Emotional distraction and bodily reaction: Modulation of autonomous responses by anodal tDCS to the prefrontal cortex

Prefrontal electric stimulation has been demonstrated to effectively modulate cognitive processing. Specifically, the amelioration of cognitive control over emotional distraction by transcranial direct current stimulation (tDCS) points towards targeted therapeutic applications in various psychiatric disorders. In addition to behavioral measures, autonomous nervous system (ANS) responses are fundamental bodily signatures of emotional information processing. However, interactions between the modulation of cognitive control by tDCS and ANS responses have received limited attention. We here report on ANS data gathered in healthy subjects that performed an emotional cognitive control task parallel to the modulation of left prefrontal cortical activity by 1mA anodal or sham tDCS. Skin conductance responses (SCRs) to negative and neutral pictures of human scenes were reduced by anodal as compared to sham tDCS. Individual SCR amplitude variations were associated with the amount of distraction. Moreover, the stimulation-driven performance- and SCR-modulations were related in form of a quadratic, inverse-U function. Thus, our results indicate that non-invasive brain stimulation (i.e., anodal tDCS) can modulate autonomous responses synchronous to behavioral improvements, but the range of possible concurrent improvements from prefrontal stimulation is limited. Interactions between cognitive, affective, neurophysiological, and vegetative responses to emotional content can shape brain stimulation effectiveness and require theory-driven integration in potential treatment protocols

‘Forget me (not)?’ – Remembering forget-items versus un-cued items in directed forgetting

Humans need to be able to selectively control their memories. Here, we investigate the underlying processes in item-method directed forgetting and compare the classic active memory cues in this paradigm with a passive instruction. Typically, individual items are presented and each is followed by either a forget- or remember-instruction. On a surprise test of all items, memory is then worse for to-be-forgotten items (TBF) compared to to-be-remembered items (TBR). This is thought to result from selective rehearsal of TBR, or from active inhibition of TBF, or from both. However, evidence suggests that if a forget instruction initiates active processing, paradoxical effects may also arise. To investigate the underlying mechanisms, four experiments were conducted where un-cued items (UI) were introduced and recognition performance was compared between TBR, TBF and UI stimuli. Accuracy was encouraged via a performance-dependent monetary bonus. Across all experiments, including perceptually fully matched variants, memory accuracy for TBF was reduced compared to TBR, but better than for UI. Moreover, participants used a more conservative response criterion when responding to TBF stimuli. Thus, ironically, the F cue results in active processing, but this does not have inhibitory effects that would impair recognition memory beyond a un-cued baseline condition. This casts doubts on inhibitory accounts of item-method directed forgetting and is also difficult to reconcile with pure selective rehearsal of TBR. While the F-cue does induce active processing, this does not result in particularly successful forgetting. The pattern seems most consistent with the notion of ironic processing