Marriott International: Deploying AI across hotel brands in Singapore

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Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface

Zyxin regulates mouse embryonic stem cell differentiation by integrating mechanical cues through actin stress fibres and focal adhesions and biochemical cues through YAP signalling

Zyxin Is involved in fibroblast rigidity sensing and durotaxis

Focal adhesions (FAs) are specialized structures that enable cells to sense their extracellular matrix rigidity and transmit these signals to the interior of the cells, bringing about actin cytoskeleton reorganization, FA maturation, and cell migration. It is known that cells migrate towards regions of higher substrate rigidity, a phenomenon known as durotaxis. However, the underlying molecular mechanism of durotaxis and how different proteins in the FA are involved remain unclear. Zyxin is a component of the FA that has been implicated in connecting the actin cytoskeleton to the FA. We have found that knocking down zyxin impaired NIH3T3 fibroblast’s ability to sense and respond to changes in extracellular matrix in terms of their FA sizes, cell traction stress magnitudes and F-actin organization. Cell migration speed of zyxin knockdown fibroblasts was also independent of the underlying substrate rigidity, unlike wild type fibroblasts which migrated fastest at an intermediate substrate rigidity of 14 kPa. Wild type fibroblasts exhibited durotaxis by migrating toward regions of increasing substrate rigidity on polyacrylamide gels with substrate rigidity gradient, while zyxin knockdown fibroblasts did not exhibit durotaxis. Therefore, we propose zyxin as an essential protein that is required for rigidity sensing and durotaxis through modulating FA sizes, cell traction stress and F-actin organization

Proceedings of International Technical Postgraduate Conference 2022

This conference proceedings contains articles on the various research ideas of the academic &amp; research communities presented at the International Technical Postgraduate Conference 2022 (TECH POST 2022) that was held at Universiti Malaya, Kuala Lumpur, Malaysia on 24-25 September 2022. TECH POST 2022 was organized by the Faculty of Engineering, Universiti Malaya. The theme of the conference is “Embracing Innovative Engineering Technologies Towards a Sustainable Future”.  TECH POST 2022 conference is intended to foster the dissemination of state-of-the-art research from five main disciplines of Engineering: Electrical Engineering, Biomedical Engineering, Civil Engineering, Mechanical Engineering, and Chemical Engineering. The objectives of TECH POST 2022 are to bring together innovative researchers from all engineering disciplines to a common forum, promote R&amp;D activities in Engineering, and promote the dissemination of scientific knowledge and research know-how between researchers, engineers, and students. Conference Title: International Technical Postgraduate Conference 2022Conference Acronym: TECH POST 2022Conference Date: 24-25 September 2022Conference Location: Faculty of Engineering, Universiti Malaya, Kuala Lumpur Malaysia (Hybrid Mode)Conference Organizers: Faculty of Engineering, Universiti Malaya, Kuala Lumpur, Malaysia