Study on the development path of cultural tourism resources in Balikun reclamation

Balikun, known as the mother place of Han culture in Xinjiang, has rich cultural tourism resources and a good foundation for tourism development. It is one of the first counties to enter the list of national global tourism demonstration areas. Based on the analysis of Tunken culture and its tourism nature, this paper defines the concept of Tunken cultural tourism resources, and further excavates, classifies and analyzes the characteristics of Balikun Tunken cultural tourism resources. Based on the realistic basis of Balikun tourism development, this paper explores the realization path of the development of cultural tourism resources in Balikun from the perspective of global tourism

Resource utilization of microalgae from biological soil crusts::biodiesel production associated with desertification control

With the continuing consumption of resources and increasingly prominent environmental issues, microalgal resource utilization has received extensive attention. In this study, based on the microalgal investigation in desert biological soil crusts (BSCs) using pyrosequencing technology, the cultivated crust microalgae were further isolated in order to obtain high quality microalgae for resource utilization. The results showed that with crust development and succession, microalgal diversity gradually decreased, including the number of operational taxonomic units (OTUs) and genus, although Microcokus always was the dominant genera. Pyrosequencing obtained 630 OTUs of cyanobacteria, 25 OTUs of green algae and 9 OTUs of diatom; however, part of cultivated microalgae still could not yet be detected due to the DNA extraction preferences and errors caused by PCR amplification. After isolation, four strains were purified and cultivated, including two filamentous cyanobacteria Microcoleus vaginatus BSC-06 and Scytonema javanicum BSC-39, and two unicellular green algae Chlorella sp. BSC-24 and Monoraphidium dybowskii BSC-81. The two green algae grew fast (> 250 mg L-1 d(-1)), and achieved high lipid productivity up to 75-85 mg L-1 d(-1), with lipid content of 28.7-39.0%, thus was considered as promising feedstock for biodiesel production. In addition, the two crust cyanobacteria could be used to construct artificial cyanobacterial soil crusts in desertification control, although their biomass accumulation was not as high as that in the green algae. Ultimately, combining biodiesel production with desertification control would not only improve desert environments, but also provide ideal places for the local microalgal resource exploitation, further promoting desert socioeconomic development

Ischemic Stroke in Pontine and Corona Radiata: Location Specific Impairment of Neural Network Investigated With Resting State fMRI

Objective: This study aims to investigate location-specific functional remodeling following ischemic stroke in pons and corona radiata.Methods: This study was approved by the local Institutional Review Board. Written consent was obtained from each of the participants prior to the MRI examination. Thirty six subjects with first ever acute ischemic stroke in pons (PS, n = 15, aged 62.8 ± 11.01 years) or corona radiata (CRS, n = 21, aged 59.33 ± 13.84 years) as well as 30 age and sex matched healthy controls (HC, n = 30, aged 60 ± 6.43 years) were examined with resting state functional magnetic resonance imaging (rs-fMRI). Regional homogeneity (ReHo) and degree centrality (DC) were calculated using a voxel-based approach. Intergroup differences in ReHo and DC were explored using a permutation test with a threshold-free cluster enhancement (PT TFCE, number of permutations = 1,000, family-wise error rate (FWER) < 0.05).Results: ReHo and DC alterations were identified in distributed anatomies for both PS and CRS groups. DC mainly increased in the bilateral anterior and posterior cingulate cortex, the inferior frontal-orbital gyrus, and decreased in the bilateral cuneus, calcarine, and the precuneus, while ReHo mainly decreased in the precentral and the postcentral gyri, inferior parietal lobules, precuneus, posterior cingulate cortex, and the superior occipital gyrus. PS and CRS groups were not significantly different in ReHo or DC (FWER > 0.05).Conclusions: Focal ischemic stroke in pons or corona radiata leads to extensive alterations in the functional network centrality. IS-induced network remodeling is more anatomy-specific than pathway-specific, which may underpin the clinicotopographical profiles during the disease dynamic. Approaches targeting neural pathway and functional connectivity may shed light on a better characterization and management innovation of ischemic stroke

Fabrication and magnetic properties of Sm2Co17 and Sm2Co17/Fe7Co3 magnetic nanowires via AAO templates

AbstractThe Sm2Co17 single-phase and Sm2Co17/Fe7Co3 double-phase nanowire arrays with smaller diameter (around 50nm) have been fabricated into the anodic aluminum oxide (AAO) templates by direct-current electrodeposition. The crystal structure and micrograph of these nanowire arrays were characterized by X-ray diffraction, field-emission scanning electron microscopy and transmission electron microscopy (TEM). It is found that the as-deposited Sm2Co17 nanowires have the amorphous microstructure. The magnetic hysteresis loops obtained by vibrating sample magnetometer (VSM) show that the easily magnetized direction of the Sm2Co17 single-phase and Sm2Co17/Fe7Co3 double-phase nanowire arrays is parallel to the nanowire arrays and the exchange coupling interaction in nanocomposite Sm2Co17/Fe7Co3 is discussed. The study of the Sm2Co17 single-phase and Sm2Co17/Fe7Co3 double-phase nanowires with small diameter may open up new opportunities for the design and control of nanostructures such as the fabrication of magnetic recording devices

