TM2D: Bimodality Driven 3D Dance Generation via Music-Text Integration

We propose a novel task for generating 3D dance movements that simultaneously incorporate both text and music modalities. Unlike existing works that generate dance movements using a single modality such as music, our goal is to produce richer dance movements guided by the instructive information provided by the text. However, the lack of paired motion data with both music and text modalities limits the ability to generate dance movements that integrate both. To alleviate this challenge, we propose to utilize a 3D human motion VQ-VAE to project the motions of the two datasets into a latent space consisting of quantized vectors, which effectively mix the motion tokens from the two datasets with different distributions for training. Additionally, we propose a cross-modal transformer to integrate text instructions into motion generation architecture for generating 3D dance movements without degrading the performance of music-conditioned dance generation. To better evaluate the quality of the generated motion, we introduce two novel metrics, namely Motion Prediction Distance (MPD) and Freezing Score, to measure the coherence and freezing percentage of the generated motion. Extensive experiments show that our approach can generate realistic and coherent dance movements conditioned on both text and music while maintaining comparable performance with the two single modalities. Code will be available at: https://garfield-kh.github.io/TM2D/

Action2Motion: Conditioned Generation of 3D Human Motions

Action recognition is a relatively established task, where givenan input sequence of human motion, the goal is to predict its ac-tion category. This paper, on the other hand, considers a relativelynew problem, which could be thought of as an inverse of actionrecognition: given a prescribed action type, we aim to generateplausible human motion sequences in 3D. Importantly, the set ofgenerated motions are expected to maintain itsdiversityto be ableto explore the entire action-conditioned motion space; meanwhile,each sampled sequence faithfully resembles anaturalhuman bodyarticulation dynamics. Motivated by these objectives, we followthe physics law of human kinematics by adopting the Lie Algebratheory to represent thenaturalhuman motions; we also propose atemporal Variational Auto-Encoder (VAE) that encourages adiversesampling of the motion space. A new 3D human motion dataset, HumanAct12, is also constructed. Empirical experiments overthree distinct human motion datasets (including ours) demonstratethe effectiveness of our approach.Comment: 13 pages, ACM MultiMedia 202

A Clinical Analysis of Risk Factors for Interstitial Lung Disease in Patients with Idiopathic Inflammatory Myopathy

Interstitial lung disease (ILD) is a common and severe complication of idiopathic inflammatory myopathies (IIM). The aim of our study was to identify risk factors for ILD by evaluating both clinical and biochemical features in IIM patients with or without ILD. From January 2008 to December 2011, medical records of 134 IIM patients in our rheumatology unit were reviewed. The patients were divided into ILD group (83 patients) and non-ILD group (51 patients). The clinical features and laboratory findings were compared. The univariable analyses indicated that arthritis/arthralgia (54.2% versus 17.6%, P<0.05), Mechanic’s hand (16.9% versus 2.0%, P<0.05), Raynaud’s phenomenon (36.1% versus 2.0%, P<0.05), heliotrope rash (44.6% versus 19.6%, P<0.05), fever (43.4% versus 21.6%, P<0.05), elevated ESR (60.2% versus 35.3%, P<0.05), elevated CRP (55.4% versus 31.4%, P<0.05), or anti-Jo-1 antibody (20.5% versus 5.9%, P<0.05) were risk factors for developing ILD in IIM. Multivariable unconditional logistic regression analysis that showed arthritis/arthralgia (OR 7.1, 95% CI 2.8–18.1), Raynaud’s phenomenon (OR 29.1, 95% CI 3.6–233.7), and amyopathic dermatomyositis (ADM) (OR 20.2, 95% CI 2.4–171.2) were the independent risk factors for developing ILD in IIM

QCD Sum Rules for The Double Ratio (fBs/fBd)/(fDs/fDd)(f_{B_s}/f_{B_d}) /(f_{D_s}/f_{D_d}) in HQET

The double ratio $(f_{B_s}/f_{B_d})/(f_{D_s}/f_{D_d})$ is calculated by QCD sum rules in heavy quark effective theory (HQET), both numerically and analytically. Our expression for the double ratio shows explicitly the dependence on the light quark masses, the heavy quark symmetry breaking and the vacuum condensates. The numerical result favors the double ratio to be a little greater than 1.Comment: 11 pages, latex file with one figure not included, to appear in Phys.Lett.

Incidence of adverse cardiovascular events associated with immune checkpoint inhibitors and risk factors for left ventricular dysfunction: A single-center prospective clinical study

