Biological Posts: Natural Alternatives in Restoring Smile

Traumatic injuries leading to severely mutilated anterior teeth are common in dentistry. These injuries may leave a severe impact when they affect  ndodontically treated teeth as strength of such teeth is compromised. Proper functional and esthetic rehabilitation of such badly broken teeth is a challenge. Dealing with the patient’s mental suffering and their impatience to regain the natural smile back makes the treatment even more challenging. An effective treatment plan including a suitable and cost-effective choice of post is very much necessary in such conditions. Biological posts obtained through extracted teeth from another individual represent an economic option and alternative technique for the functional recovery of extensively damaged teeth. All-ceramic crowns further add to enhanced esthetics. This paper presents a case where biological posts with composite core build up followed by all-ceramic crown adaptation have been used with successful outcom

Effect of Fagonia arabica on thrombin induced release of t-PA and complex of PAI-1 tPA in cultured HUVE cells

Fagonia arabica (FA) possesses a thrombolytic property which has been earlier reported in our laboratory. Current study was undertaken to investigate the effect of aqueous extract of FA on thrombin-induced tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) release from cultured human umbilical vein endothelial cell line (HUVE) for studying its clot lytic activity. For this, establishment of cell line model has been done by isolating the cells from human umbilical cord. Cell toxicity was evaluated using XTT assay. Estimation of t-PA and PAI-1 t-PA complex were done using ELISA technique. Thrombin treatment induces the t-PA and PAI-1 release from HUVE cell line, and FA treatment was found to antagonize the thrombin induced t-PA and PAI-1 release. Our preliminary results suggest that FA may be used as an alternative to thrombolytic drug. However, study demands further experiments using animal model of thrombosis to establish the role of FA as a novel thrombolytic drug