54 research outputs found
Prognostic factors for relapse in patients with clinical stage I testicular non-seminoma: A nationwide, population-based cohort study
BACKGROUND: Approximately 30% of patients with clinical stage I non-seminoma (CSI-NS) relapse. Current risk stratification is based on lymphovascular invasion (LVI) alone. The extent to which additional tumor characteristics can improve risk prediction remains unclear.OBJECTIVE: To determine the most important prognostic factors for relapse in CSI-NS patients.DESIGN, SETTING, AND PARTICIPANTS: Population-based cohort study including all patients with CSI-NS diagnosed in Denmark between 2013 and 2018 with follow-up until 2022. Patients were identified in the prospective Danish Testicular Cancer database. By linkage to the Danish National Pathology Registry, histological slides from the orchiectomy specimens were retrieved.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Histological slides were reviewed blinded to the clinical outcome. Clinical data were obtained from medical records. The association between prespecified potential prognostic factors and relapse was assessed using Cox regression analysis. Model performance was evaluated by discrimination (Harrell's C-index) and calibration.RESULTS: Of 453 patients included, 139 patients (30.6%) relapsed during a median follow-up of 6.3 years. Tumor invasion into the hilar soft tissue of the testicular hilum, tumor size, LVI and embryonal carcinoma were independent predictors of relapse. The estimated 5-year risk of relapse ranged from < 5% to > 85%, depending on the number of risk factors. After internal model validation, the model had an overall concordance statistic of 0.75. Model calibration was excellent.CONCLUSION AND RELEVANCE: The identified prognostic factors provide a much more accurate risk stratification than current clinical practice, potentially aiding clinical decision-making.</p
Crafting and Promoting International Crimes:A Controversy between Legal Professionals of Core Crimes and Anti-Corruption
The Import/Export of Police Models::Danish 19th Century Police Reform between Elites of Revolution and Reaction
Skabelsen af det moderne skandinaviske politi:Udkast til en komparativ historisk sociologi
Preaching, Practicing and Publishing International Criminal Justice:The Role of Academic Expertise in the Development of an International Field of Law
The Creation of an Ad Hoc Elite:And the Value of International Criminal Law Expertise on a Global Market
The Symbolic Economy of International Criminal Justice:Shaping the Discourse of a New Field of Law
International Prosecution and National Bureaucracy: The Contest to Define International Practices within the Danish Prosecution Service
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