203 research outputs found
Tracking Control of Vertical Pneumatic Artificial Muscle System Using PID
The advantages of pneumatic system such as compactness, high power to weight ratio, ease of maintenance, cleanliness and inherent safety led to the development of McKibben muscle and pneumatic artificial muscle (PAM). However, the air compressibility and the lack of damping ability of PAM bring dynamic delay to the pressure response and causes oscillatory motion to occur. It is not easy to realize the motion with high accuracy and high speed due to all the non-linear characteristics of pneumatic system. In this paper, we present a vertical PAM system with a simple PID controller to control the motion of the PAM. The experiment setup is explained and Ziegler Nichols tuning method is used in getting the approximation PID parameters. The effectiveness of the proposed control algorithm is demonstrated through experiments
On the determination of the Fermi surface in high-Tc superconductors by angle-resolved photoemission spectroscopy
We study the normal state electronic excitations probed by angle resolved
photoemission spectroscopy (ARPES) in Bi2201 and Bi2212. Our main goal is to
establish explicit criteria for determining the Fermi surface from ARPES data
on strongly interacting systems where sharply defined quasiparticles do not
exist and the dispersion is very weak in parts of the Brillouin zone.
Additional complications arise from strong matrix element variations within the
zone. We present detailed results as a function of incident photon energy, and
show simple experimental tests to distinguish between an intensity drop due to
matrix element effects and spectral weight loss due to a Fermi crossing. We
reiterate the use of polarization selection rules in disentangling the effect
of umklapps due to the BiO superlattice in Bi2212. We conclude that, despite
all the complications, the Fermi surface can be determined unambiguously: it is
a single large hole barrel centered about (pi,pi) in both materials.Comment: Expanded discussion of symmetrization method in Section 5, figures
remain the sam
Moyal Representation of the String Field Star Product in the Presence of a B-background
In this paper we show that in the presence of an anti-symmetric tensor
-background, Witten's star algebra for open string fields persists to
possess the structure of a direct product of commuting Moyal pairs. The
interplay between the noncommutativity due to three-string overlap and that due
to the -background is our main concern. In each pair of noncommutative
directions parallel to the -background, the Moyal pairs mix string modes in
the two directions and are labeled, in addition to a continuous parameter, by
{\it two} discrete values as well. However, the Moyal parameters are
-dependent only for discrete pairs. We have also demonstrated the large-
contraction of the star algebra, with one of the discrete Moyal pairs dropping
out while the other giving rise to the center-of-mass noncommutative function
algebra.Comment: minor notation chang
Noncommutativity from the string perspective: modification of gravity at a mm without mm sized extra dimensions
We explore how the IR pathologies of noncommutative field theory are resolved
when the theory is realized as open strings in background B-fields:
essentially, since the IR singularities are induced by UV/IR mixing, string
theory brings them under control in much the same way as it does the UV
singularities. We show that at intermediate scales (where the Seiberg-Witten
limit is a good approximation) the theory reproduces the noncommutative field
theory with all the (un)usual features such as UV/IR mixing, but that outside
this regime, in the deep infra-red, the theory flows continuously to the
commutative theory and normal Wilsonian behaviour is restored. The resulting
low energy physics resembles normal commutative physics, but with additional
suppressed Lorentz violating operators. We also show that the phenomenon of
UV/IR mixing occurs for the graviton as well, with the result that, in
configurations where Planck's constant receives a significant one-loop
correction (for example brane-induced gravity), the distance scale below which
gravity becomes non-Newtonian can be much greater than any compact dimensions.Comment: 30 pages. Slight revision: clarified some points and added a
referenc
Hawking Temperature in Taub-NUT (A)dS spaces via the Generalized Uncertainty Principle
Using the extended forms of the Heisenberg uncertainty principle from string
theory and the quantum gravity theory, we drived Hawking temperature of a
Taub-Nut-(A)dS black hole. In spite of their distinctive natures such as
asymptotically locally flat and breakdown of the area theorem of the horizon
for the black holes, we show that the corrections to Hawking temperature by the
generalized versions of the the Heisenberg uncertainty principle increases like
the Schwarzschild-(A)dS black hole and give the reason why the Taub-Nut-(A)dS
metric may have AdS/CFT dual picture.Comment: version published in General Relativity and Gravitatio
Tachyon Kinks on Unstable Dp-branes
In the context of tachyon effective theory coupled to Born-Infeld
electromagnetic fields, we obtain all possible singularity-free static flat
