Planned Improvements to the Venus Global Reference Atmospheric Model

The Venus Global Reference Atmospheric Model (Venus-GRAM) is an engineering-level atmospheric model applicable for engineering design analyses, mission planning, and operational decision making. Missions to Venus have generated a wealth of atmospheric data, however, Venus-GRAM has not been updated since its development and release in 2005. GRAM upgrades and maintenance have depended on inconsistent and waning project-specific support. The NASA Science Mission Directorate (SMD) has agreed to provide funding support in Fiscal Year 2018 and 2019 to upgrade the GRAMs. This presentation will provide an overview of Venus-GRAM and the objectives, tasks, and milestones related to the GRAM upgrades

Status of Outer Planet Global Reference Atmospheric Model (GRAM) Upgrades

The inability to test planetary spacecraft in the flight environment prior to a mission requires engineers to rely on ground-based testing and models of the vehicle and expected environments. One of the most widely used engineering models of the atmosphere is the Global Reference Atmospheric Model (GRAM) developed and maintained by the NASA Marshall Space Flight Center (MSFC). The NASA Science Mission Directorate (SMD) has provided funding support to upgrade the GRAMs

Requirement for a Uroplakin 3a-like protein in the development of zebrafish pronephric tubule epithelial cell function, morphogenesis, and polarity

Uroplakin (UP)3a is critical for urinary tract development and function; however, its role in these processes is unknown. We examined the function of the UP3a-like protein Upk3l, which was expressed at the apical surfaces of the epithelial cells that line the pronephric tubules (PTs) of the zebrafish pronephros. Embryos treated with upk3l-targeted morpholinos showed decreased pronephros function, which was attributed to defects in PT epithelial cell morphogenesis and polarization including: loss of an apical brush border and associated phospho-ERM proteins, apical redistribution of the basolateral Na+/K+-ATPase, and altered or diminished expression of the apical polarity complex proteins Prkcz (atypical protein kinase C zeta) and Pard3 (Par3). Upk3l missing its C-terminal cytoplasmic domain or containing mutations in conserved tyrosine or proline residues did not rescue, or only partially rescued the effects of Upk3l depletion. Our studies indicate that Upk3l promotes epithelial polarization and morphogenesis, likely by forming or stimulating interactions with cytoplasmic signaling or polarity proteins, and that defects in this process may underlie the pathology observed in UP3a knockout mice or patients with renal abnormalities that result from altered UP3a expression. © 2012 Mitra et al

Correlated defects, metal-insulator transition, and magnetic order in ferromagnetic semiconductors

The effect of disorder on transport and magnetization in ferromagnetic III-V semiconductors, in particular (Ga,Mn)As, is studied theoretically. We show that Coulomb-induced correlations of the defect positions are crucial for the transport and magnetic properties of these highly compensated materials. We employ Monte Carlo simulations to obtain the correlated defect distributions. Exact diagonalization gives reasonable results for the spectrum of valence-band holes and the metal-insulator transition only for correlated disorder. Finally, we show that the mean-field magnetization also depends crucially on defect correlations.Comment: 4 pages RevTeX4, 5 figures include

Current Therapy in CKD Patients Can Affect Vitamin K Status

Chronic kidney disease (CKD) patients have a higher risk of cardiovascular (CVD) morbidity and mortality compared to the general population. The links between CKD and CVD are not fully elucidated but encompass both traditional and uremic-related risk factors. The term CKD-mineral and bone disorder (CKD-MBD) indicates a systemic disorder characterized by abnormal levels of calcium, phosphate, PTH and FGF-23, along with vitamin D deficiency, decreased bone mineral density or altered bone turnover and vascular calcification. A growing body of evidence shows that CKD patients can be affected by subclinical vitamin K deficiency; this has led to identifying such a condition as a potential therapeutic target given the specific role of Vitamin K in metabolism of several proteins involved in bone and vascular health. In other words, we can hypothesize that vitamin K deficiency is the common pathogenetic link between impaired bone mineralization and vascular calcification. However, some of the most common approaches to CKD, such as (1) low vitamin K intake due to nutritional restrictions, (2) warfarin treatment, (3) VDRA and calcimimetics, and (4) phosphate binders, may instead have the opposite effects on vitamin K metabolism and storage in CKD patients

Mars Global Reference Atmospheric Model (Mars-GRAM) Upgrades

The inability to test planetary spacecraft in the flight environment prior to a mission requires engineers to rely on ground-based testing and models of the vehicle and expected environments. One of the most widely used engineering models of the Martian atmosphere is the Mars Global Reference Atmospheric Model (Mars-GRAM) developed and maintained by the NASA Marshall Space Flight Center (MSFC). The NASA Science Mission Directorate (SMD) has provided funding support to upgrade the planetary GRAMs in Fiscal Year 2018 and 2019. This poster summarizes the upgrades that have been made to Mars-GRAM, the release status of Mars-GRAM, the new GRAMs that are under development, and future Mars-GRAM upgrade plans

APS Neutrino Study: Report of the Neutrino Astrophysics and Cosmology Working Group

In 2002, Ray Davis and Masatoshi Koshiba were awarded the Nobel Prize in Physics ``for pioneering contributions to astrophysics, in particular for the detection of cosmic neutrinos.'' However, while astronomy has undergone a revolution in understanding by synthesizing data taken at many wavelengths, the universe has only barely been glimpsed in neutrinos, just the Sun and the nearby SN 1987A. An entire universe awaits, and since neutrinos can probe astrophysical objects at densities, energies, and distances that are otherwise inaccessible, the results are expected to be particularly exciting. Similarly, the revolution in quantitative cosmology has heightened the need for very precise tests that depend on the effects of neutrinos, and prominent among them is the search for the effects of neutrino mass, since neutrinos are a small but known component of the dark matter. In this report, we highlight some of the key opportunties for progress in neutrino astrophysics and cosmology, and the implications for other areas of physics

Search for Free Decay of Negative Pions in Water and Light Materials

We report on a search for the free decay component of pi- stopped in water and light materials. A non-zero value of this would be an indication of anomalous nu_e contamination to the nu_e and nu_mu_bar production at stopped-pion neutrino facilities. No free decay component of pi- was observed in water, Beryllium, and Aluminum, for which upper limits were established at 8.2E-4, 3.2E-3, and 7.7E-3, respectively