828 research outputs found
Modified Gravity Makes Galaxies Brighter
We investigate the effect of modifed gravity with screening mechanisms, such
as the chameleon or symmetron models, upon the structure of main sequence
stars. We find that unscreened stars can be significantly more luminous and
ephemeral than their screened doppelgangers. By embedding these stars into
dwarf galaxies, which can be unscreened for values of the parameters not yet
ruled out observationally, we show that the cumulative effect of their
increased luminosity can enhance the total galactic luminosity. We estimate
this enhancement and find that it can be considerable given model parameters
that are still under experimental scrutiny. By looking for systematic offsets
between screened dwarf galaxies in clusters and unscreened galaxies in voids,
these effects could form the basis of an independent observational test that
can potentially lower the current experimental bounds on the model independent
parameters of these theories by and order of magnitude or more.Comment: 16 pages, six figure
The Chameleonic Contribution to the SZ Radial Profile of the Coma Cluster
We constrain the chameleonic Sunyaev--Zel'dovich (CSZ) effect in the Coma
cluster from measurements of the Coma radial profile presented in the WMAP
7-year results. The CSZ effect arises from the interaction of a scalar (or
pseudoscalar) particle with the cosmic microwave background in the magnetic
field of galaxy clusters. We combine this radial profile data with SZ
measurements towards the centre of the Coma cluster in different frequency
bands, to find Delta T_{SZ,RJ}(0)=-400+/-40 microKelvin and Delta T_{CSZ}^{204
GHz}(0)=-20+/-15 microKelvin (68% CL) for the thermal SZ and CSZ effects in the
cluster respectively. The central value leads to an estimate of the photon to
scalar (or pseudoscalar) coupling strength of g = (5.2 - 23.8) x 10^{-10}
GeV^{-1}, while the 95% confidence bound is estimated to be g < (8.7 - 39.4) x
10^{-10} GeV^{-1}.Comment: 13 pages, 3 figure
H2-M3–restricted CD8+ T cells are not required for MHC class Ib–restricted immunity against Listeria monocytogenes
Studies using major histocompatibility complex (MHC)-Ia–deficient mice have shown that MHC-Ib–restricted CD8+ T cells can clear infections caused by intracellular pathogens such as Listeria monocytogenes. M3-restricted CD8+ T cells, which recognize short hydrophobic N-formylated peptides, appear to comprise a substantial portion of the MHC-Ib–restricted T cell response in the mouse model of L. monocytogenes infection. In this study, we isolated formyltransferase (fmt) mutant strains of L. monocytogenes that lacked the ability to add formyl groups to nascent polypeptides. These fmt mutant Listeria strains did not produce antigens that could be recognized by M3-restricted T cells. We showed that immunization of MHC-Ia–deficient mice with fmt mutant Listeria resulted in stimulation of a protective memory response that cleared subsequent challenge with wild-type L. monocytogenes, despite the fact that M3-restricted CD8+ T cells did not proliferate in these mice. These data suggest that M3-restricted T cells are not required for protection against L. monocytogenes and underscore the importance of searching for new antigen-presenting molecules among the large MHC-Ib family of proteins
H2-M3-Restricted CD8\u3csup\u3e+\u3c/sup\u3e T Cells are not Required for MHC Class Ib-Restricted Immunity Against \u3cem\u3eListeria monocytogenes\u3c/em\u3e
Studies using major histocompatibility complex (MHC)-Ia–deficient mice have shown that MHC-Ib–restricted CD8+ T cells can clear infections caused by intracellular pathogens such as Listeria monocytogenes. M3-restricted CD8+ T cells, which recognize short hydrophobic N-formylated peptides, appear to comprise a substantial portion of the MHC-Ib–restricted T cell response in the mouse model of L. monocytogenes infection. In this study, we isolated formyltransferase (fmt) mutant strains of L. monocytogenes that lacked the ability to add formyl groups to nascent polypeptides. These fmt mutant Listeria strains did not produce antigens that could be recognized by M3-restricted T cells. We showed that immunization of MHC-Ia–deficient mice with fmt mutant Listeria resulted in stimulation of a protective memory response that cleared subsequent challenge with wild-type L. monocytogenes, despite the fact that M3-restricted CD8+ T cells did not proliferate in these mice. These data suggest that M3-restricted T cells are not required for protection against L. monocytogenes and underscore the importance of searching for new antigen-presenting molecules among the large MHC-Ib family of proteins
Molecular Gas in Candidate Double Barred Galaxies III. A Lack of Molecular Gas?