configurations of codimension one on unstable Dp-branes. Computed tension and
string charge density suggest that the obtained kinks are D(p-1) or
D(p-1)F1-branes.Comment: 22pages, LaTeX2e, 7figure
Cubic String Field Theory in pp-wave Background and Background Independent Moyal Structure
We study Witten open string field theory in the pp-wave background in the
tensionless limit, and construct the N-string vertex in the basis which
diagonalizes the string perturbative spectrum. We found that the Witten
*-product can be viewed as infinite copies of the Moyal product with the same
noncommutativity parameter . Moreover, we show that this Moyal
structure is universal in the sense that, written in the string bit basis,
Witten's *-product for any background can always be given in terms of the
above-mentioned Moyal structure. We identify some projective operators in this
algebra that we argue to correspond to D-branes of the theory.Comment: Latex, 23 pages, reference adde
On the independence of hydrogen production from methanogenic suppressor in olive mill wastewater
Anaerobic degradation of olive mill wastewater (OMW) at concentrations ranging from 2 to 100 g/L of chemical oxygen demand (COD) was assessed in batch assays. Methane was the main final product obtained for the lower concentrations tested. For 25 g COD/L, H2 was temporarily produced, albeit H2 depletion occurred, likely due to homoacetogenesis, since acetate was formed concomitantly. Hydrogen was produced and accumulated permanently in the assays containing 50 g COD/L of OMW. Methanogenesis and homoacetogenesis were naturally inhibited, suggesting that hydrogen recovery from OMW can be performed without the addition of methanogenic suppressors such as 2-bromoethanosulfonate. This fact opens new perspectives for the utilization of high OMW concentrations in a two-stage valorisation process combining biohydrogen and biomethane production.The authors thank the FCT Strategic Project PEst-OE/EQB/LA0023/2013, the FCT Project RECI/BBB-EBI/0179/2012, the Project "BioEnv - Biotechnology and Bioengineering for a sustainable world", REF. NORTE-07-0124-FEDER-000048, co-funded by the Programa Operacional Regional do Norte (ON.2 - O Novo Norte), QREN, FEDER. Also through the project PTDC/ENR/69755/2006 and grants given to Marta Goncalves SFRH/BD/40746/2007, Jose Carlos Costa SFRH/BDP/48962/2008 and Angela A Abreu SFRH/BPD/82000/2011
Novel Druggable Hot Spots in Avian Influenza Neuraminidase H5N1 Revealed by Computational Solvent Mapping of a Reduced and Representative Receptor Ensemble
The influenza virus subtype H5N1 has raised concerns of a possible human pandemic threat because of its high virulence and mutation rate. Although several approved anti-influenza drugs effectively target the neuraminidase, some strains have already acquired resistance to the currently available anti-influenza drugs. In this study, we present the synergistic application of extended explicit solvent molecular dynamics (MD) and computational solvent mapping (CS-Map) to identify putative ‘hot spots’ within flexible binding regions of N1 neuraminidase. Using representative conformations of the N1 binding region extracted from a clustering analysis of four concatenated 40-ns MD simulations, CS-Map was utilized to assess the ability of small, solvent-sized molecules to bind within close proximity to the sialic acid binding region. Mapping analyses of the dominant MD conformations reveal the presence of additional hot spot regions in the 150- and 430-loop regions. Our hot spot analysis provides further support for the feasibility of developing high-affinity inhibitors capable of binding these regions, which appear to be unique to the N1 strain
Integrated multi-omics for rapid rare disease diagnosis on a national scale
Published online: 8 June 2023Critically ill infants and children with rare diseases need equitable access to rapid and accurate diagnosis to direct clinical management. Over 2 years, the Acute Care Genomics program provided whole-genome sequencing to 290 families whose critically ill infants and children were admitted to hospitals throughout Australia with suspected genetic conditions. The average time to result was 2.9 d and diagnostic yield was 47%. We performed additional bioinformatic analyses and transcriptome sequencing in all patients who remained undiagnosed. Long-read sequencing and functional assays, ranging from clinically accredited enzyme analysis to bespoke quantitative proteomics, were deployed in selected cases. This resulted in an additional 19 diagnoses and an overall diagnostic yield of 54%. Diagnostic variants ranged from structural chromosomal abnormalities through to an intronic retrotransposon, disrupting splicing. Critical care management changed in 120 diagnosed patients (77%). This included major impacts, such as informing precision treatments, surgical and transplant decisions and palliation, in 94 patients (60%). Our results provide preliminary evidence of the clinical utility of integrating multi-omic approaches into mainstream diagnostic practice to fully realize the potential of rare disease genomic testing in a timely manner.Sebastian Lunke ... Peer Arts ... Christopher P. Barnett ..., Chirag V. Patel ... Hamish S. Scott ... Karin S. Kassahn ... et al
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