4 research outputs found
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Evaluation of Surface Roughness of Microhybrid and Nanofilled Composites after pH-Cycling and Simulated Toothbrushing
- Author
- Attin T Buchalla W, Hellwig E.
- Beun S Glorieux T, Devaux J, Vreven J, Leloup G.
- Charig A Winston A, Flickinger M.
- Choi MS Lee YK, Lim BS, Rhee SH, Yang HC.
- Heintze SD.
- Ikejima I Nomoto R, McCabe JF.
- Mitra SB Wu D, Holmes BN.
- Mondelli RF Wang L, Garcia FC, Prakki A, Mondelli J, Franco EB, Ishikiriama A.
- Ortengren U Andersson F, Elgh U, Terselius B, Karlsson S.
- Prakki A Cilli R, Mondelli RF, Kalachandra S, Pereira JC.
- Sarrett DC Coletti DP, Peluso AR.
- Senawongse P Pongprueksa P.
- Serra MC Cury JA.
- Teixeira EC Thompson JL, Piascik JR, Thompson JY.
- Terry DA.
- Turssi CP de Magalhães CS, Serra MC, Rodrigues Júnior AL.
- Turssi CP Ferracane JL, Ferracane LL.
- Turssi CP Ferracane JL, Vogel K.
- Turssi CP Hara AT, de Magalhães CS, Serra MC, Rodrigues AL Jr.
- Wang L Garcia FC, Amarante de Araújo P, Franco EB, Mondelli RF.
- Watari F.
- Yap AU Chew CL, Ong LF, Teoh SH.
- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study
Panax ginseng
- Author
- A Karadeniz
- A Karadeniz
- A Takeda
- A Takeda
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- AC Cabral de Oliveira
- AC Cabral de Oliveira
- AH Bitties
- AH Chu
- AM Abd El-Aty
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- B He
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- BH Han
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- BM Kwon
- BM Kwon
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- BS Hong
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- C Hallstrom
- C Hiyama
- C Kim
- C Konno
- C Li
- C Li
- C Wakabayashi
- CC Cheng
- CC Ruan
- CF Su
- CH Choi
- CH Jung
- CH Jung
- CH Jung
- CJ Shao
- CJ Shao
- CJ Shao
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- CJ Tian
- CJ Xu
- CM Teng
- CN Tong
- CPF Wong
- CR Hwang
- CS Sang
- CS Yuan
- CX Qiao
- CY Weng
- CZ Zhang
- D Chen
- D Lu
- D Tsang
- D Washida
- DB Wan
- DC Kim
- DC Lee
- DG Popovich
- DG Popovich
- DH Kim
- DH Kim
- DH Lee
- DH Luo
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- DO Kennedy
- DQ Dou
- DS Kim
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- E Hasegawa
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- E Rivera
- E Vera-Barrios
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- EA Bae
- EA Bae
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- EA Bae
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- EH Kim
- EH Park
- EJ Cho
- EJ Cho
- EJ Kim
- EJ Ko
- EJ Lee
- EJ Park
- EK Park
- EK Park
- EK Park
- EM Greenspan
- EV Avakian
- EV Avakian
- EY Lee
- F Herrmann
- F Qiu
- F Qiu
- F Qiu
- F Su
- G Hiai
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- GB Elyakov
- GB Elyakov
- GI Scott
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- GS Oh
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- JM Kampen Van
- JM Kampen Van
- JM Zhao
- JP Cai
- JP Hou
- JS Lee
- JS Mogil
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- JS Shin
- JS Shin
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- JT Hwang
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- JY Kim
- JY Lee
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- JY Yu
- K Gommori
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- K Hirakura
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- K Kawaguchi
- K Kim
- K Norajit
- K Sakakibara
- K Samukawa
- K Samukawa
- K Sato
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- K Takagi
- K Takagi
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- K Takiura
- K Takiura
- K Yamasaki
- KH Han
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- KK Li
- KM Joo
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- L Dey
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- L Larina
- L Li
- L Liu
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- M Pannacci
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- M Ushiyama
- M Ushiyama
- M Yamada
- M Yamamoto
- M Yamamoto
- M Yeo
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- T Ramesh
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- T Tode
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- T Yokozawa
- T Yokozawa
- T Yokozawa
- T Yokozawa
- T Yokozawa
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- T Yokozawa
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- T Yokozawa
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- U Banerjee
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- V Karpagam
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- XQ Gao
- XY Su
- Y Asada
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- Y Gao
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- Y Matsuura
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- YK Kim
- YK Lee
- YL Liang
- YL Ming
- YM Han
- YM Tsutsumi
- YM Zhong
- YN Han
- YN Lee
- YN Lee
- YN Zheng
- YP Yun
- YQ Qiu
- YR Jin
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- YS Keum
- YS Keum
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- YS Kim
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- YW Kim
- YX Xu
- YY Fan
- YZ Xiang
- Z Dabrowski
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Color Stability and Surface Roughness of Composite submitted to Different Types and Periods of Finishing/Polishing: Physical Properties of Composites
- Author
- Atabek D Sillelioglu H, Olmez A.
- Bagheri R Burrow MF, Tyas M.
- Berger SB Palialol AR, Cavalli V, Giannini M.
- Bollen CM Lambrechts P, Quirynen M.
- Choi MS Lee YK, Lim BS, Rhee SH, Yang HC.
- Chung KH.
- Da Silva FMJ Da Rocha MD, Travassos CA, Fernandes BVV Jr, Rodrigues RJ.
- Deligeorgi V Mjör IA, Wilson NH.
- Ferracane JL.
- Gaengler P Hoyer I, Montag R, Gaebler P.
- Ghinea R Ugarte-Alvan L, Yebra A, Pecho OE, Paravina RD, Perez Mdel M.
- Giacomelli L Derchi G, Frustaci A, Bruno O, Covani U, Barone A, De Santis D, Chiappelli F.
- Guler AU Kurt S, Kulunk T.
- Heintze SD Forjanic M, Rousson V.
- Hosoya Y Shiraishi T, Puppin-Rontani RM, Powers JM.
- Jefferies SR Barkmeier WW, Gwinnett AJ.
- Kim KH. Ong JL. Okuno O.
- Korkmaz Y Ozel E, Attar N, Aksoy G.
- Marghalani HY.
- Micali B. Basting RT.
- Mjör IA Moorhead JE, Dahl JE.
- Pires-de-Souza FCP C Casemiro LA, Garcia Lda F, Cruvinel DR.
- Pires-de-Souza FCP Garcia Lda F, Hamida HM, Casemiro LA.
- Reis AF Giannini M, Lovadino JR, Ambrosano GM.
- Rodrigues SA Jr Scherrer SS, Ferracane JL, Della Bona A.
- Ruttermann S Wandrey C, Raab WHM, Janda R.
- Ruyter IE Nilner K, Moller B.
- Santerre JP Shajii L, Leung BW.
- Schulze KA Marshall SJ, Gansky SA, Marshall GW.
- Shimomura H.
- Shintani H Satou N, Yukihiro A, Satou J, Yamane I, Kouzai T, Andou T, Kai M, Hayashihara H, Inoue T.
- Soares LE Cesar IC, Santos CG, De Cardoso AL, Liporoni PC, Munin E, Martin AA.
- Soares LES Liporoni PCS, Martin AA.
- Zanin FR Garcia Lda F, Casemiro LA, Pires-de-souza Fde C.
- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study