Preparation and Characterization of Mesoporous Zirconia Made by Using a Poly (methyl methacrylate) Template

Superfine powders of poly (methyl methacrylate) (PMMA) have been prepared by means of an emulsion polymerization method. These have been used as templates in the synthesis of tetragonal phase mesoporous zirconia by the sol–gel method, using zirconium oxychloride and oxalic acid as raw materials. The products have been characterized by infrared spectroscopy, X-ray diffraction analysis, transmission electron microscopy, N2adsorption-desorption isotherms, and pore size distribution. The results indicate that the average pore size was found to be 3.7 nm

MicroRNA-486 Alleviates Hypoxia-Induced Damage in H9c2 Cells by Targeting NDRG2 to Inactivate JNK/C-Jun and NF-κB Signaling Pathways

Background/Aims: Acute myocardial infarction is a serious disease with high morbidity and mortality. microRNAs (miRNAs) have been proved to play an important role in modulating myocardial ischemia and reperfusion injury. Hence, in this study, we constructed H9c2 cell model to elucidate the roles of microRNA-486 (miR-486) in preventing hypoxia-induced damage in H9c2 cells. Methods: H9c2 cells were cultured in hypoxic incubator with 1% O2 to simulate hypoxia and/or transfected with miR-486 mimic, scramble, anti-miR-486, si-N-myc downstream-regulated gene 2 (NDRG2) and their corresponding negative controls (NC). Effects of miR-486 and/or NDRG2 dysregulation on hypoxia-induced myocardial injury in H9c2 cells were investigated by evaluating cell viability, migration, invasion and apoptosis using Cell Counting Kit-8 (CCK-8), transwell assay, flow cytometry, respectively. The proteins expression and RNA expression were detected by western blot and quantitative real time polymerase chain reaction (qRT-PCR), respectively. Results: Hypoxia treatment induced damage in H9c2 cells by decreasing cell viability, migration and invasion and increasing cell apoptosis. Moreover, hypoxia inhibited the expression of miR-486 in H9c2 cells. Overexpression of miR-486 alleviated hypoxia-induced myocardial injury in H9c2 cells, while suppression of miR-486 further aggravated hypoxia-induced injury. Furthermore, NDRG2 expression was negatively regulated by miR-486, and NDRG2 was confirmed as a target of miR-486. Knockdown of NDRG2 alleviated the effects of miR-486 suppression on hypoxia-induced myocardial injury. Besides, knockdown of NDRG2 markedly inhibited the activation of c-Jun N-terminal kinase (JNK) /c-jun and nuclear factor κB (NF-κB) signaling pathways in hypoxia-induced H9c2 cells. Conclusion: Our findings indicate that miR-486 may alleviate hypoxia-induced myocardial injury possibly by targeting NDRG2 to inactivate JNK/c-jun and NF-κB signaling pathways. miR-486 may be a potential target for treating ischemic myocardial injury following acute myocardial infarction

Coping strategies following the diagnosis of a fetal anomaly: A scoping review

IntroductionMany women experience severe emotional distress (such as grief, depression, and anxiety) following a diagnosis of fetal anomaly. The ability to cope with stressful events and regulate emotions across diverse situations may play a primary role in psychological wellbeing. This study aims to present coping strategies after disclosing a fetal anomaly to pregnant women.MethodsThis is a scoping review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews (PRISMA-ScR). Electronic databases, including Web of Science (WOS, BCI, KJD, MEDLINE, RSCI, SCIELO), CINAHL, and EBSCO PsycARTICLES, were used to search for primary studies from the inception of each database to 2021. The keywords were determined by existing literature and included: “fetal anomaly,” “fetal abnormality,” “fetal anomaly,” “fetal abnormality” AND “cope,” “coping,” “deal,” “manage,” “adapt*,” “emotion* regulate*,” with the use of Boolean operators AND/OR. A total of 16 articles were reviewed, followed by advancing scoping review methodology of Arksey and O'Malley's framework.ResultsIn this review, we identified 52 coping strategies using five questionnaires in seven quantitative studies and one mixed-method study. The relationship between coping strategies and mental distress was explored. However, the results were inconsistent and incomparable. We synthesized four coping categories from qualitative studies and presented them in an intersection.ConclusionThis scoping review identified the coping strategies of women with a diagnosis of a fetal anomaly during pregnancy. The relationship between coping strategies and mental distress was uncertain and needs more exploration. We considered an appropriate measurement should be necessary for the research of coping in women diagnosed with fetal anomaly pregnancy