Accelerator produced nuclides for use in biology and medicine

This bibliography is sorted by subject and by nuclide and also contains an author index. (MHR

THE REACTIONS OF ENERGETIC CARBON ATOMS IN METHANE OXYGEN AND PHASE DEPENDENCE RADIATION DAMAGE EFFECTS

Studies were made on the reactions of C/sup 11/ in methane containing oxygen. The nuclear reactions C/sup 12/(n,2n) and C/sup 12/(p,pn) were used to produce C/sup 11/. Concomitant radiolysis of the methane during C/sup 11/ production clearly affected product distribution. C/sup 11/-labeled ethane and propane decreased while methane, ethylene, and acetylene decreased. It was assumed that reduction by hydrogen atoms was probably occurring in the unscavenged system. The effects of oxygen and of phase are discussed. In all cases, in duplicate systems, the product distributions resulting from inducing the C/sup 12/(p,pn) reaction were the same within experimental error as those resulting from the C/sup 12/(n,2n) reaction. (P.C.H.

Carrier-free sup11sup 11C-labeled catecholamines in nuclear medicine and biochemical research

The catecholamines, dopamine, norepinephrine, and epinephrine, are synthesized and secreted by tissues such as brain, sympathetic nerve endings, and chromaffin cells. Dopamine and norepinephrine are primarily neurotransmitters while epinephrine functions mainly as a hormone. The biosynthesis of the catecholamines from tyrosine is reviewed. Abnormalities in the quantities and metabolism of these compounds are associated with many pathological conditions such as hypertension, Parkinsonism, and chromaffin tissue tumors. Rapid synthetic methods (for the preparation off)/sup 11/C-labeled catecholamines have been developed. The potential use of these labeled catecholamines as scanning agents for the adrenal glands and heart myocardium was evaluated in dogs. (CH