Effect of lycium barbarum (wolfberry) polysaccharides on preserving retinal function after partial optic nerve transection

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Human electroretinal responses to grating patterns and defocus changes by global flash multifocal electroretinogram

2014-2015 > Academic research: refereed > Publication in refereed journal201810_a bcmaVersion of RecordPublishe

Secondary degeneration after partial optic nerve injury and possible neuroprotective effects of Lycium barbarum (Wolfberry)

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Effect of Lycium Barbarum (Wolfberry) Polysaccharides on preserving retinal function after partial optic nerve transection

2013-2014 > Academic research: refereed > Publication in refereed journal201810_a bcmaVersion of RecordPublishe

Luminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patients

PURPOSE: To investigate the association of the luminance-modulation global flash multifocal electroretinogram (mfERG) and other clinical assessments of vision in subsets of subjects at high risk of developing glaucomatous damage. METHODS: Eighteen subjects (28 eyes) with asymmetric glaucoma and ocular hypertension were measured in this longitudinal study of visual field, OCT, and multifocal electroretinogram (mfERG). Five ophthalmic examinations were scheduled, once every 12 months over a 4-year period. The mfERG was assessed using a luminance-modulated global flash stimulation paradigm. The adaptive index which we have reported previously was calculated. RESULTS: There was a significant thinning of the peripapillary retinal nerve fiber layer over the course of the study for eyes with ocular hypertension, or for fellow eyes with asymmetric glaucoma which initially had an abnormal adaptive index; such eyes showed a thinning rate of -3.59 and -3.69 mum/year, respectively. However, no significant thinning was found for eyes which initially had a normal adaptive index. Two subjects were shown to have glaucomatous damage, confirmed by abnormal thinning of the retinal nerve fiber layer and visual field loss respectively at the last visit. However, these patients had shown an abnormal adaptive index in the mfERG measurement at the first visit. CONCLUSIONS: The adaptive index calculated from the measurement of luminance-modulated global flash mfERG is useful for predicting progression of signs related to glaucoma, especially in high-risk groups. The abnormal adaptive index reflects the change in fast-adaptive mechanisms in the retina and indicates the risk of developing glaucoma. © Springer-Verlag 2011.link_to_subscribed_fulltex

Temporal interactive response is resistant to cloudy ocular media in the slow double-stimulation multifocal electroretinogram

Title on author's file: Temporal interactive response is resistant to cloudy ocular media in the slow flash double-stimulation multifocal electroretinogram2012-2013 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptRGCOthersRGC: PolyU 5415/06MOthers: GU585, GU858, J-BB7P, J-BB76Publishe

Impairment of retinal adaptive circuitry in the myopic eye

2010-2011 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptRGCOthersRGC: PolyU 5415/06MOthers: J-BB7P, J-BB76Publishe

Detection of early functional changes in diabetic retina using slow double-stimulation mfERG paradigm

2011-2012 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptRGCOthersRGC: PolyU 5415/06MOthers: J-BB76Publishe

Effect of inner retinal dysfunction on slow double-stimulation multifocal electroretinogram

2011-2012 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptOthersGU585, GU858, G-YX3C, J-BB76Publishe

Effect of inner retinal dysfunction on slow double-stimulation multifocal electroretinogram

PURPOSE: This study investigated the retinal adaptive mechanism in inner retinal dysfunction using the slow double-stimulation multifocal electroretinogram (mfERG) paradigm. METHODS: Slow double-stimulation mfERG responses were recorded from 15 eyes of 15 4-month-old Mongolian gerbils in control conditions and after suppression of inner retinal responses with injections of tetrodotoxin (TTX) and N-methyl-d-aspartic acid (NMDA). The stimulation consisted of five video frames: the two initial frames with multifocal flashes were triggered by two independent m-sequences, followed by three dark video frames. The results were compared with findings in humans: 7 subjects with glaucoma and 31 age-matched normal subjects were measured using the same mfERG protocol. RESULTS: The stimulation generates two responses (M(1) and M(2)) from the two independent multifocal frames. The M(1):M(2) ratio showed a significant reduction after administration of TTX+NMDA in the animal study. This matched with the human glaucoma findings. Glaucoma subjects generally have a reduced M(1):M(2) ratio; this ratio showed a sensitivity of 86%, with a specificity of 84% for differentiating normal eyes from glaucomatous eyes. CONCLUSION: This stimulation paradigm provides a method of measuring temporal visual characteristics. The M(1):M(2) ratio acts as an indirect functional indicator of retinal adaptation, which may be abnormal in the diseased retina. Further development of this method may help to describe the functional variation in the diseased retina and to predict the occurrence of a range of retinopathies.link_to_subscribed_fulltex