Exploring Intention Behavior Gap by E-Learning Discourses

IS study emphasizes behavioral intention with an assumption that users increase system use when they have higher intentions. But this assumption is challenged by emerging studies. Taking an e-learning as an example, this study investigates the gap between intention and e-learning behaviors. Specifically, our investigation applied a discourse analysis, in addition to time expand and login frequency, for measuring e-learning behaviors. By analyzing 833 discourses posted by 14 users in an online course, our preliminary findings suggested that intention was insignificant to discourses and login frequency. However, the correlation between intention and time expand is negative significant. Our findings also presented that users who spent more time on e-learning had lower intention but used the platform more frequently. These users devoted equivalent effort on making task-oriented discourse, but they expressed more social and procedural discourses. These findings provided preliminary evidences on and an explanation to intention-behavior gap

A Temporal Usage Pattern-based Tag Recommendation Approach

While social tagging can benefit Internet users managing their resources, it suffers the problems such as diverse and/or unchecked vocabulary and unwillingness to tag. Use of freely new tags and/or reuse of frequent tags have degraded coherence of corresponding resources of each tag that further frustrates people in retrieving information due to cognitive dissonance. Tag recommender systems can recommend users the most relevant tags to the resource they intend to annotate, and drastically transfer the tagging process from generation to recognition to reduce user’s cognitive effort and time. Prior research on tag recommendation has addressed the time-dependence issues of tags by applying a time decaying measure to determine the recurrence probability of a tag according to its recency instead of its usage pattern. In response, this study intends to propose the temporal usage pattern-based tag recommendation technique to consider the usage patterns and temporal characteristic of tags for making recommendations

A Temporal Frequent Itemset-Based Clustering Approach For Discovering Event Episodes From News Sequence

When performing environmental scanning, organizations typically deal with a numerous of events and topics about their core business, relevant technique standards, competitors, and market, where each event or topic to monitor or track generally is associated with many news documents. To reduce information overload and information fatigues when monitoring or tracking such events, it is essential to develop an effective event episode discovery mechanism for organizing all news documents pertaining to an event of interest. In this study, we propose the time-adjoining frequent itemset-based event-episode discovery (TAFIED) technique. Based on the frequent itemset-based hierarchical clustering (FIHC) approach, our proposed TAFIED further considers the temporal characteristic of news articles, including the burst, novelty, and temporal proximity of features in an event episode, when discovering event episodes from the sequence of news articles pertaining to a specific event. Using the traditional feature-based HAC, HAC with a time-decaying function (HAC+TD), and FIHC techniques as performance benchmarks, our empirical evaluation results suggest that the proposed TAFIED technique outperforms all evaluation benchmarks in cluster recall and cluster precision

A novel randomly textured phosphor structure for highly efficient white light-emitting diodes

We have successfully demonstrated the enhanced luminous flux and lumen efficiency in white light-emitting diodes by the randomly textured phosphor structure. The textured phosphor structure was fabricated by a simple imprinting technique, which does not need an expensive dry-etching machine or a complex patterned definition. The textured phosphor structure increases luminous flux by 5.4% and 2.5% at a driving current of 120 mA, compared with the flat phosphor and half-spherical lens structures, respectively. The increment was due to the scattering of textured surface and also the phosphor particles, leading to the enhancement of utilization efficiency of blue light. Furthermore, the textured phosphor structure has a larger view angle at the full width at half maximum (87°) than the reference LEDs

Prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan

<p>Abstract</p> <p>Background</p> <p>In Taiwan, a distinct ethnic group variation in incidence and mortality rates has been suggested for most carcinomas. Our aim is to identify the role of prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan.</p> <p>Methods</p> <p>Taiwan Cancer Registry records of 9039 subjects diagnosed with oral and pharyngeal carcinoma were analyzed. The population was divided into three ethnic groups by residence, which were Taiwanese aborigines, Hakka and Hokkien communities. Five-year survival rates were estimated by Kaplan-Meier methods. Ethnic curves differed significantly by log-rank test; therefore separate models for Taiwanese aborigines, Hakka and Hokkien were carried out. The Cox multivariate proportional hazards model was used to examine the role of prognostic factors on ethnic survival.</p> <p>Results</p> <p>The five-year survival rates of oral and pharyngeal carcinoma were significantly poorer for Hokkien community (53.9%) and Taiwanese aborigines community (58.1%) compared with Hakka community (60.5%). The adjusted hazard ratio of Taiwanese aborigines versus Hakka was 1.07 (95%CI, 0.86–1.33) for oral and pharyngeal carcinoma mortality, and 1.16 (95%CI, 1.01–1.33) for Hokkien versus Hakka. Males had significantly poor prognosis than females. Subjects with tongue and/or mouth carcinoma presented the worst prognosis, whereas lip carcinoma had the best prognosis. Subjects with verrucous carcinoma had better survival than squamous cell carcinoma. Prognosis was the worst in elderly subjects, and subjects who underwent surgery had the highest survival rate.</p> <p>Conclusion</p> <p>Our study presented that predictive variables in oral and pharyngeal carcinoma survival have been: ethnic groups, period of diagnosis, gender, diagnostic age, anatomic site, morphologic type, and therapy.</p

X-linked hyper-IgM syndrome with CD40LG mutation: Two case reports and literature review in Taiwanese patients

Hyper-IgM syndrome (HIGM) is a rare primary immunodeficiency disorder characterized by elevated or normal serum IgM and decreased IgG, IgA, and IgE due to defective immunoglobulin class switching. X-linked HIGM (XHIGM, HIGM1) is the most frequent type, is caused by mutations in the CD40 ligand gene, and is regarded as a combined T and B immunodeficiency. We report an 18-year-old male who was diagnosed initially with hypogammaglobulinemia in infancy, but developed repeated pneumonia, sepsis, cellulitis, perianal abscess, pericarditis, and bronchiectasis despite regular intravenous immunoglobulin replacement therapy. The patient died at age 18 years due to pneumonia and tension pneumothorax. Mutation analysis revealed CD40L gene mutation within Exon 5 at nucleotide position 476 (cDNA 476G > A). This nonsense mutation predicted a tryptophan codon (TGG) change to a stop codon (TGA) at position 140 (W140X), preventing CD40L protein expression. Sequence analysis in the family confirmed a de novo mutation. The second case of 6-month-old male infant presented as Pneumocystis jiroveci pneumonia and acute respiratory distress syndrome. Gene analysis of the CD40L gene revealed G to C substitution in Intron 4 (c.409 + 5G > C) and mother was a carrier. Hematopoietic stem cell transplantation, the only cure for XHIGM, was arranged in the second case

Timosaponin AIII Suppresses Hepatocyte Growth Factor-Induced Invasive Activity through Sustained ERK Activation in Breast Cancer MDA-MB-231 Cells

Background. The aim of this study was to investigate the mechanisms by which Timosaponin AIII (TAIII) is able to inhibit HGF-induced invasion activity in the triple negative breast cancer cell line MDA-MB-231. Methods. After pretreatment with different concentrations (10−6~10−8 M) of TAIII, the cells were treated with hepatocyte growth factor (HGF, 15 ng/mL). At different time intervals after coincubation, various parameters, including the expression of c-Met, ERK, COX2, and MMP-9, which were assessed by Western blotting or by real-time PCR, were analyzed. In addition, invasive activity was also monitored. Results. HGF was found to induce c-MET activation and ERK activation, together with increased COX2 protein expression; these changes were followed by a subsequent increase in invasive activity. TAIII was found to suppress HGF-induced invasive activity and COX2 gene expression in a concentration-dependent manner (10−6~10−8 M) in parallel with increases in the phosphoforms of c-Met and ERK after TAIII treatment. The mechanisms by which TAIII suppresses HGF-induced invasive activity were demonstrated to include sustained cytoplasmic and nuclear ERK activation; these led to a suppression of nuclear ATF2 activation, which was followed by downregulation of COX2 and MMP-9 transcription. Conclusion. TAIII suppresses HGF-induced invasive activity in MDA-MB-231 cells via sustained ERK activation