Технологическая подготовка производства детали типа «Звездочка» на станках с ЧПУ

Целью выпускной квалификационной работы является совершенствование технологического процесса изготовления детали типа "Звездочка". В выпускной квалификационной работе рассмотрены четыре раздела: технологический, конструкторский, финансовый менеджмент и социальная ответственность. В технологическом разделе приведен проектный вариант технологического процесса изготовления детали и приведены необходимые расчеты. В конструкторском разделе представлено сконструированное станочное приспособление для фрезерного станка с ЧПУ. В разделе финансового менеджмента определена себестоимость проектирование технологического процесса.The goal of the final qualifying work is the improvement of the technological process of manufacturing the "Zvezdochka" type parts. In the final qualifying work, four sections were considered: technological, design, financial management and social responsibility. In the technological section, the design version of the technological process for manufacturing the part is given and the necessary calculations are given. In the design section, the machine tool for the CNC milling machine is presented. In the section of financial management, the cost of designing the process is determined

Leuprolide Acetate 1-Month Depot for Central Precocious Puberty: Hormonal Suppression and Recovery

Methods. This prospective US multicenter trial of leuprolide acetate 1-month depot (7.5–15 mg) for central precocious puberty utilized an open-label treatment period, long-term follow-up, and adult callback. Forty-nine females <9 years old with Tanner breast stage ≥2 before 8 years and 6 males <10 years old with Tanner genital stage ≥2 before 9 years with stimulated LH ≥10 IU/L and bone age advance ≥1 year were enrolled. Results. Subjects were treated for 3.9 ± 2.0 years. Mean peak GnRH-stimulated LH and FSH were prepubertal after the first dose and remained suppressed throughout treatment. During treatment, mean estradiol decreased to the limit of detection and mean testosterone decreased but remained above prepubertal norms. During posttreatment follow-up (3.5 ± 2.2 years), all patients achieved a pubertal hormonal response within 1 year and menses were reported in all females ≥12 years old. No impairment of reproductive function was observed at adulthood (mean age: 24.8 years)

Development of Soft-Hardware Platform for Training System Design of Electrotechnical Complexes and Electric Drives

The article presents the results of the development of software and hardware platform as the equipment for the training of children and youth work skills with robotics, allowing in the future to apply this knowledge in practice, implementing automation system for home use. We consider the problems of existing solutions. The main difference is the integration of the proposed fees and extensions into a single set by connecting the connectors and the ability to connect third-party components from different manufacturers, without limiting users. As well as a simplified method using a visual object-oriented programming allows you to immediately engage in the work. Prepared lessons and tasks in the game style simplifies the information and allows you to understand how you can apply one or another technical solution

Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)

Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands that exert clinically relevant tissue-selective progesterone agonist, antagonist, partial, or mixed agonist/antagonist effects on various progesterone target tissues in an in vivo situation depending on the biological action studied. The SPRM asoprisnil is being studied in women with symptomatic uterine leiomyomata and endometriosis. Asoprisnil shows a high degree of uterine selectivity as compared to effects on ovulation or ovarian hormone secretion in humans. It induces amenorrhea and decreases leiomyoma volume in a dose-dependent manner in the presence of follicular phase estrogen concentrations. It also has endometrial antiproliferative effects. In pregnant animals, the myometrial, i.e. labor-inducing, effects of asoprisnil are blunted or absent. Studies in non-human primates played a key role during the preclinical development of selective progesterone receptor modulators. These studies provided the first evidence of uterus-selective effects of asoprisnil and structurally related compounds, and the rationale for clinical development of asoprisnil

Автоматизированная беспроводная система измерений параметров окружающей среды

Объектом исследования является автоматизированная беспроводная система измерений параметров окружающей среды. Цель работы – является разработка автоматизированной беспроводной системы измерений параметров окружающей среды. В процессе исследования проводились: исследование областей применения системы измерений параметров окружающей среды, формирование требований к системе измерений, выбор измеряемых величин, разработка структуры и программного обеспечения системы. В результате исследования создана автоматизированная беспроводная система измерений параметров окружающей среды, которая измеряет температуру и относительную влажность окружающего воздуха, атмосферное давление и освещенность.The object of research is the automated wireless system of measurement of environmental parameters. The aim of this work is the development of an automated wireless system of measurement of environmental parameters. In the process studies were conducted: study of applications of the measurement system of environmental parameters, formation of requirements to the system of measurements, choice of measured value, design and development of software systems. The study established the automated wireless system of measurement of environmental parameters, which measures the temperature and relative humidity, atmospheric pressure and illuminance