BackgroundThe incidence of immune checkpoint inhibitors (ICI)-related adverse cardiovascular events (ACEs) may be underestimated, and there are few reports on the incidence and risk factors of ICI-induced left ventricular dysfunction (LVD).ObjectivesThis study aimed to investigate the incidence of ACEs caused by ICI, in particular to analyze the incidence and risk factors of LV systolic and diastolic dysfunction.Materials and methodsA prospective clinical study was performed on patients who received ICI in our hospital from November 2020 to October 2021. They received regular cardiovascular examinations, including echocardiography, ECG, cTnT, and NT-proBNP, etc. The incidence of various ACEs was counted, and the risk factors of LVD were analyzed.ResultsA total of 106 cancer patients treated with ICI were recruited. During the follow-up, 41 patients (38.68%) developed various ECG abnormalities, 39 patients (36.79%) developed LVDD, 9 patients (8.49%) developed CTRCD, and 2 patients (1.89%) developed new pericardial effusion. The patients with elevated cTnT, CK-MB, and NT-proBNP were 10 (9.43%), 8 (7.55%), and 8 (7.5%), respectively. Thirteen of the 52 patients with LVD had hypertension, while 4 of the 54 patients without LVD had hypertension (OR = 4.17, 95% CI: 1.26–13.78; P = 0.019). The baseline LVEF and LVFS of patients with LVD were 61.54 ± 4.15% and 33.78 ± 2.73%, while those of the control group were 64.16 ± 3.68% and 34.95 ± 2.84, respectively (P = 0.003 and P = 0.048). Compared with patients without LVD, patients with LVD had lower e’ (6.99 ± 1.33 cm/s vs. 7.64 ± 1.39 cm/s, P = 0.029) and higher E to e’ ratio (11.89 ± 3.15 cm/s vs. 10.43 ± 2.52, P = 0.024). Multiple regression analysis showed that a history of hypertension (HR = 26.52, 95% CI: 2.479–283.667, P = 0.007) and lower baseline e’ (HR = 0.04, 95% CI: 0.003–0.709, P = 0.028) were risk factors for developing LVD.ConclusionPatients treated with ICI may develop multiple ACEs, including acute myocarditis, pericarditis, ECG abnormalities, and elevated cardiac biomarkers. ICI may lead to a high incidence of LVD, and echocardiography is helpful for early detection of LVD. Patients with hypertension or poor LV systolic or diastolic function at baseline were predictors of LVD after ICI treatment

SDSS J013127.34−-032100.1: A newly discovered radio-loud quasar at z=5.18z=5.18 with extremely high luminosity

Only very few z>5 quasars discovered to date are radio-loud, with a radio-to-optical flux ratio (radio-loudness parameter) higher than 10. Here we report the discovery of an optically luminous radio-loud quasar, SDSS J013127.34-032100.1 (J0131-0321 in short), at z=5.18+-0.01 using the Lijiang 2.4m and Magellan telescopes. J0131-0321 has a spectral energy distribution consistent with that of radio-loud quasars. With an i-band magnitude of 18.47 and radio flux density of 33 mJy, its radio-loudness parameter is ~100. The optical and near-infrared spectra taken by Magellan enable us to estimate its bolometric luminosity to be L_bol ~ 1.1E48 erg/s, approximately 4.5 times greater than that of the most distant quasar known to date. The black hole mass of J0131-0321 is estimated to be 2.7E9 solar masses, with an uncertainty up to 0.4 dex. Detailed physical properties of this high-redshift, radio-loud, potentially super-Eddington quasar can be probed in the future with more dedicated and intensive follow-up observations using multi-wavelength facilities.Comment: 5 pages, 3 figures, accepted to ApJ

The possible roles of hyperpolarization-activated cyclic nucleotide channels in regulating pacemaker activity in colonic interstitial cells of Cajal

BACKGROUND: Hyperpolarization-activated cyclic nucleotide (HCN) channels are pacemaker channels that regulate heart rate and neuronal rhythm in spontaneously active cardiac and neuronal cells. Interstitial cells of Cajal (ICCs) are also spontaneously active pacemaker cells in the gastrointestinal tract. Here, we investigated the existence of HCN channel and its role on pacemaker activity in colonic ICCs. METHODS: We performed whole-cell patch clamp, RT-PCR, and Ca(2+)-imaging in cultured ICCs from mouse mid colon. RESULTS: SQ-22536 and dideoxyadenosine (adenylate cyclase inhibitors) decreased the frequency of pacemaker potentials, whereas both rolipram (cAMP-specific phosphodiesterase inhibitor) and cell-permeable 8-bromo-cAMP increased the frequency of pacemaker potentials. CsCl, ZD7288, zatebradine, clonidine (HCN channel blockers), and genistein (a tyrosine kinase inhibitor) suppressed the pacemaker activity. RT-PCR revealed expression of HCN1 and HCN3 channels in c-kit and Ano1 positive colonic ICCs. In recordings of spontaneous intracellular Ca(2+) [Ca(2+)](i) oscillations, rolipram and 8-bromo-cAMP increased [Ca(2+)](i) oscillations, whereas SQ-22536, CsCl, ZD7288, and genistein decreased [Ca(2+)](i) oscillations. CONCLUSIONS: HCN channels in colonic ICCs are tonically activated by basal cAMP production and participate in regulation of pacemaking activity

Lectotypication of Acroporium hyalinum (Reinw. ex Schwägr.) Mitt. (Hypnales: Sematophyllaceae).

Acroporium hyalinum (Reinw. ex Schwägr.) Mitt., an older name for Acroporium stramineum (Reinw. & Hornsch.) M.Fleisch., is applied here in accordance with the principle of nomenclatural priority. Acroporium hyalinum is broadly circumscribed by its erect-spreading, ovate-lanceolate leaves with short acuminate tips. Its infra-speci¬c delimitation, however, has not been clearly resolved. Based on careful examination of nearly 200 specimens, including 35 types associated with A. hyalinum and its synonyms, all the three varieties proposed by Tan (1994) are accepted here as Acroporium hyalinum (Reinw. ex Schwägr.) Mitt. var. hyalinum,A. hyalinum var. hamulatum (M.Fleisch.) M.S.Chua & B.C.Ho, and A. hyalinum var. turgidum (M.Fleisch.) M.S.Chua & B.C.Ho, the latter two names being new combinations. Descriptions and an identi¬cation key of these three varieties are provided, along with taxonomic notes and illustrations. Lectotypi¬cation of Hypnum hyalinum Reinw. & Hornsch. is proposed