Most models of double-barred galaxies suggest that a molecular gas component
is crucial for maintaining long-lived nuclear bars. We have undertaken a CO
survey in an attempt to determine the gas content of these systems and to
locate double barred galaxies with strong CO emission that could be candidates
for high resolution mapping. We observed 10 galaxies in CO J=2-1 and J=3-2 and
did not detect any galaxies that had not already been detected in previous CO
surveys. We preferentially detect emission from galaxies containing some form
of nuclear activity. Simulations of these galaxies require that they contain 2%
to 10% gas by mass in order to maintain long-lived nuclear bars. The fluxes for
the galaxies for which we have detections suggest that the gas mass fraction is
in agreement with these models requirements. The lack of emission in the other
galaxies suggests that they contain as little as 7 x 10^6 solar masses of
molecular material which corresponds to < 0.1% gas by mass. This result
combined with the wide variety of CO distributions observed in double barred
galaxies suggests the need for models of double-barred galaxies that do not
require a large, well ordered molecular gas component.Comment: 17 pages (3 figures embedded on pg 17). To appear in the March 10
issue of the Astrophysical Journa
Livestock network analysis for rhodesiense human African trypanosomiasis control in Uganda
Background: Infected cattle sourced from districts with established foci for Trypanosoma brucei rhodesiense human African trypanosomiasis (rHAT) migrating to previously unaffected districts, have resulted in a significant expansion of the disease in Uganda. This study explores livestock movement data to describe cattle trade network topology and assess the effects of disease control interventions on the transmission of rHAT infectiousness.Methods: Network analysis was used to generate a cattle trade network with livestock data which was collected from cattle traders (n = 197) and validated using random graph methods. Additionally, the cattle trade network was combined with a susceptible, infected, recovered (SIR) compartmental model to simulate spread of rHAT (Ro 1.287), hence regarded as “slow” pathogen, and evaluate the effects of disease interventions.Results: The cattle trade network exhibited a low clustering coefficient (0.5) with most cattle markets being weakly connected and a few being highly connected. Also, analysis of the cattle movement data revealed a core group comprising of cattle markets from both eastern (rHAT endemic) and northwest regions (rHAT unaffected area). Presence of a core group may result in rHAT spread to unaffected districts and occurrence of super spreader cattle market or markets in case of an outbreak. The key cattle markets that may be targeted for routine rHAT surveillance and control included Namutumba, Soroti, and Molo, all of which were in southeast Uganda. Using effective trypanosomiasis such as integrated cattle injection with trypanocides and spraying can sufficiently slow the spread of rHAT in the network.Conclusion: Cattle trade network analysis indicated a pathway along which T. b. rhodesiense could spread northward from eastern Uganda. Targeted T. b. rhodesiense surveillance and control in eastern Uganda, through enhanced public–private partnerships, would serve to limit its spread
Molecular Gas in Candidate Double-Barred Galaxies II. Cooler, Less Dense Gas Associated with Stronger Central Concentrations
We have performed a multi-transition CO study of the centers of seven
double-barred galaxies that exhibit a variety of molecular gas morphologies to
determine if the molecular gas properties are correlated with the nuclear
morphology and star forming activity. Near infrared galaxy surveys have
revealed the existence of nuclear stellar bars in a large number of barred or
lenticular galaxies. High resolution CO maps of these galaxies exhibit a wide
range of morphologies. Recent simulations of double-barred galaxies suggest
that variations in the gas properties may allow it to respond differently to
similar gravitational potentials. We find that the 12CO J=3-2/J=2-1 line ratio
is lower in galaxies with centrally concentrated gas distributions and higher
in galaxies with CO emission dispersed around the galactic center in rings and
peaks. The 13CO/12CO J=2-1 line ratios are similar for all galaxies, which
indicates that the J=3-2/J=2-1 line ratio is tracing variations in gas
temperature and density, rather than variations in optical depth. There is
evidence that the galaxies which contain more centralized CO distributions are
comprised of molecular gas that is cooler and less dense. Observations suggest
that the star formation rates are higher in the galaxies containing the warmer,
denser, less centrally concentrated gas. It is possible that either the bar
dynamics are responsible for the variety of gas distributions and densities
(and hence the star formation rates) or that the star formation alone is
responsible for modifying the gas properties.Comment: 27 pages + 6 figures; to appear in the April 20, 2003 issue of Ap
Structural Basis of Chemokine Sequestration by a Tick Chemokine Binding Protein: The Crystal Structure of the Complex between Evasin-1 and CCL3
Chemokines are a subset of cytokines responsible for controlling the cellular migration of inflammatory cells through interaction with seven transmembrane G protein-coupled receptors. The blocking of a chemokine-receptor interaction results in a reduced inflammatory response, and represents a possible anti-inflammatory strategy, a strategy that is already employed by some virus and parasites. Anti-chemokine activity has been described in the extracts of tick salivary glands, and we have recently described the cloning and characterization of such chemokine binding proteins from the salivary glands, which we have named Evasins.We have solved the structure of Evasin-1, a very small and highly selective chemokine-binding protein, by x-ray crystallography and report that the structure is novel, with no obvious similarity to the previously described structures of viral chemokine binding proteins. Moreover it does not possess a known fold. We have also solved the structure of the complex of Evasin-1 and its high affinity ligand, CCL3. The complex is a 1:1 heterodimer in which the N-terminal region of CCL3 forms numerous contacts with Evasin-1, including prominent pi-pi interactions between residues Trp89 and Phe14 of the binding protein and Phe29 and Phe13 of the chemokine.However, these interactions do not appear to be crucial for the selectivity of the binding protein, since these residues are found in CCL5, which is not a ligand for Evasin-1. The selectivity of the interaction would appear to lie in the N-terminal residues of the chemokine, which form the "address" whereas the hydrophobic interactions in the rest of the complex would serve primarily to stabilize the complex. A thorough understanding of the binding mode of this small protein, and its other family members, could be very informative in the design of potent neutralizing molecules of pro-inflammatory mediators of the immune system, such as chemokines
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