Study on Semantic Contrast Evaluation Based on Vector and Raster Data Patch Generalization

We used buffer superposition, Delaunay triangulation skeleton line, and other methods to achieve the aggregation and amalgamation of the vector data, adopted the method of combining mathematical morphology and cellular automata to achieve the patch generalization of the raster data, and selected the two evaluation elements (namely, semantic consistency and semantic completeness) from the semantic perspective to conduct the contrast evaluation study on the generalization results from the two levels, respectively, namely, land type and map. The study results show that: (1) before and after the generalization, it is easier for the vector data to guarantee the area balance of the patch; the raster data’s aggregation of the small patch is more obvious. (2) Analyzing from the scale of the land type, most of the land use types of the two kinds of generalization result’s semantic consistency is above 0.6; the semantic completeness of all types of land use in raster data is relatively low. (3) Analyzing from the scale of map, the semantic consistency of the generalization results for the two kinds of data is close to 1, while, in the aspect of semantic completeness, the land type deletion situation of the raster data generalization result is more serious

Synthesis of (+)-Cortistatin A

Steroids have historically elicited attention from the chemical sciences owing to their utility in living systems, as well as their intrinsic and diverse beauty.1 The cortistatin family (Figure 1, 1-7 and others),2 a collection of unusual, marine 9-(10,19)-abeo-androstane steroids, is certainly no exception; aside from challenging stereochemistry and an odd bricolage of functional groups, the salient feature of these sponge metabolites is, inescapably, their biological activity. Cortistatin A, the most potent member of the small family, inhibits the proliferation of human umbilical vein endothelial cells (HUVECs, IC50) 1.8 nM), evidently with no general toxicity toward either healthy or cancerous cell lines (IC50(testing cells)/IC50(HUVECs) g 3300).2a From initial pharmacological studies, binding appears to occur reversibly, but to an unknown target, inhibiting the phosphorylation of an unidentified 110 kDa protein, and implying a pathway that may be unique to know

A Multitarget Land Use Change Simulation Model Based on Cellular Automata and Its Application

Based on the analysis of the existing land use change simulation model, combined with macroland use change driving factors and microlocal land use competition, and through the application of Python language integrated technical approaches such as CA, GIS, AHP, and Markov, a multitarget land use change simulation model based on cellular automata(CA) is established. This model was applied to conduct scenario simulation of land use/cover change of the Jinzhou New District, based on 1:10000 map scale land use, planning, topography, statistics, and other data collected in the year of 1988, 2003, and 2012. The simulation results indicate the following: (1) this model can simulate the mutual transformation of multiple land use types in a relatively satisfactory way; it takes land use system as a whole and simultaneously takes the land use demand in the macrolevel and the land use suitability in the local scale into account; and (2) the simulation accuracy of the model reaches 72%, presenting higher creditability. The model is capable of providing auxiliary decision-making support for coastal regions with the analysis of the land use change driving mechanism, prediction of land use change tendencies, and establishment of land resource sustainable utilization policies

Delisheng, a Chinese medicinal compound, exerts anti-proliferative and pro-apoptotic effects on HepG2 cells through extrinsic and intrinsic pathways

The anti-proliferative, cytotoxic and apoptogenic activities of delisheng, a Chinese medicinal compound, has been investigated. In this study, the hepatocarcinoma cell line (HepG2) and the liver cell line (L-02) were exposed to delisheng (6.25, 50 and 100 μl/ml). Delisheng suppressed the proliferation and viability of normal liver L-02 cells slightly, but strongly inhibited the proliferation and viability of hepatocarcinoma HepG2 cells. The flow cytometric analysis of HepG2 cells demonstrated that delisheng primarily arrested the HepG2 cells at the G1 phase of the cell cycle. Annexin V-FITC/PI staining corroborates the apoptogenic nature of delisheng on HepG2 cells. The anti-proliferative and pro-apoptotic effect of delisheng in HepG2 cells was associated with changes in the Bcl-2/Bax ratio and the induction of caspase-mediated apoptosis. Upregulation of DR5 expression was observed in HepG2 cells after treatment with delisheng. The findings from the present study suggest that delisheng has selective cytotoxic activities against HepG2 cells. Delisheng triggered time- and dose-dependent apoptosis in HepG2 cells by activating the mitochondria-mediated and death receptor-mediated apoptotic pathways