Etch Rate and Dimensional Accuracy of Machinable Glass Ceramics in Chemical Etching

Machinable glass ceramic (MGC) is well known in the micro-electromechanical system and semiconductor industry. Chemical etching is used in this experiment to study the performance of MGC. The etching rate of MGC and its accuracy by indentation method is studied. The categoric parameter applied here is the type of chemical etchant used: hydrochloric (HCl), hydrophosphoric (H3PO4) and hydrobromic (HBr) acids; and, numerical parameters are etching temperature and etching solution. The experimental investigation that was carried out is governed by design of experiment (DoE)

Application of design of experiment for modelling of etching of ceramics

These instructions give you guidelines for preparing papers for EnCon 2008. Use this document as a template if you are using Microsoft Word 6.0 or later. Otherwise, use this document as an instruction set. Define all symbols used in the abstract. Do not cite references in the abstract. Do not delete the blank line immediately above the abstract; it sets the footnote at the bottom of this column. The abstract text should be formatted using 9 point Times (or Times Roman, or Times New Roman). The abstract follows the addresses and should give readers concise information about the content of the article and indicate the main results obtained and conclusions drawn. It should be self-contained with no reference to figures, tables, equations or bibliographic references and should not normally exceed 200 words

Prediction of Etching Rate of Alumino-Silicate Glass by RSM and ANN

920-924In this study, response surface methodology (RSM) andartificial neural network (ANN) were applied to predict material removal rate in chemical etching process of alumino-silicate glass (SiO2 57/Al2O3 36/CaO/MgO/BaO). 2k Factorial design was performed to evaluate linearity condition among process parameters. Analysis of variance (ANOVA) was performed and quadratic model was found most significant for data values of process parameters. New models were able to predict etching rate of alumino-silicate glass, with a great confidence. Input parameters analyzed were temperature, etching period and type of setup with and without condensation

Relationship between Diet Quality and Maternal Stool Microbiota in the MUMS Australian Pregnancy Cohort

Dietary intake during pregnancy may influence the antenatal microbiome, which is proposed to impact maternal and infant health during the pregnancy and beyond. The aim of this sub-study was to examine associations between dietary intake and microbiota diversity during pregnancy using whole metagenomic sequencing and examine associations in low-risk versus high-risk pregnancies, as well as complicated versus uncomplicated pregnancies. Pregnancy data were analysed from women participating in the MUMS cohort study in Sydney, Australia (women followed from trimester 1 of pregnancy to 1-year postpartum), who had dietary intake data at either trimester 1 or 3, assessed using the Australian Eating Survey, and a matched stool sample (n = 86). Correlations of microbial alpha diversity with dietary intake data were determined using the repeated-measures correlation, rmcorr, in R. In the combined cohort, no associations were found between diet quality or diet composition and microbial alpha diversity or beta diversity. However, trends in our analysis suggested that dietary intake of specific macro- and micronutrients may influence microbial diversity differently, depending on particular pregnancy conditions. Our findings suggest that dietary intake during pregnancy may have a variable influence on the maternal microbiota, unique to the individual maternal pregnancy phenotype. More research is needed to disentangle these associations

Mechanistic insights into the pathogenesis of microtubule‐targeting agent‐induced peripheral neuropathy from pharmacogenetic and functional studies

Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity that affects 30%-40% of patients undergoing cancer treatment. Although multiple mechanisms of chemotherapy-induced neurotoxicity have been described in preclinical models, these have not been translated into widely effective strategies for the prevention or treatment of CIPN. Predictive biomarkers to inform therapeutic approaches are also lacking. Recent studies have examined genetic risk factors associated with CIPN susceptibility. This review provides an overview of the clinical and pathologic features of CIPN and summarizes efforts to identify target pathways through genetic and functional studies. Structurally and mechanistically diverse chemotherapeutics are associated with CIPN; however, the current review is focused on microtubule-targeting agents since these are the focus of most pharmacogenetic association and functional studies of CIPN. Genome-wide pharmacogenetic association studies are useful tools to identify not only causative genes and genetic variants but also genetic networks implicated in drug response or toxicity and have been increasingly applied to investigations of CIPN. Induced pluripotent stem cell-derived models of human sensory neurons are especially useful to understand the mechanistic significance of genomic findings. Combined genetic and functional genomic efforts to understand CIPN hold great promise for developing therapeutic approaches for its prevention and treatment.Fil: Chua, Katherina C.. University of California; Estados UnidosFil: El Haj, Nura. University of California; Estados UnidosFil: Priotti, Josefina. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Kroetz, Deanna L.. University of California; Estados Unido

