111 research outputs found
Quark energy loss and shadowing in nuclear Drell-Yan process
The energy loss effect in nuclear matter is another nuclear effect apart from
the nuclear effects on the parton distribution as in deep inelastic scattering
process. The quark energy loss can be measured best by the nuclear dependence
of the high energy nuclear Drell-Yan process. By means of three kinds of quark
energy loss parameterizations given in literature and the nuclear parton
distribution extracted only with lepton-nucleus deep inelastic scattering
experimental data, measured Drell-Yan production cross sections are analyzed
for 800GeV proton incident on a variety of nuclear targets from FNAL E866. It
is shown that our results with considering the energy loss effect are much
different from these of the FNAL E866 who analysis the experimental data with
the nuclear parton distribution functions obtained by using the deep inelastic
lA collisions and pA nuclear Drell-Yan data . Considering the existence of
energy loss effect in Drell-Yan lepton pairs production,we suggest that the
extraction of nuclear parton distribution functions should not include
Drell-Yan experimental data.Comment: 12 page
Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time
10.2147/CIA.S32513Clinical Interventions in Aging7303-31
Changes in microarchitectural characteristics at the tibial epiphysis induced by collagen-induced rheumatoid arthritis over time
10.2147/CIA.S35202Clinical Interventions in Aging7373-38
Shifting a Quantum Wire through a Disordered Crystal: Observation of Conductance Fluctuations in Real Space
A quantum wire is spatially displaced by suitable electric fields with
respect to the scatterers inside a semiconductor crystal. As a function of the
wire position, the low-temperature resistance shows reproducible fluctuations.
Their characteristic temperature scale is a few hundred millikelvin, indicating
a phase-coherent effect. Each fluctuation corresponds to a single scatterer
entering or leaving the wire. This way, scattering centers can be counted one
by one.Comment: 4 pages, 3 figure
The Leptonic Higgs as a Messenger of Dark Matter
We propose that the leptonic cosmic ray signals seen by PAMELA and ATIC
result from the annihilation or decay of dark matter particles via states of a
leptonic Higgs doublet to leptons, linking cosmic ray signals of dark
matter to LHC signals of the Higgs sector. The states of the leptonic Higgs
doublet are lighter than about 200 GeV, yielding large and
event rates at the LHC. Simple models are
given for the dark matter particle and its interactions with the leptonic
Higgs, for cosmic ray signals arising from both annihilations and decays in the
galactic halo. For the case of annihilations, cosmic photon and neutrino
signals are on the verge of discovery.Comment: 34 pages, 9 figures, minor typos corrected, references adde
Nuclear effects on J/{\psi} production in proton-nucleus collisions
The study of nuclear effects for J/{\psi} production in proton-nucleus
collisions is crucial for a correct interpretation of the J/{\psi} suppression
patterns experimentally observed in heavy-ion collisions. By means of three
representative sets of nuclear parton distribution, the energy loss effect in
the initial state and the nuclear absorption effect in the final state are
taken into account in the uniform framework of the Glauber model. A leading
order phenomenological analysis is performed on J/{\psi} production
cross-section ratios RW/Be(xF) for the E866 experimental data. The J/{\psi}
suppression is investigated quantitatively due to the different nuclear
effects. It is shown that the energy loss effect with resulting in the
suppression on RW/Be(xF) is more important than the nuclear effects on parton
distributions in high xF region. The E866 data in the small xF keep out the
nuclear gluon distribution with a large anti-shadowing effect. However, the new
HERA-B measurement is not in support of the anti-shadowing effect in the
nuclear gluon distribution. It is found that the J/{\psi}-nucleon inelastic
cross section {\sigma} J/{\psi} abs depends on the kinematical variable xF, and
increases as xF in the region xF > 0.2. 1 Introductio
Structure-activity investigation of a G protein-biased agonist reveals molecular determinants for biased signaling of the D2 dopamine receptor
