7 research outputs found
HAEMATOLOGICAL PARAMETERS IN H UMAN I MMUNODEFICIENCY V IRUS POSITIVE INDIVIDUALS ON DIFFERENT HAART REGIMEN .
Highly active antiretroviral viral therapy (HAART), a combination of
three antiretrovirals from at least two drug classes for optimization of
hindrance to HIV replication has g
reatly increased life expectance.
There however, exist numerous of these combinations and thus the
questions of which is the best HAART combination with respect to the
individualâs haematological status. To investigate this, blood samples
were collected fr
om 231 retropositive subjects on six different HAART
combinations at least six months after HAART commencement,
assayed for CD4 and some haematological parameters using cyflow
and sysmex(KX
-
21) autoanalysier. Baseline data was accessed from
the LAMIS data
base. The difference between baseline and values after
HAART was taken and statistically compared. HAART evaluated
includes, Combivir(NVP), Combivir(EFV), Truvada(NVP), Truvada(EFV), Lanten(NVP)
and Lanten(EFV). The difference in the parameters assayed a
re: CD4(cellmm
-
3
): 154, 205,
172, 206, 262, and 230(P=0.478). Haemoglobin(gdl
-
1):
-
0.78,
-
0.73, 2.35, 1.48, 1.11 and
1.27(P=0.010). PCV(%):
-
2.34,
-
2.19, 7.65, 7.02, 3.36 and 3.12(P=0.0001). WBC(10
3
ÎŒl
-
1
):
-
1.19,
-
1.02,
-
0.37, 0.06, 1.14 and
-
0.63(P=0.001)
. Neutrophil(%):
-
1.51,
-
1.83, 3.87, 2.07,
2.71, 2.71 and 1.97(P=0.868). Lymphocyte(%):
-
4.26,
-
2.87,
-
1.45,
-
0.19, 2.36 and
3.40(P=0.790). Eosinophil(%):
-
0.41, 0.14,
-
2.65, 0.14,
-
0.46 and 0.12(P=0.094). Platelet(10
3
ÎŒl
-
1
):
-
49,
-
39,
-
53,
-
53,
-
47 and
-
35
(P=0.931). The Zidovudine based
combinations showed anaemic tendencies; Nevirapen based combinations showed
Eosinopenic tendencies. All HAART used induced good immunologic responses along with
thrombocytopenic tendencies. The data generated was however ins
ufficient to discriminate
one combination as being better than the other, rather it was observed that the haematological
profile of clients must be well considered when selecting HAAR