Successful Treatment of Biliary Atresia in Very Small Infants through Living Related Liver Transplantation

Improving outcomes in very small children is a major goal of pediatric liver transplantation. This report describes our experience of living related liver transplantation in an infant weighing 3.98 kg. The recipient, a 80-day-old male infant with congenital biliary atresia, was treated with living donor liver transplantation and then followed up for 6 months. The left lateral segment (segment II, III) with reduced size from the donor, his 26-year-old mother, was used as the graft. The graft weighed 200 g. The graft weight to recipient body weight ratio was 5.025%. The donor regained her liver function within 3 days and was discharged on day 8. The patient showed good results. Liver function returned to normal 9 days after the operation with bilirubin level almost decreased to normal. Cyclosporin, mycophenolate mofetil and prednisone were used for postoperative immunosuppression. No bleeding, thrombosis, infection or bile leakage occurred. The patient had slight fever because of a little collection in the abdomen and recovered after paracentesis and drainage. He was discharged on day 16. The donor and recipient are in satisfactory condition at present. Improvement of technique in hepatic surgery, microsurgical technique in vascular surgery and postoperative intensive care are the keys to ensure the success of the procedure

Effect of Variable Properties and Moving Heat Source on Magnetothermoelastic Problem under Fractional Order Thermoelasticity

A one-dimensional generalized magnetothermoelastic problem of a thermoelastic rod with finite length is investigated in the context of the fractional order thermoelasticity. The rod with variable properties, which are temperature-dependent, is fixed at both ends and placed in an initial magnetic field, and the rod is subjected to a moving heat source along the axial direction. The governing equations of the problem in the fractional order thermoelasticity are formulated and solved by means of Laplace transform in tandem with its numerical inversion. The distributions of the nondimensional temperature, displacement, and stress in the rod are obtained and illustrated graphically. The effects of the temperature-dependent properties, the velocity of the moving heat source, the fractional order parameter, and so forth on the considered variables are concerned and discussed in detail, and the results show that they significantly influence the variations of the considered variables

Effect of Variable Properties and Moving Heat Source on Magnetothermoelastic Problem under Fractional Order Thermoelasticity

A one-dimensional generalized magnetothermoelastic problem of a thermoelastic rod with finite length is investigated in the context of the fractional order thermoelasticity. The rod with variable properties, which are temperature-dependent, is fixed at both ends and placed in an initial magnetic field, and the rod is subjected to a moving heat source along the axial direction. The governing equations of the problem in the fractional order thermoelasticity are formulated and solved by means of Laplace transform in tandem with its numerical inversion. The distributions of the nondimensional temperature, displacement, and stress in the rod are obtained and illustrated graphically. The effects of the temperature-dependent properties, the velocity of the moving heat source, the fractional order parameter, and so forth on the considered variables are concerned and discussed in detail, and the results show that they significantly influence the variations of the considered variables

Outcome of the Pediatric Patients with Portal Cavernoma: The Retrospective Study for 10 Years Focusing on Recurrent Variceal Bleeding

Background. Portal cavernoma (PC) is the most critical condition with risk or variceal hemorrhage in pediatric patients. We retrospectively investigated the patients with PC focusing on the predictors for recurrent variceal bleeding. Methods. Between July 2003 and June 2013, we retrospectively enrolled all consecutive patients admitted to our department with a diagnosis of PC without abdominal malignancy or liver cirrhosis. The primary endpoint of this observational study was recurrent variceal bleeding. Independent predictors of recurrent variceal bleeding were identified using the logistic regression model. Results. A total of 157 patients were enrolled in the study. During the follow-up period, 24 patients exhibited onset of recurrent variceal bleeding. Acute variceal bleeding was subjected to conservative symptomatic treatment and emergency endoscopic sclerotherapy. Surgical procedure selection was based on the severity of vascular dilation and collateral circulation. Multivariate logistic regression analysis demonstrated that the presence of ascites, collateral circulation, and portal venous pressure were independent prognostic factors of recurrent variceal bleeding for patients with portal cavernoma. Conclusions. The presence of ascites, collateral circulation, and portal venous pressure evaluation are important and could predict the postsurgical recurrent variceal bleeding in patients with portal cavernoma

The Role of Thyroid Transcription Factor-1 DNA Binding Activity in Lung Cancer

Background and objective TTF-1 is a homeodomain transcriptional regulator of both structural organization of the lung and differentiation of highly specialized epithelial cell types such as alveolar typeⅡcells. This study is to investigate the Thyroid transcription factor-1 (TTF-1) DNA binding activity in lung cancer tissue and its significance with lung cancer pathologic type and differentiation level. Methods The TTF-1 DNA binding activity wasdetected in lung cancer tissue by Electrophoretic mobility shift assay (EMSA), autoradiography and photo densitometry. Results The optical density of TTF-1 DNA binding activity in adenocarcinoma tissue was 172±23.2 and it was remarkably higher than that in other pathological types, including 141±16.3 of small cell carcinomas and 122±13.6 of squamous carcinoma (P <0.05). The optical density of TTF-1 DNA binding activity in highly differentiated lung cancer tissues was significantly higher than that in poor-differentiated lung cancer (P <0.05). Overall survival and disease-free survival rates were better among patients with low TTF-1 DNA binding activity levels than those in patients with high levels. Conclusion TTF-1 DNA binding activity is a potential predictor of lung cancer metastasis and survival