Probiotication of Punica granatum (pomegranate) juice by lactobacillus plantarum

Fruit juice enriched with probiotics is increasingly accepted nowadays, mainly due to its health benefit for digestive system. In particular, probioticated fruit juice is the good choice for those who are having lactose intolerant problem from milk based drinks. In the present study, the whole fruit of Punica granatum (pomegranate) has been probioticated with Lactobacillus plantarum at different fermentation temperatures (22ºC, 30ºC and 35ºC). The growth rate of L. plantarum has been monitored based on the optical density and acidity of the broth culture at 24 hours of time interval for 72 hours. The bacterial growth in the pomegranate juice was predicted by measuring absorbance at 600 nm spectrophotometrically and pH value by a pH meter. There was an increasing trend in the bacterial growth of L. plantarumincubated at 35ºC compared to other temperatures at 22ºC and 30ºC. The results also indicated there was no significant changes on pH during the fermentation as the bacterial strain was in adaptation process with the new medium and conditions. Meanwhile, the antioxidant assay showed that probiotication of pomegranate juice by L. plantarum significantly increased the radical scavenging activity. The pomegranate juice was shown to be a suitable substrate for L. plantarum cultivation at 35ºC

Effects of agitation speed and kinetic studies on probiotication of pomegranate juice with Lactobacillus casei

The issues of lactose intolerance and vegetarianism have encouraged the introduction of non-dairy fermented food into the market. Therefore, this study aims to evaluate the effect of agitation speed on the bioactive compounds and functional characteristics of probioticated pomegranate juice. Pomegranate juice was fermented with Lactobacillus casei at different agitation speeds ranging from 0 (microaerophilic) to 150 rpm at 37 °C. The functional properties of probioticated pomegranate juice were evaluated in terms of growth (biomass), lactic acid production, antioxidant activity, total phenolic content, and key metabolites using LC-MS/MS. The growth kinetics of fermentation was monitored at the optimal condition using one factor at a time method. High cell growth (3.58 × 1010 cfu/mL or 7.9 gL-1) was observed for L. casei probioticated pomegranate juice agitated at 0 rpm. The findings of this study reveal the potential of pomegranate juice as a medium for L. casei cultivation without nutrient supplementation. The improvement of antioxidant activity in the probioticated juice could be due to the increment of quercetin-3-glucoside. Therefore, L. casei grew well in pomegranate juice with a high cell viability and antioxidant activity at a non-agitated condition. Probioticated pomegranate juice is a potentially functional drink

The MothersBabies Study, an Australian Prospective Cohort Study Analyzing the Microbiome in the Preconception and Perinatal Period to Determine Risk of Adverse Pregnancy, Postpartum, and Child-Related Health Outcomes: Study Protocol

