/Thr-to-Ala substitutions, undergo normal embryogenesis and early development, notwithstanding suppressed phosphorylation of additional upstream sites. Whereas Rb∆K4 mice exhibit telomere attrition but no other abnormalities, Rb∆K7 mice are smaller and display additional hallmarks of premature aging including infertility, kyphosis, and diabetes, indicating an accumulative effect of blocking pRb phosphorylation. Diabetes in Rb∆K7 mice is insulin-sensitive and associated with failure of quiescent pancreatic β-cells to re-enter the cell cycle in response to mitogens, resulting in induction of DNA damage response (DDR), senescence-associated secretory phenotype (SASP), and reduced pancreatic islet mass and circulating insulin level. Pre-treatment with the epigenetic regulator vitamin C reduces DDR, increases cell cycle re-entry, improves islet morphology, and attenuates diabetes. These results have direct implications for cell cycle regulation, CDK-inhibitor therapeutics, diabetes, and longevity

Lea Ciavarra and Anne Marie Lubrano: Renovation/Innovation: A Design Collaboration on the Near Westside

Architecture Fall 2008 Lecture Series - November 18, 2008 at Slocum Hall. Anne Marie Lubrano and Lea Ciavarra G\u2795, Syracuse Architecture visiting critics and co-principals of lubrano ciavarra design (Brooklyn NY), share their work-in-progress projects on Syracuse\u27s Near Westside, including The Near Westside Community Information Center, three residential renovations, and one ground-up pre-fab house design. All projects are low-cost sustainably-designed proposals that highlight a truly multi-disciplinary team approach

Alumni Career Conversations with Lea Ciavarra and John Burse

In a session moderated by Dean Speaks, Lea Ciavarra from Lubrano Ciavarra Architects and John Burse from Mackey Mitchell Architects will discuss the area of “Designing for the Academic Setting” and address such topics as: What changes they have seen to projects within the academic space over the past few months. What other changes are expected and what does that mean for the field. What is the recruitment timeline for internships and full-time positions within 2021. GUESTS Lea Ciavarra graduated with a Bachelor of Arts in Mathematics and a minor in Art & Art History from Colgate University in 1991. She received her Master of Architecture in 1995 from Syracuse University. Lea has served on the School of Architecture’s Advisory Board since 2001 and was named the first female Chairperson in 2018. Co-founder of Lubrano Ciavarra Architects, Lea has been instrumental in leading such projects as the Harlem Day Charter School in Manhattan and the construction of a 50,000 sf K-8 charter school for Grand Concourse Academy in the Bronx. John Burse is a 1994 graduate of the B.Arch program at Syracuse University. John’s expertise as a design leader and Principal at Mackey Mitchell Architects in St. Louis, Missouri, includes such campus projects as student centers (including our own Schine Student Center), residence halls, performing arts, and campus master planning. His student center designs have been recognized by the Association of College Unions International’s Facility Design Award of Excellence. John is also a key contributor to the Syracuse Architecture Advisory Board