11,335 research outputs found
Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes
Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing
The RD53 Collaboration's SystemVerilog-UVM Simulation Framework and its General Applicability to Design of Advanced Pixel Readout Chips
The foreseen Phase 2 pixel upgrades at the LHC have very challenging
requirements for the design of hybrid pixel readout chips. A versatile pixel
simulation platform is as an essential development tool for the design,
verification and optimization of both the system architecture and the pixel
chip building blocks (Intellectual Properties, IPs). This work is focused on
the implemented simulation and verification environment named VEPIX53, built
using the SystemVerilog language and the Universal Verification Methodology
(UVM) class library in the framework of the RD53 Collaboration. The environment
supports pixel chips at different levels of description: its reusable
components feature the generation of different classes of parameterized input
hits to the pixel matrix, monitoring of pixel chip inputs and outputs,
conformity checks between predicted and actual outputs and collection of
statistics on system performance. The environment has been tested performing a
study of shared architectures of the trigger latency buffering section of pixel
chips. A fully shared architecture and a distributed one have been described at
behavioral level and simulated; the resulting memory occupancy statistics and
hit loss rates have subsequently been compared.Comment: 15 pages, 10 figures (11 figure files), submitted to Journal of
Instrumentatio
Quasiperiodic Solutions of the Fibre Optics Coupled Nonlinear Schr{\"o}dinger Equations
We consider travelling periodical and quasiperiodical waves in single mode
fibres, with weak birefringence and under the action of cross-phase modulation.
The problem is reduced to the ``1:2:1" integrable case of the two-particle
quartic potential. A general approach for finding elliptic solutions is given.
New solutions which are associated with two-gap Treibich-Verdier potentials are
found. General quasiperiodic solutions are given in terms of two dimensional
theta functions with explicit expressions for frequencies in terms of theta
constants. The reduction of quasiperiodic solutions to elliptic functions is
discussed.Comment: 24 page
Stationary and moving breathers in a simplified model of curved alpha--helix proteins
The existence, stability and movability of breathers in a model for
alpha-helix proteins is studied. This model basically consists a chain of
dipole moments parallel to it. The existence of localized linear modes brings
about that the system has a characteristic frequency, which depends on the
curvature of the chain. Hard breathers are stable, while soft ones experiment
subharmonic instabilities that preserve, however the localization. Moving
breathers can travel across the bending point for small curvature and are
reflected when it is increased. No trapping of breathers takes place.Comment: 19 pages, 11 figure
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