The microbiome has emerged as a key determinant of human health and reproduction, with recent evidence suggesting a dysbiotic microbiome is implicated in adverse perinatal health outcomes. The existing research has been limited by the sample collection and timing, cohort design, sample design, and lack of data on the preconception microbiome. This prospective, longitudinal cohort study will recruit 2000 Australian women, in order to fully explore the role of the microbiome in the development of adverse perinatal outcomes. Participants are enrolled for a maximum of 7 years, from 1 year preconception, through to 5 years postpartum. Assessment occurs every three months until pregnancy occurs, then during Trimester 1 (5 + 0–12 + 6 weeks gestation), Trimester 2 (20 + 0–24 + 6 weeks gestation), Trimester 3 (32 + 0–36 + 6 weeks gestation), and postpartum at 1 week, 2 months, 6 months, and then annually from 1 to 5 years. At each assessment, maternal participants self-collect oral, skin, vaginal, urine, and stool samples. Oral, skin, urine, and stool samples will be collected from children. Blood samples will be obtained from maternal participants who can access a study collection center. The measurements taken will include anthropometric, blood pressure, heart rate, and serum hormonal and metabolic parameters. Validated self-report questionnaires will be administered to assess diet, physical activity, mental health, and child developmental milestones. Medications, medical, surgical, obstetric history, the impact of COVID-19, living environments, and pregnancy and child health outcomes will be recorded. Multiomic bioinformatic and statistical analyses will assess the association between participants who developed high-risk and low-risk pregnancies, adverse postnatal conditions, and/or childhood disease, and their microbiome for the different sample types

Performance evaluation of a waste-heat driven adsorption system for automotive air-conditioning: Part II - Performance optimization under different real driving conditions

[EN] In this part, Part 11, of a two-part study, the validated model of part I is integrated into a general vehicle model in order to predict the performance of the system under real driving conditions. The overall model takes into account all the system components to simulate the dynamic performance of the entire system and predict the cabin temperature at the available waste heat. The system was implemented in a Fiat Grande Punto vehicle and the experimental tests were performed at the Centro Ricerche Fiat (CRF), Italy laboratories. Different design configurations were investigated to explore further improvements of the performance. Results showed that the model was able to well predict the transient performance of the system under different start-up and ambient conditions as well as the normal operating conditions. Using two radiators instead of one radiator increases the cooling capacity by 7.0% and decreases the cabin temperature by 9.1%. At the warming up period, the adsorption system faces serious difficulties to start producing the required cooling. Possible strategies to avoid this problem were studied and compared. In general, it has been proved that the amount of engine waste heat available is sufficient to produce enough cooling to keep reasonably comfortable temperatures in the cabin. (C) 2016 Elsevier Ltd. All rights reserved.This work has been partially supported by the Thermally Operated Mobile Air Conditioning Systems (TOPMACS). The authors are very grateful to the Energy Research Center of Netherlands (ECN) for their support with the experimental work.This work has been partially supported by the Thermally Operated Mobile Air Conditioning Systems (TOPMACS). The authors are very grateful to the Energy Research Center of Netherlands (ECN) for their support in the experimental work.Verde Trindade, M.; Harby Mohamed Abd Alaal, K.; De Boer, R.; Corberán, JM. (2016). Performance evaluation of a waste-heat driven adsorption system for automotive air-conditioning: Part II - Performance optimization under different real driving conditions. Energy. 115:996-1009. doi:10.1016/j.energy.2016.09.086S996100911

Optical properties of zinc borotellurite glass system doped with erbium and erbium nanoparticles for photonic applications

Comparative analysis on optical properties between two glass series (a—ordinary glass, b—glass with nanoparticles) have been estimated. The two glass series (a—ordinary glass, b—glass with nanoparticles) with compositions {[(TeO2)0.70 (B2O3)0.30]0.70 (ZnO)0.30}1−y (Er2O3/Er2O3 nanoparticles)y; y = 0.005, 0.01, 0.02, 0.03, 0.04, 0.05 mol% were successfully prepared by using melt-quenching method. The TEM, EDX and XRD have been used to confirm the existence of nanoparticles and all elements in the glass system. The density of b—glass with nanoparticles are found greater than a—ordinary glass. The optical properties of the glass series were characterized by using Ellipsometer and UV–Vis spectrophotometer. There is a linear increasing trend in refractive index of the glass series along with concentration of erbium and erbium nanoparticles oxide. The refractive index of b—glass with nanoparticles is greater than a—ordinary glass. Moreover, the absorption peaks of a—ordinary glass are more intense than b—glass with nanoparticles. The glass with nanoparticles will offer a potential materials for nanophotonic devices