70 research outputs found
Anti-inflammatory effects of Lactobacillus casei BL23 producing or not a manganese-dependant catalase on DSS-induced colitis in mice
Background :Human immune cells generate large amounts of reactive oxygen species (ROS) throughout the respiratory burst that occurs during inflammation. In inflammatory bowel diseases, a sustained and abnormal activation of the immune system results in oxidative stress in the digestive tract and in a loss of intestinal homeostasis. We previously showed that the heterologous production of the Lactobacillus plantarum ATCC14431 manganese-dependant catalase (MnKat) in Lb. casei BL23 successfully enhances its survival when exposed to oxidative stress. In this study, we evaluated the preventive effects of this antioxidative Lb. casei strain in a murine model of dextran sodium sulfate (DSS)-induced moderate colitis.[br/]
Results : Either Lb. casei BL23 MnKat- or MnKat+ was administered daily to mice treated with DSS for 10 days. In contrast to control mice treated with PBS for which DSS induced bleeding diarrhea and mucosal lesions, mice treated with both Lb. casei strains presented a significant (p < 0.05) reduction of caecal and colonic inflammatory scores.[br/]
Conclusion : No contribution of MnKat to the protective effect from epithelial damage has been observed in the tested conditions. In contrast, these results confirm the high interest of Lb. casei as an anti-inflammatory probiotic strain
Dosages enzymatiques des glucides
2. ed. 43 ref. chap. 5 Mention d'édition : 2. ed.National audienc
Composition en oses neutres des bacteries attachees aux residus de digestion : incidence sur l'evaluation de la digestibilite dans le rumen
National audienc
Rapid analysis of plant cell-wall polysaccharides. Part II : quantitative analysis of plant cell-wall neutral polysaccharides
National audienc
Analysis of neutral and acid sugars in plant cell wall polysaccharides by gas-liquid chromatography
National audienc
Influence de la nature des fibres alimentaires sur la digestibilité des constituants de la ration chez le rat
National audienc
Dosage des polyholosides parietaux de substrats glucidiques et de leurs residus de digestion in vitro : comparaison de deux methodes analytiques
National audienc
Le retard de croissance intra-utérin (RCIU) altère-t-il la maturation de la barrière et la mise en place du microbiote colique au cours du développement postnatal ? (ces effets sont-ils encore perceptibles chez l'adulte ?)
NANTES-BU Sciences (441092104) / SudocSudocFranceF
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