The Light Regime Effect on Triacylglycerol Accumulation of Isochrysis zhangjiangensis

Stress state of microalgal cells is caused under unfavorable conditions such as disordered light regime and depleted nitrogen. The stress state can impair photosynthetic efficiency, inhibit cell growth and result in the accumulation of triacylglycerol (TAG) from protective mechanisms. Continuous light or nitrogen starvation was applied on microalgae and performed effectively on inducing TAG production. To evaluate the light regime effect on inducing TAG production, the effect of different light regimes on nitrogen-starved Isochrysis zhangjiangensis was investigated in this work. The continuous light and nitrogen starvation elevated TAG content of biomass by 73% and 193%, respectively. Furthermore, the TAG accumulation of I. zhangjiangensis cell under nitrogen starvation decreased under aggravated stress from continuous illumination. Our results demonstrated that culturing the cells with 14L: 10D light regime under nitrogen starvation is the optimal mode to achieve maximal accumulation of TAG. A recovery in light regime was necessary for I. zhangjiangensis cultivation

thelightregimeeffectontriacylglycerolaccumulationofisochrysiszhangjiangensis

Stress state of microalgal cells is caused under unfavorable conditions such as disordered light regime and depleted nitrogen.The stress state can impair photosynthetic efficiency,inhibit cell growth and result in the accumulation of triacylglycerol(TAG)from protective mechanisms.Continuous light or nitrogen starvation was applied on microalgae and performed effectively on inducing TAG production.To evaluate the light regime effect on inducing TAG production,the effect of different light regimes on nitrogen-starved Isochrysis zhangjiangensis was investigated in this work.The continuous light and nitrogen starvation elevated TAG content of biomass by 73%and 193%,respectively.Furthermore,the TAG accumulation of I.zhangjiangensis cell under nitrogen starvation decreased under aggravated stress from continuous illumination.Our results demonstrated that culturing the cells with 14L:10D light regime under nitrogen starvation is the optimal mode to achieve maximal accumulation of TAG.A recovery in light regime was necessary for I.zhangjiangensis cultivation

thelightregimeeffectontriacylglycerolaccumulationofisochrysiszhangjiangensis

Stress state of microalgal cells is caused under unfavorable conditions such as disordered light regime and depleted nitrogen.The stress state can impair photosynthetic efficiency,inhibit cell growth and result in the accumulation of triacylglycerol(TAG)from protective mechanisms.Continuous light or nitrogen starvation was applied on microalgae and performed effectively on inducing TAG production.To evaluate the light regime effect on inducing TAG production,the effect of different light regimes on nitrogen-starved Isochrysis zhangjiangensis was investigated in this work.The continuous light and nitrogen starvation elevated TAG content of biomass by 73%and 193%,respectively.Furthermore,the TAG accumulation of I.zhangjiangensis cell under nitrogen starvation decreased under aggravated stress from continuous illumination.Our results demonstrated that culturing the cells with 14L:10D light regime under nitrogen starvation is the optimal mode to achieve maximal accumulation of TAG.A recovery in light regime was necessary for I.zhangjiangensis cultivation

Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion

Vascular remodeling is a prominent feature of pulmonary hypertension. This process involves increased muscularization of already muscularized vessels as well as neo-muscularization of non-muscularized vessels. The cell-of-origin of the newly formed vascular smooth muscle cells has been a subject of intense debate in recent years. Identifying these cells may have important clinical implications since it opens the door for attempts to therapeutically target the progenitor cells and/or reverse the differentiation of their progeny. In this context, the dominant model is that these cells derive from pre-existing smooth muscle cells that are activated in response to injury. In this mini review, we present the evidence that is in favor of this model and, at the same time, highlight other studies indicating that there are alternative cellular sources of vascular smooth muscle cells in pulmonary vascular remodeling

Targeting Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension (BPD-PH): Potential Role of the FGF Signaling Pathway in the Development of the Pulmonary Vascular System

More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH), leading to a significant increase in total morbidity and mortality. Until today, there is no curative therapy for both BPD and BPD-PH available. It has become increasingly evident that growth factors are playing a central role in normal and pathologic development of the pulmonary vasculature. Thus, this review aims to summarize the recent evidence in our understanding of BPD-PH from a basic scientific point of view, focusing on the potential role of Fibroblast Growth Factor (FGF)/FGF10 signaling pathway contributing to disease development, progression and resolution

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

International audienc