The dopamine D2 receptor (D2R) is known to elicit effects through activating two major signaling pathways mediated by either G proteins (Gi/o) or β-arrestins. However, the specific role of each pathway in physiological or therapeutic activities is not known with certainty. One approach to the dissection of these pathways is through the use of drugs that can selectively modulate one pathway vs. the other through a mechanism known as functional selectivity or biased signaling. Our laboratory has previously described a G protein signaling-biased agonist, MLS1547, for the D2R using a variety of in vitro functional assays. To further evaluate the biased signaling activity of this compound, we investigated its ability to promote D2R internalization, a process known to be mediated by β-arrestin. Using multiple cellular systems and techniques, we found that MLS1547 promotes little D2R internalization, which is consistent with its inability to recruit β-arrestin. Importantly, we validated these results in primary striatal neurons where the D2R is most highly expressed suggesting that MLS1547 will exhibit biased signaling activity in vivo. In an effort to optimize and further explore structure-activity relationships (SAR) for this scaffold, we conducted an iterative chemistry campaign to synthesize and characterize novel analogs of MLS1547. The resulting analysis confirmed previously described SAR requirements for G protein-biased agonist activity and, importantly, elucidated new structural features that are critical for agonist efficacy and signaling bias of the MLS1547 scaffold. One of the most important determinants for G protein-biased signaling is the interaction of a hydrophobic moiety of the compound with a defined pocket formed by residues within transmembrane five and extracellular loop two of the D2R. These results shed new light on the mechanism of biased signaling of the D2R and may lead to improved functionally-selective molecules
PAMELA/ATIC anomaly from the meta-stable extra dark matter component and the leptophilic Yukawa interaction
We present a supersymmetric model with two dark matter (DM) components
explaining the galactic positron excess observed by PAMELA/HEAT and
ATIC/PPB-BETS: One is the conventional (bino-like) lightest supersymmetric
particle (LSP) \chi, and the other is a TeV scale meta-stable neutral singlet
N_D, which is a Dirac fermion (N,N^c). In this model, N_D decays dominantly
into \chi e^+e^- through an R parity preserving dimension 6 operator with the
life time \tau_N\sim 10^{26} sec. We introduce a pair of vector-like superheavy
SU(2) lepton doublets (L,L^c) and lepton singlets (E,E^c). The dimension 6
operator leading to the N_D decay is generated from the leptophilic Yukawa
interactions by W\supset Ne^cE+Lh_dE^c+m_{3/2}l_1L^c with the dimensionless
couplings of order unity, and the gauge interaction by {\cal L}\supset \sqrt{2}
g'\tilde{e}^{c*}e^c\chi + h.c. The superheavy masses of the vector-like leptons
(M_L, M_E\sim 10^{16} GeV) are responsible for the longevity of N_D. The low
energy field spectrum in this model is just the MSSM fields and N_D. Even for
the case that the portion of N_D is much smaller than that of \chi in the total
DM density [{\cal O}(10^{-10}) \lesssim n_{N_D}/n_\chi], the observed positron
excess can be explained by adopting relatively lighter masses of the
vector-like leptons (10^{13} GeV \lesssim M_{L,E} \lesssim 10^{16} GeV). The
smallness of the electron mass is also explained. This model is easily embedded
in the flipped SU(5) grand unification, which is a leptophilic unified theory.Comment: 12 pages, published versio
Dark matter and collider phenomenology of split-UED
We explicitly show that split-universal extra dimension (split-UED), a
recently suggested extension of universal extra dimension (UED) model, can
nicely explain recent anomalies in cosmic-ray positrons and electrons observed
by PAMELA and ATIC/PPB-BETS. Kaluza-Klein (KK) dark matters mainly annihilate
into leptons because the hadronic branching fraction is highly suppressed by
large KK quark masses and the antiproton flux agrees very well with the
observation where no excess is found . The flux of cosmic gamma-rays from pion
decay is also highly suppressed and hardly detected in low energy region (E<20
GeV). Collider signatures of colored KK particles at the LHC, especially q_1
q_1 production, are studied in detail. Due to the large split in masses of KK
quarks and other particles, hard p_T jets and missing E_T are generated, which
make it possible to suppress the standard model background and discover the
signals.Comment: 32 pages, 15 figure
Impact of chronic obstructive pulmonary disease and dyspnoea on clinical outcomes in ticagrelor treated patients undergoing percutaneous coronary intervention in the randomized GLOBAL LEADERS trial
AIMS: To evaluate long-term safety and efficacy of ticagrelor monotherapy in patients undergoing percutaneous coronary interventions (PCIs) in relation to chronic obstructive pulmonary disease (COPD) at baseline and the occurrence of dyspnoea reported as adverse event (AE) that may lead to treatment non-adherence. METHODS AND RESULTS: This is a non-prespecified, post hoc analysis of the randomized GLOBAL LEADERS trial (n = 15 991), comparing the experimental strategy of 23-month ticagrelor monotherapy following 1-mo
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